Niclosamide (olamine)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT18 keratin 18, type I 0.155227
AKAP12 A kinase (PRKA) anchor protein 12 0.112736
RPS6 ribosomal protein S6 0.0816631
FTH1 ferritin, heavy polypeptide 1 0.0670164
CDH13 cadherin 13 0.061269
TPT1 tumor protein, translationally-controlled 1 0.0605811
RPL35A ribosomal protein L35a 0.0590135
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0562226
PLEC plectin 0.0550617
NAV2 neuron navigator 2 0.0458307
CCND1 cyclin D1 0.0402547
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0379291
ANO1 anoctamin 1, calcium activated chloride channel 0.0364341
ITGB4 integrin, beta 4 0.0357645
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0287185
RPL11 ribosomal protein L11 0.0282321
RPL13A ribosomal protein L13a 0.0280396
H1-0 H1.0 linker histone 0.0280116
SDK1 sidekick cell adhesion molecule 1 0.027538
NDRG1 N-myc downstream regulated 1 0.0271341
RPL37A ribosomal protein L37a 0.0271122
MRPS6 mitochondrial ribosomal protein S6 0.0257932
EGR1 early growth response 1 0.0252052
IGFBP3 insulin-like growth factor binding protein 3 0.0250405
NTSR1 neurotensin receptor 1 (high affinity) 0.0244278
RPS8 ribosomal protein S8 0.0242623
PTMA prothymosin, alpha 0.0240705
KRT19 keratin 19, type I 0.0236242
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0233562
RPS19 ribosomal protein S19 0.0231464
TMSB4X thymosin beta 4, X-linked 0.0227807
PDGFA platelet-derived growth factor alpha polypeptide 0.022408
MYOF myoferlin 0.0222404
RPL12 ribosomal protein L12 0.0215691
BACE2 beta-site APP-cleaving enzyme 2 0.021475
TPM4 tropomyosin 4 0.0210263
RPL19 ribosomal protein L19 0.0207325
RPL21 ribosomal protein L21 0.0202145
RPLP0 ribosomal protein, large, P0 0.020191
ADGRL2 adhesion G protein-coupled receptor L2 0.0201774
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0198734
MAML2 mastermind-like 2 (Drosophila) 0.0193
RPS2 ribosomal protein S2 0.0192955
MT2A metallothionein 2A 0.0191448
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.0189362
RPS12 ribosomal protein S12 0.0180395
FOSL1 FOS-like antigen 1 0.0179613
IER3 immediate early response 3 0.0175661
LOC102724023 ES1 protein homolog, mitochondrial 0.0175104
NPAS2 neuronal PAS domain protein 2 0.0172993
SKAP1 src kinase associated phosphoprotein 1 0.0172328
RPL34 ribosomal protein L34 0.0172001
KRT8 keratin 8, type II 0.0169403
SQSTM1 sequestosome 1 0.0168544
RPL35 ribosomal protein L35 0.0167549
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0167234
CDK6 cyclin-dependent kinase 6 0.0166697
STC2 stanniocalcin 2 0.0163955
HMGA1 high mobility group AT-hook 1 0.0163788
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0158825
ANXA2 annexin A2 0.0157242
FLNB filamin B, beta 0.0156506
ITGA6 integrin, alpha 6 0.0155616
RPL38 ribosomal protein L38 0.0154983
FTL ferritin, light polypeptide 0.015286
RPS13 ribosomal protein S13 0.0150698
CUX1 cut-like homeobox 1 0.014494
RPS29 ribosomal protein S29 0.0143958
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0142455
RPS14 ribosomal protein S14 0.014168
RPLP1 ribosomal protein, large, P1 0.014106
DDIT4 DNA-damage-inducible transcript 4 0.0140779
RPS16 ribosomal protein S16 0.0140769
ANXA3 annexin A3 0.0137943
ESYT2 extended synaptotagmin-like protein 2 0.0137532
RPS10 ribosomal protein S10 0.013632
ERRFI1 ERBB receptor feedback inhibitor 1 0.0136269
AIG1 androgen-induced 1 0.0134368
ACTG1 actin gamma 1 0.013075
RPLP2 ribosomal protein, large, P2 0.0130625
IGF2 insulin-like growth factor 2 0.0122302
S100A6 S100 calcium binding protein A6 0.0121947
RSL1D1 ribosomal L1 domain containing 1 0.0121548
S100A4 S100 calcium binding protein A4 0.0120659
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0120462
RPS11 ribosomal protein S11 0.0119546
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0118872
LGALS1 lectin, galactoside-binding, soluble, 1 0.0115365
NACA nascent polypeptide-associated complex alpha subunit 0.0113539
PFN1 profilin 1 0.0112366
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0111971
RPL30 ribosomal protein L30 0.011189
BZW1 basic leucine zipper and W2 domains 1 0.0111366
RPL27 ribosomal protein L27 0.0110986
GTF2IRD1 GTF2I repeat domain containing 1 0.011094
PPARG peroxisome proliferator-activated receptor gamma 0.0109522
ZBTB20 zinc finger and BTB domain containing 20 0.0108658
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0108161
RPS17 ribosomal protein S17 0.0106604
NOP56 NOP56 ribonucleoprotein 0.0106105

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.126984
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.118402
PCBP2 poly(rC) binding protein 2 -0.111117
RPS27A ribosomal protein S27a -0.101667
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.099272
