Nimesulide_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nimesulide perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nimesulide_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.13613
HMGA2 high mobility group AT-hook 2 0.11041
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.085766
YAP1 Yes-associated protein 1 0.0641079
EGR1 early growth response 1 0.0558788
PFN1 profilin 1 0.0541562
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0515135
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0511169
INTS6 integrator complex subunit 6 0.0491144
FTH1 ferritin, heavy polypeptide 1 0.0489805
JMJD1C jumonji domain containing 1C 0.0484357
AREG amphiregulin 0.0482253
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0410782
RPS2 ribosomal protein S2 0.0410078
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0408881
NHSL1 NHS-like 1 0.0398309
RPS6 ribosomal protein S6 0.0380439
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0364999
RRM2 ribonucleotide reductase M2 0.0330951
TAS2R14 taste receptor, type 2, member 14 0.0325771
ASPH aspartate beta-hydroxylase 0.0320117
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.031266
RAB7A RAB7A, member RAS oncogene family 0.0285976
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0275406
MBD5 methyl-CpG binding domain protein 5 0.0273956
PCDH9 protocadherin 9 0.0270712
WWOX WW domain containing oxidoreductase 0.0269505
EHBP1 EH domain binding protein 1 0.0260093
LRMDA leucine rich melanocyte differentiation associated 0.0254864
BABAM2 BRISC and BRCA1 A complex member 2 0.0254161
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0252612
RPS14 ribosomal protein S14 0.0252567
WDPCP WD repeat containing planar cell polarity effector 0.024645
DENND5A DENN/MADD domain containing 5A 0.0245656
TPT1 tumor protein, translationally-controlled 1 0.0241997
PRH1 proline-rich protein HaeIII subfamily 1 0.0232955
EPHA5 EPH receptor A5 0.0232267
ANK2 ankyrin 2, neuronal 0.0225992
RCOR1 REST corepressor 1 0.0217402
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0214372
RPL11 ribosomal protein L11 0.0210107
EIF4H eukaryotic translation initiation factor 4H 0.0207249
RPS8 ribosomal protein S8 0.020153
MCL1 myeloid cell leukemia 1 0.0200763
NEGR1 neuronal growth regulator 1 0.0200567
HMGA1 high mobility group AT-hook 1 0.0199348
KCMF1 potassium channel modulatory factor 1 0.0199228
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0191663
RPL7 ribosomal protein L7 0.019083
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0189893
AGO3 argonaute RISC catalytic component 3 0.0188309
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0186202
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0184714
RPS23 ribosomal protein S23 0.0184398
RTN4 reticulon 4 0.0178802
ATF7 activating transcription factor 7 0.0176365
TTLL3 tubulin tyrosine ligase-like family member 3 0.0176251
VMP1 vacuole membrane protein 1 0.0176011
EXOC4 exocyst complex component 4 0.0175041
BCHE butyrylcholinesterase 0.0174953
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.017417
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0172812
PARD3B par-3 family cell polarity regulator beta 0.0171919
CCN2 cellular communication network factor 2 0.0171805
PDGFC platelet derived growth factor C 0.0171659
RPS20 ribosomal protein S20 0.016977
KTN1 kinectin 1 (kinesin receptor) 0.0169753
PRELID2 PRELI domain containing 2 0.0169613
RPL21 ribosomal protein L21 0.0168899
ASXL2 additional sex combs like transcriptional regulator 2 0.0168632
NAV3 neuron navigator 3 0.0168532
RPTOR regulatory associated protein of MTOR, complex 1 0.0167857
SERTAD2 SERTA domain containing 2 0.016741
HOMER1 homer scaffolding protein 1 0.0164009
TTC17 tetratricopeptide repeat domain 17 0.0163635
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0161777
PRELID1 PRELI domain containing 1 0.0161452
POTEF POTE ankyrin domain family, member F 0.0160481
RSU1 Ras suppressor protein 1 0.0160456
TAPBP TAP binding protein (tapasin) 0.0159857
AHRR aryl-hydrocarbon receptor repressor 0.015702
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0156804
MSRB3 methionine sulfoxide reductase B3 0.0156386
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0155637
TIMP2 TIMP metallopeptidase inhibitor 2 0.0153538
FASN fatty acid synthase 0.0153385
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0153159
RPL9 ribosomal protein L9 0.0152089
FGFR1 fibroblast growth factor receptor 1 0.0150191
RPS26 ribosomal protein S26 0.0149823
TNRC18 trinucleotide repeat containing 18 0.0149775
RPS12 ribosomal protein S12 0.0149581
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0149504
DIAPH3 diaphanous-related formin 3 0.0149271
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0148098
KIAA1328 KIAA1328 0.0147871
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0147264
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.014668
SESN2 sestrin 2 0.0146483
FOSL1 FOS-like antigen 1 0.0145404

decreased expression

Symbol Name Standardized Value
