| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/644241 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Nilotinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CNTRL | centriolin | 3.48 |
| GSTA1 | glutathione S-transferase alpha 1 | 1.15 |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | 0.99 |
| NF1 | neurofibromin 1 | 0.97 |
| PER2 | period circadian clock 2 | 0.93 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.87 |
| KLK6 | kallikrein-related peptidase 6 | 0.85 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 0.77 |
| PRSS23 | protease, serine, 23 | 0.73 |
| DCUN1D5 | DCN1, defective in cullin neddylation 1, domain containing 5 | 0.71 |
| APOE | apolipoprotein E | 0.67 |
| SELENBP1 | selenium binding protein 1 | 0.67 |
| BHMT | betaine--homocysteine S-methyltransferase | 0.65 |
| FAR2 | fatty acyl CoA reductase 2 | 0.64 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.63 |
| OTC | ornithine carbamoyltransferase | 0.6 |
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | 0.59 |
| PAH | phenylalanine hydroxylase | 0.57 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.56 |
| RTN1 | reticulon 1 | 0.55 |
| SARDH | sarcosine dehydrogenase | 0.55 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.54 |
| CLK4 | CDC-like kinase 4 | 0.54 |
| ZNF362 | zinc finger protein 362 | 0.54 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.54 |
| CCN3 | cellular communication network factor 3 | 0.54 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | 0.52 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 | 0.52 |
| DNAAF3 | dynein, axonemal, assembly factor 3 | 0.51 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.5 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 0.5 |
| EVA1C | eva-1 homolog C (C. elegans) | 0.5 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.48 |
| ALDH1L1 | aldehyde dehydrogenase 1 family, member L1 | 0.47 |
| F8A1 | coagulation factor VIII-associated 1 | 0.46 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.46 |
| ZKSCAN3 | zinc finger with KRAB and SCAN domains 3 | 0.46 |
| TTPA | tocopherol (alpha) transfer protein | 0.45 |
| KLHL22 | kelch-like family member 22 | 0.45 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 0.45 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.45 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.45 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.45 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.45 |
| ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | 0.44 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.44 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.43 |
| TMOD2 | tropomodulin 2 (neuronal) | 0.43 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 0.42 |
| PITX2 | paired-like homeodomain 2 | 0.42 |
| UROC1 | urocanate hydratase 1 | 0.42 |
| METRN | meteorin, glial cell differentiation regulator | 0.42 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.42 |
| PPL | periplakin | 0.42 |
| DBNL | drebrin-like | 0.42 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | 0.41 |
| ARG2 | arginase 2 | 0.41 |
| LRRK1 | leucine-rich repeat kinase 1 | 0.41 |
| CLU | clusterin | 0.41 |
| KHK | ketohexokinase (fructokinase) | 0.41 |
| TLR3 | toll-like receptor 3 | 0.41 |
| ZBTB4 | zinc finger and BTB domain containing 4 | 0.41 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 0.4 |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 0.4 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 0.4 |
| TJP3 | tight junction protein 3 | 0.4 |
| ABHD2 | abhydrolase domain containing 2 | 0.4 |
| SYTL1 | synaptotagmin-like 1 | 0.4 |
| MAP2 | microtubule-associated protein 2 | 0.39 |
| DMGDH | dimethylglycine dehydrogenase | 0.38 |
| GSTM5 | glutathione S-transferase mu 5 | 0.38 |
| NGFR | nerve growth factor receptor | 0.38 |
| ZNF611 | zinc finger protein 611 | 0.38 |
| SLC39A11 | solute carrier family 39, member 11 | 0.38 |
| EPN3 | epsin 3 | 0.37 |
| ADD3 | adducin 3 (gamma) | 0.37 |
| CCDC84 | coiled-coil domain containing 84 | 0.37 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.37 |
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | 0.37 |
| BBS1 | Bardet-Biedl syndrome 1 | 0.37 |
| ULBP1 | UL16 binding protein 1 | 0.36 |
| ABAT | 4-aminobutyrate aminotransferase | 0.36 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.36 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | 0.36 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | 0.36 |
| ZFHX3 | zinc finger homeobox 3 | 0.36 |
| FAM210B | family with sequence similarity 210, member B | 0.36 |
| TLL2 | tolloid-like 2 | 0.35 |
| EXD2 | exonuclease 3'-5' domain containing 2 | 0.35 |
| SPIRE2 | spire-type actin nucleation factor 2 | 0.35 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 0.35 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | 0.35 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 0.35 |
| KITLG | KIT ligand | 0.35 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.35 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.35 |
| OSBPL2 | oxysterol binding protein-like 2 | 0.35 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.34 |
