| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A dihydropyridine that has formula C17H18N2O6. (Chemical Entities of Biological Interest Ontology, CHEBI_7565) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4485 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Nifedipine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BTBD3 | BTB (POZ) domain containing 3 | 1.82 |
| RAB40C | RAB40C, member RAS oncogene family | 1.55 |
| ZBED8L | ZBED8 like | 1.17 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 1.0 |
| GGT1 | gamma-glutamyltransferase 1 | 0.95 |
| F8 | coagulation factor VIII, procoagulant component | 0.93 |
| TMEM168 | transmembrane protein 168 | 0.92 |
| HGFAC | HGF activator | 0.91 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.88 |
| CD58 | CD58 molecule | 0.85 |
| SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | 0.81 |
| FN1 | fibronectin 1 | 0.77 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.76 |
| NEDD8 | neural precursor cell expressed, developmentally down-regulated 8 | 0.72 |
| APOB | apolipoprotein B | 0.68 |
| ARFGAP2 | ADP-ribosylation factor GTPase activating protein 2 | 0.65 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.6 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.59 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.58 |
| ZBED8 | zinc finger, BED-type containing 8 | 0.55 |
| DOCK11 | dedicator of cytokinesis 11 | 0.51 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.48 |
| ZNF76 | zinc finger protein 76 | 0.47 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 0.47 |
| NAV3 | neuron navigator 3 | 0.45 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.44 |
| H3C1 | H3 clustered histone 1 | 0.42 |
| ANKRD13B | ankyrin repeat domain 13B | 0.4 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | 0.4 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.38 |
| MZT2B | mitotic spindle organizing protein 2B | 0.37 |
| EIF4E | eukaryotic translation initiation factor 4E | 0.37 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 0.37 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.37 |
| BFAR | bifunctional apoptosis regulator | 0.37 |
| CDCA7 | cell division cycle associated 7 | 0.37 |
| AEN | apoptosis enhancing nuclease | 0.36 |
| ATXN2 | ataxin 2 | 0.36 |
| MNX1 | motor neuron and pancreas homeobox 1 | 0.35 |
| USP53 | ubiquitin specific peptidase 53 | 0.35 |
| C12ORF57 | chromosome 12 open reading frame 57 | 0.34 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 0.34 |
| BBS1 | Bardet-Biedl syndrome 1 | 0.34 |
| SPICE1 | spindle and centriole associated protein 1 | 0.33 |
| VMP1 | vacuole membrane protein 1 | 0.33 |
| C4ORF33 | chromosome 4 open reading frame 33 | 0.32 |
| CAPN6 | calpain 6 | 0.32 |
| TBC1D14 | TBC1 domain family, member 14 | 0.32 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.31 |
| MARVELD3 | MARVEL domain containing 3 | 0.31 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.31 |
| RNFT2 | ring finger protein, transmembrane 2 | 0.31 |
| KPTN | kaptin (actin binding protein) | 0.3 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.3 |
| FKBP7 | FK506 binding protein 7 | 0.3 |
| TASP1 | taspase, threonine aspartase, 1 | 0.3 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | 0.29 |
| ADCK5 | aarF domain containing kinase 5 | 0.29 |
| MATR3 | matrin 3 | 0.29 |
| KHK | ketohexokinase (fructokinase) | 0.29 |
| ZNF791 | zinc finger protein 791 | 0.29 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.28 |
| RMDN2 | regulator of microtubule dynamics 2 | 0.28 |
| NRP1 | neuropilin 1 | 0.28 |
| FER1L5 | fer-1-like family member 5 | 0.28 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | 0.27 |
| TSPYL2 | TSPY-like 2 | 0.27 |
| VAC14 | Vac14 homolog (S. cerevisiae) | 0.27 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.27 |
| ZNF768 | zinc finger protein 768 | 0.27 |
| NAT14 | N-acetyltransferase 14 (GCN5-related, putative) | 0.27 |
| ETNK2 | ethanolamine kinase 2 | 0.27 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.27 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | 0.27 |
| SP100 | SP100 nuclear antigen | 0.26 |
| TCTEX1D2 | Tctex1 domain containing 2 | 0.26 |
| FBXO31 | F-box protein 31 | 0.25 |
| GPATCH2L | G patch domain containing 2-like | 0.25 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.25 |
| HBA1 | hemoglobin, alpha 1 | 0.25 |
| MAGEA6 | melanoma antigen family A6 | 0.25 |
| FAM53B | family with sequence similarity 53, member B | 0.24 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.24 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | 0.24 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.24 |
| CCDC66 | coiled-coil domain containing 66 | 0.24 |
| GCFC2 | GC-rich sequence DNA-binding factor 2 | 0.24 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | 0.24 |
| LAMC2 | laminin, gamma 2 | 0.24 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.24 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | 0.24 |
| ZNF587 | zinc finger protein 587 | 0.24 |
| CFAP36 | cilia and flagella associated protein 36 | 0.23 |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | 0.23 |
| MYO19 | myosin XIX | 0.23 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 0.23 |
| ZNF91 | zinc finger protein 91 | 0.23 |