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.143508
TMSB10 thymosin beta 10 -0.119289
VIM vimentin -0.11761
CELF2 CUGBP, Elav-like family member 2 -0.105173
BIRC3 baculoviral IAP repeat containing 3 -0.10036
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0933554
ANXA1 annexin A1 -0.0894235
AHNAK AHNAK nucleoprotein -0.0884597
MMP12 matrix metallopeptidase 12 -0.0828412
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0823597
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0808157
DST dystonin -0.0775185
SLC38A2 solute carrier family 38, member 2 -0.0746875
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0728167
LOC112694756 uncharaterized LOC112694756 -0.0722525
LMO7 LIM domain 7 -0.0702056
CLDN1 claudin 1 -0.0692798
EEF2 eukaryotic translation elongation factor 2 -0.0678049
RPS27A ribosomal protein S27a -0.0650809
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.064892
PDE4D phosphodiesterase 4D, cAMP-specific -0.0648647
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0644429
ADGRG6 adhesion G protein-coupled receptor G6 -0.0599566
PTMA prothymosin, alpha -0.0591495
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0567383
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0565225
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0562274
UBC ubiquitin C -0.055045
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0533855
MYL12B myosin, light chain 12B, regulatory -0.0533662
RAD21 RAD21 homolog (S. pombe) -0.0532697
CALR calreticulin -0.0528298
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0517943
XPO1 exportin 1 -0.0514733
TOP2A topoisomerase (DNA) II alpha 170kDa -0.050467
ATP5F1B ATP synthase F1 subunit beta -0.050076
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0493254
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0481383
KDM3A lysine (K)-specific demethylase 3A -0.0479067
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0474607
BIRC6 baculoviral IAP repeat containing 6 -0.0473926
GJA1 gap junction protein, alpha 1, 43kDa -0.0472562
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0457408
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0455122
PGK1 phosphoglycerate kinase 1 -0.0452169
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0444472
ENO1 enolase 1, (alpha) -0.0441467
DLC1 DLC1 Rho GTPase activating protein -0.0434523
CANX calnexin -0.0424183
NAP1L1 nucleosome assembly protein 1-like 1 -0.0420065
KIF5B kinesin family member 5B -0.041727
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0412169
TXNRD1 thioredoxin reductase 1 -0.0411646
ZBTB20 zinc finger and BTB domain containing 20 -0.040086
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0395372
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0391138
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0387791
CARD16 caspase recruitment domain family, member 16 -0.0385997
CXADR coxsackie virus and adenovirus receptor -0.0385121
ANKRD28 ankyrin repeat domain 28 -0.0377906
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0377489
PCDH7 protocadherin 7 -0.0373405
NCAPD2 non-SMC condensin I complex, subunit D2 -0.037166
TPI1 triosephosphate isomerase 1 -0.0371125
IFIH1 interferon induced with helicase C domain 1 -0.0368815
SPAG9 sperm associated antigen 9 -0.0361982
RPL4 ribosomal protein L4 -0.0361731
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0361689
ECT2 epithelial cell transforming 2 -0.0361319
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0361042
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0359898
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.035367
ZNF217 zinc finger protein 217 -0.0353136
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0348848
PCBP2 poly(rC) binding protein 2 -0.0342301
HDLBP high density lipoprotein binding protein -0.0341621
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0338312
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0336849
DPYD dihydropyrimidine dehydrogenase -0.0334729
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0333912
LARS1 leucyl-tRNA synthetase 1 -0.0331839
CDK6 cyclin-dependent kinase 6 -0.033146
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0322181
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0320652
NCOR1 nuclear receptor corepressor 1 -0.0312438
SLC38A1 solute carrier family 38, member 1 -0.031234
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0312037
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0308449
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0305426
OXR1 oxidation resistance 1 -0.030503
U2SURP U2 snRNP-associated SURP domain containing -0.0304458
FUS FUS RNA binding protein -0.0304213
LMAN1 lectin, mannose-binding, 1 -0.0304187
USP34 ubiquitin specific peptidase 34 -0.0302606
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0300601
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0300396
RPS24 ribosomal protein S24 -0.0295779
DSPP dentin sialophosphoprotein -0.0295068
MED13L mediator complex subunit 13-like -0.0291538
MARCHF6 membrane associated ring-CH-type finger 6 -0.029115