Nicotine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. It has been isolated from Nicotiana tabacum. (Chemical Entities of Biological Interest Ontology, CHEBI_18723)
External Link http://ctdbase.org/detail.go?type=chem&acc=D009538
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Genes

239 genes/proteins interacting with the chemical Nicotine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACHE acetylcholinesterase (Yt blood group)
ACSL6 acyl-CoA synthetase long-chain family member 6
ADM2 adrenomedullin 2
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AGTR2 angiotensin II receptor, type 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAD aminolevulinate dehydratase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
APP amyloid beta (A4) precursor protein
ARRB1 arrestin, beta 1
ATF6 activating transcription factor 6
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AVP arginine vasopressin
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BIRC2 baculoviral IAP repeat containing 2
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CALB1 calbindin 1, 28kDa
CALCRL calcitonin receptor-like
CARTPT CART prepropeptide
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCND2 cyclin D2
CCNE1 cyclin E1
CCS copper chaperone for superoxide dismutase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAT choline O-acetyltransferase
CHEK2 checkpoint kinase 2
CHGB chromogranin B
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CNR1 cannabinoid receptor 1 (brain)
CORT cortistatin
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DNM1L dynamin 1-like
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EDNRB endothelin receptor type B
EEF2 eukaryotic translation elongation factor 2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FGF2 fibroblast growth factor 2 (basic)
FMO3 flavin containing monooxygenase 3
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
FSHB follicle stimulating hormone, beta polypeptide
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GAP43 growth associated protein 43
GATA2 GATA binding protein 2
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GPX1 glutathione peroxidase 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSR glutathione reductase
GSTA4 glutathione S-transferase alpha 4
H2AFX H2A histone family, member X
HAVCR1 hepatitis A virus cellular receptor 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HINT1 histidine triad nucleotide binding protein 1
HMOX1 heme oxygenase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL6 interleukin 6
IL7 interleukin 7
INSR insulin receptor
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
IVL involucrin
JUN jun proto-oncogene
KNG1 kininogen 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LEP leptin
LHB luteinizing hormone beta polypeptide
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MT3 metallothionein 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NANOG Nanog homeobox
NEFM neurofilament, medium polypeptide
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
NOTCH4 notch 4
NOX4 NADPH oxidase 4
NPY neuropeptide Y
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A1 nuclear receptor subfamily 5, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPRD1 opioid receptor, delta 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PENK proenkephalin
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLCG1 phospholipase C, gamma 1
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PNOC prepronociceptin
POMC proopiomelanocortin
PON1 paraoxonase 1
POU5F1 POU class 5 homeobox 1
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCZ protein kinase C, zeta
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RB1 retinoblastoma 1
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPTOR regulatory associated protein of MTOR, complex 1
RYR2 ryanodine receptor 2 (cardiac)
SIRT1 sirtuin 1
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNAI1 snail family zinc finger 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAR steroidogenic acute regulatory protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBXA2R thromboxane A2 receptor
TFDP1 transcription factor Dp-1
TH tyrosine hydroxylase
TJP1 tight junction protein 1
TNF tumor necrosis factor
TP53 tumor protein p53
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPO translocator protein (18kDa)
UBA2 ubiquitin-like modifier activating enzyme 2
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
VEGFA vascular endothelial growth factor A
VIM vimentin
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZFP36 ZFP36 ring finger protein