| GSN | gelsolin | 0.23 |
| RPS15 | ribosomal protein S15 | 0.23 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAH5 | dynein, axonemal, heavy chain 5 | -3.27 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -2.26 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -2.07 |
| TDRD9 | tudor domain containing 9 | -1.83 |
| GALNT13 | polypeptide N-acetylgalactosaminyltransferase 13 | -1.65 |
| CCDC73 | coiled-coil domain containing 73 | -1.62 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | -1.43 |
| PIP | prolactin-induced protein | -1.31 |
| KSR2 | kinase suppressor of ras 2 | -1.24 |
| TEN1 | TEN1 CST complex subunit | -1.1 |
| PER2 | period circadian clock 2 | -1.05 |
| PRG4 | proteoglycan 4 | -0.79 |
| OPHN1 | oligophrenin 1 | -0.72 |
| SELENOW | selenoprotein W | -0.69 |
| DES | desmin | -0.66 |
| ASPHD2 | aspartate beta-hydroxylase domain containing 2 | -0.64 |
| CCDC18 | coiled-coil domain containing 18 | -0.64 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.64 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.62 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.61 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.59 |
| TSPYL4 | TSPY-like 4 | -0.59 |
| SUSD1 | sushi domain containing 1 | -0.58 |
| TET3 | tet methylcytosine dioxygenase 3 | -0.57 |
| GK5 | glycerol kinase 5 (putative) | -0.57 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -0.57 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.56 |
| NALCN | sodium leak channel, non selective | -0.54 |
| HEXD | hexosaminidase D | -0.54 |
| TMEM231 | transmembrane protein 231 | -0.54 |
| MYORG | myogenesis regulating glycosidase (putative) | -0.54 |
| MLXIPL | MLX interacting protein-like | -0.53 |
| VGF | VGF nerve growth factor inducible | -0.48 |
| PSEN2 | presenilin 2 | -0.47 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | -0.46 |
| DISP2 | dispatched homolog 2 (Drosophila) | -0.45 |
| LINGO1 | leucine rich repeat and Ig domain containing 1 | -0.44 |
| DOP1A | DOP1 leucine zipper like protein A | -0.44 |
| ENO1 | enolase 1, (alpha) | -0.43 |
| VIM | vimentin | -0.42 |
| TMEM41B | transmembrane protein 41B | -0.41 |
| ATXN1L | ataxin 1-like | -0.41 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.41 |
| RGS20 | regulator of G-protein signaling 20 | -0.41 |
| PRF1 | perforin 1 (pore forming protein) | -0.4 |
| TRAF3IP2 | TRAF3 interacting protein 2 | -0.4 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | -0.4 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -0.4 |
| KIAA0513 | KIAA0513 | -0.39 |
| BTBD11 | BTB (POZ) domain containing 11 | -0.39 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.39 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | -0.38 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | -0.38 |
| ATL1 | atlastin GTPase 1 | -0.38 |
| NDUFC2 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa | -0.38 |
| SYN1 | synapsin I | -0.37 |
| MISO1 | mitochondrial inner membrane subdomain organizer 1 | -0.37 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.37 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.37 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | -0.36 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | -0.35 |
| HRH1 | histamine receptor H1 | -0.35 |
| CCDC82 | coiled-coil domain containing 82 | -0.35 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.35 |
| IQSEC2 | IQ motif and Sec7 domain 2 | -0.35 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.35 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.34 |
| ACTBL2 | actin, beta-like 2 | -0.34 |
| DROSHA | drosha, ribonuclease type III | -0.34 |
| TNNI3 | troponin I type 3 (cardiac) | -0.33 |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | -0.33 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.33 |
| TMEM120A | transmembrane protein 120A | -0.32 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | -0.32 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.32 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.32 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.32 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.32 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.32 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.32 |
| PRDM11 | PR domain containing 11 | -0.31 |
| ANXA1 | annexin A1 | -0.31 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.31 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.31 |
| MAGEA2 | melanoma antigen family A2 | -0.3 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.3 |
| TBC1D30 | TBC1 domain family, member 30 | -0.3 |
| ZFP37 | ZFP37 zinc finger protein | -0.29 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.29 |
| RIN3 | Ras and Rab interactor 3 | -0.29 |
| FAM76A | family with sequence similarity 76, member A | -0.29 |
| MYT1L | myelin transcription factor 1-like | -0.29 |
| MTRF1 | mitochondrial translational release factor 1 | -0.29 |
| ATXN7L3B | ataxin 7-like 3B | -0.28 |
| DONSON | downstream neighbor of SON | -0.28 |
| CEP44 | centrosomal protein 44kDa | -0.28 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.28 |
| C11ORF49 | chromosome 11 open reading frame 49 | -0.28 |
| MOSPD3 | motile sperm domain containing 3 | -0.28 |
| CHRD | chordin | -0.28 |