| BBS2 | Bardet-Biedl syndrome 2 | 0.34 |
| ABHD18 | abhydrolase domain containing 18 | 0.34 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RNF111 | ring finger protein 111 | -3.93 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -2.23 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -2.14 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | -1.95 |
| C12ORF60 | chromosome 12 open reading frame 60 | -1.94 |
| PRX | periaxin | -1.85 |
| CCDC158 | coiled-coil domain containing 158 | -1.5 |
| SEMG1 | semenogelin I | -1.3 |
| EGR1 | early growth response 1 | -1.18 |
| ZNF697 | zinc finger protein 697 | -1.09 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.06 |
| TMEM102 | transmembrane protein 102 | -0.91 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.91 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.88 |
| TNS4 | tensin 4 | -0.84 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.81 |
| DUSP4 | dual specificity phosphatase 4 | -0.79 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.78 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.77 |
| TSPAN3 | tetraspanin 3 | -0.77 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.71 |
| RGN | regucalcin | -0.67 |
| FOSL1 | FOS-like antigen 1 | -0.65 |
| FGB | fibrinogen beta chain | -0.64 |
| FN1 | fibronectin 1 | -0.64 |
| ETV5 | ets variant 5 | -0.64 |
| SH2B3 | SH2B adaptor protein 3 | -0.63 |
| RELL1 | RELT-like 1 | -0.63 |
| MCPH1 | microcephalin 1 | -0.62 |
| MERTK | MER proto-oncogene, tyrosine kinase | -0.61 |
| JUNB | jun B proto-oncogene | -0.6 |
| GAS6 | growth arrest-specific 6 | -0.59 |
| PIP | prolactin-induced protein | -0.59 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | -0.57 |
| ZNF628 | zinc finger protein 628 | -0.57 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.57 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | -0.56 |
| FGA | fibrinogen alpha chain | -0.55 |
| HOXB4 | homeobox B4 | -0.54 |
| EPHA2 | EPH receptor A2 | -0.54 |
| APOB | apolipoprotein B | -0.53 |
| MLPH | melanophilin | -0.53 |
| GJB3 | gap junction protein, beta 3, 31kDa | -0.52 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.52 |
| SLC38A2 | solute carrier family 38, member 2 | -0.52 |
| ZNF14 | zinc finger protein 14 | -0.51 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.5 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.5 |
| GDF15 | growth differentiation factor 15 | -0.5 |
| S100A14 | S100 calcium binding protein A14 | -0.5 |
| ZBTB7A | zinc finger and BTB domain containing 7A | -0.49 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.49 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.49 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | -0.49 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.49 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.48 |
| NCKAP1L | NCK-associated protein 1-like | -0.48 |
| MAGEA12 | melanoma antigen family A12 | -0.47 |
| TGFB1 | transforming growth factor, beta 1 | -0.46 |
| TMEM39A | transmembrane protein 39A | -0.46 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.46 |
| ZFP36 | ZFP36 ring finger protein | -0.46 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -0.46 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.45 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.45 |
| FGG | fibrinogen gamma chain | -0.44 |
| ECM1 | extracellular matrix protein 1 | -0.44 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | -0.43 |
| TMEM200A | transmembrane protein 200A | -0.43 |
| MTSS2 | MTSS I-BAR domain containing 2 | -0.43 |
| AMMECR1L | AMMECR1-like | -0.43 |
| FGF19 | fibroblast growth factor 19 | -0.42 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.42 |
| WNT10B | wingless-type MMTV integration site family, member 10B | -0.42 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.41 |
| H3-3A | H3.3 histone A | -0.41 |
| FDXACB1 | ferredoxin-fold anticodon binding domain containing 1 | -0.41 |
| WNT16 | wingless-type MMTV integration site family, member 16 | -0.41 |
| USPL1 | ubiquitin specific peptidase like 1 | -0.41 |
| DNAH2 | dynein, axonemal, heavy chain 2 | -0.41 |
| LDLR | low density lipoprotein receptor | -0.41 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.4 |
| NRP1 | neuropilin 1 | -0.4 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | -0.4 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.4 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.4 |
| SYTL3 | synaptotagmin-like 3 | -0.4 |
| PLAUR | plasminogen activator, urokinase receptor | -0.4 |
| PRF1 | perforin 1 (pore forming protein) | -0.39 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.39 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.39 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.39 |
| RUNDC1 | RUN domain containing 1 | -0.39 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | -0.39 |
| NALCN | sodium leak channel, non selective | -0.39 |
| TSPAN5 | tetraspanin 5 | -0.38 |
| CPA4 | carboxypeptidase A4 | -0.38 |
| ZNF184 | zinc finger protein 184 | -0.38 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.38 |
