Nicotine pharmacodynamics pathway Gene Set

Dataset PANTHER Pathways
Category structural or functional annotations
Type pathway
Description The pathway of nicotine-target interaction and of the biochemical or physiological responses to them. Nicotine is an agonist of the nicotinic acetylcholine receptors and exerts stimulatory roles. It is also responsible for tobacco dependence. Prolonged exposure and high levels of nicotine can have toxic effects. Genetic variations can cause differences in the response of the organism to the drug. (Pathway Ontology, PW_0001450)
External Link http://www.pantherdb.org/pathway/pathDetail.do?clsAccession=P06587
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Genes

30 proteins participating in the Nicotine pharmacodynamics pathway pathway from the PANTHER Pathways dataset.

Symbol Name
ADCY2 adenylate cyclase 2 (brain)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CDK5 cyclin-dependent kinase 5
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLIC6 chloride intracellular channel 6
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
EPB41 erythrocyte membrane protein band 4.1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FLNA filamin A, alpha
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRB2 growth factor receptor-bound protein 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNK9 potassium channel, two pore domain subfamily K, member 9
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
TH tyrosine hydroxylase