ENO1 enolase 1, (alpha) -0.0915605
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.076918
AHNAK AHNAK nucleoprotein -0.0731752
EEF2 eukaryotic translation elongation factor 2 -0.0537583
VMP1 vacuole membrane protein 1 -0.0537564
ACTN4 actinin, alpha 4 -0.0491253
LMO7 LIM domain 7 -0.0489887
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0488913
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0486693
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0482619
SFPQ splicing factor proline/glutamine-rich -0.0477247
SYT1 synaptotagmin I -0.0466339
DIAPH3 diaphanous-related formin 3 -0.0450163
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0448827
RPL23 ribosomal protein L23 -0.0445053
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0439541
TNS3 tensin 3 -0.0436103
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0433592
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0430992
CEMIP2 cell migration inducing hyaluronidase 2 -0.0429609
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0428341
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0427827
OXR1 oxidation resistance 1 -0.0425396
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0398172
ZNF638 zinc finger protein 638 -0.039168
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0390334
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0381773
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.037986
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0376437
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.037595
PKM pyruvate kinase, muscle -0.0367447
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0366921
LDHA lactate dehydrogenase A -0.0364985
USP9X ubiquitin specific peptidase 9, X-linked -0.0363918
PGK1 phosphoglycerate kinase 1 -0.0363051
VGLL4 vestigial-like family member 4 -0.0356577
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0351669
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0349612
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0348878
YAP1 Yes-associated protein 1 -0.0347606
JUN jun proto-oncogene -0.0346767
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0330716
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0324892
PROX1 prospero homeobox 1 -0.0323838
NONO non-POU domain containing, octamer-binding -0.0320713
OGA O-GlcNAcase -0.0317236
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0316882
PCLO piccolo presynaptic cytomatrix protein -0.0316467
SMC4 structural maintenance of chromosomes 4 -0.0316379
ETNK1 ethanolamine kinase 1 -0.0314526
CANX calnexin -0.0308656
AOPEP aminopeptidase O (putative) -0.0308547
TXNIP thioredoxin interacting protein -0.0308085
ATAD2 ATPase family, AAA domain containing 2 -0.0307845
RNF43 ring finger protein 43 -0.0306161
NIPBL Nipped-B homolog (Drosophila) -0.0302517
ZFAND3 zinc finger, AN1-type domain 3 -0.0301823
SERINC3 serine incorporator 3 -0.0300744
EIF4A2 eukaryotic translation initiation factor 4A2 -0.029918
PCM1 pericentriolar material 1 -0.0298221
MATR3 matrin 3 -0.0294943
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0293678
XPO1 exportin 1 -0.0291721
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0283144
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0282943
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0282231
GLG1 golgi glycoprotein 1 -0.0281466
RBM39 RNA binding motif protein 39 -0.0280991
RAD21 RAD21 homolog (S. pombe) -0.0278463
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0275723
KIZ kizuna centrosomal protein -0.0269723
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0268792
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0268591
LRP6 low density lipoprotein receptor-related protein 6 -0.0265669
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0264899
USP34 ubiquitin specific peptidase 34 -0.0261942
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0261811
MYH9 myosin, heavy chain 9, non-muscle -0.025849
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0258165
FOXP1 forkhead box P1 -0.0253944
RBM33 RNA binding motif protein 33 -0.0253914
NKD1 naked cuticle homolog 1 (Drosophila) -0.025351
ANO6 anoctamin 6 -0.0252884
IPO7 importin 7 -0.0250661
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0249866
CD46 CD46 molecule, complement regulatory protein -0.0249048
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0246718
ZNF292 zinc finger protein 292 -0.0245614
DLG1 discs, large homolog 1 (Drosophila) -0.0243599
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0243503
TNPO1 transportin 1 -0.0243107
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0241642
ARL15 ADP-ribosylation factor-like 15 -0.0241042
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0240792
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0240748