| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Nimesulide perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Nimesulide_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.292358 |
| C3 | complement component 3 | 0.131181 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0970023 |
| RPS6 | ribosomal protein S6 | 0.0719511 |
| RPS12 | ribosomal protein S12 | 0.0691671 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0604646 |
| ZNF292 | zinc finger protein 292 | 0.0550738 |
| RPL37A | ribosomal protein L37a | 0.0548258 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0530426 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0529901 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0517614 |
| RPS8 | ribosomal protein S8 | 0.0493829 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0486658 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0460419 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0458308 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.042551 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0424613 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0406039 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0399202 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0399166 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0390358 |
| RPL7 | ribosomal protein L7 | 0.0378278 |
| RPL11 | ribosomal protein L11 | 0.0377866 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0374378 |
| RPS3 | ribosomal protein S3 | 0.0367719 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0364062 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0360583 |
| GSE1 | Gse1 coiled-coil protein | 0.0348174 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0340634 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.03399 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0338081 |
| RPL9 | ribosomal protein L9 | 0.033602 |
| HMGA1 | high mobility group AT-hook 1 | 0.0325542 |
| ARFGEF3 | ARFGEF family member 3 | 0.0320452 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0315977 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0313768 |
| GOLGA4 | golgin A4 | 0.0309642 |
| YAP1 | Yes-associated protein 1 | 0.0309463 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.0308386 |
| RPLP2 | ribosomal protein, large, P2 | 0.0298045 |
| SETD5 | SET domain containing 5 | 0.0296739 |
| VEGFA | vascular endothelial growth factor A | 0.0296334 |
| RPL3 | ribosomal protein L3 | 0.0290004 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0288935 |
| NDRG1 | N-myc downstream regulated 1 | 0.0286028 |
| APOA2 | apolipoprotein A-II | 0.0285879 |
| RPS21 | ribosomal protein S21 | 0.0281412 |
| SBF2 | SET binding factor 2 | 0.0280895 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0280774 |
| CRLS1 | cardiolipin synthase 1 | 0.0280755 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.027709 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.027517 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0274251 |
| DTNA | dystrobrevin, alpha | 0.027104 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0269911 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0268678 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0267618 |
| RPL28 | ribosomal protein L28 | 0.0263062 |
| FMNL2 | formin-like 2 | 0.026298 |
| RPS17 | ribosomal protein S17 | 0.0256943 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0256886 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0254833 |
| RPS14 | ribosomal protein S14 | 0.025482 |
| RPL5 | ribosomal protein L5 | 0.0252545 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0251475 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0250587 |
| RPL12 | ribosomal protein L12 | 0.0250204 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0249372 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0249275 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0248211 |
| USP47 | ubiquitin specific peptidase 47 | 0.0247767 |
| SDC4 | syndecan 4 | 0.0246349 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0242052 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0241089 |
| RPS2 | ribosomal protein S2 | 0.0240161 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0239886 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0239669 |
| MT2A | metallothionein 2A | 0.0236127 |
| ZFP36 | ZFP36 ring finger protein | 0.0234503 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0233959 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0232767 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0230595 |
| RPL13A | ribosomal protein L13a | 0.0229776 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0227869 |
| SFTPA2 | surfactant protein A2 | 0.0226772 |
| PRELID2 | PRELI domain containing 2 | 0.0226667 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.022485 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0223485 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0222876 |
| PDE8A | phosphodiesterase 8A | 0.0221822 |
| FAM13A | family with sequence similarity 13, member A | 0.0221709 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0219746 |
| PHF21A | PHD finger protein 21A | 0.0219352 |
| MED13L | mediator complex subunit 13-like | 0.0218968 |
| SET | SET nuclear proto-oncogene | 0.021896 |
| PFN1 | profilin 1 | 0.0218509 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0218454 |
| RANBP9 | RAN binding protein 9 | 0.0217368 |
| RNF145 | ring finger protein 145 | 0.0215913 |
| RPS13 | ribosomal protein S13 | 0.0213641 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.188637 |
| GPC6 | glypican 6 | -0.124486 |
| FN1 | fibronectin 1 | -0.124204 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.120066 |
| EHBP1 | EH domain binding protein 1 | -0.111957 |
| VCL | vinculin | -0.111762 |
| ITGAV | integrin, alpha V | -0.108423 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0940891 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0911608 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0904121 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0892697 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0735417 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0678231 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0656689 |
| BCL2L1 | BCL2-like 1 | -0.0648795 |
| APOB | apolipoprotein B | -0.0645552 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0642736 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.06135 |
| FAM107B | family with sequence similarity 107, member B | -0.0608123 |
| PEG3 | paternally expressed 3 | -0.0607628 |
| PTCHD4 | patched domain containing 4 | -0.0570603 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0566076 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0565943 |
| DST | dystonin | -0.0558295 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0551711 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0543045 |
| GPC3 | glypican 3 | -0.0518823 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0514861 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0514253 |
| DSPP | dentin sialophosphoprotein | -0.0510358 |
| ZNF644 | zinc finger protein 644 | -0.0507728 |
| MYO1E | myosin IE | -0.0505095 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0478897 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0473937 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0466513 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0466363 |
| FOXP1 | forkhead box P1 | -0.0462193 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0451696 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0434358 |
| CP | ceruloplasmin (ferroxidase) | -0.0433385 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0424169 |
| TPM4 | tropomyosin 4 | -0.0418644 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0418026 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0416064 |
| EGR1 | early growth response 1 | -0.0412421 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0408115 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0396512 |
| FRMD5 | FERM domain containing 5 | -0.0395392 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0383825 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0381838 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0379423 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0377472 |
| SMAD3 | SMAD family member 3 | -0.0374407 |
| TRIM26 | tripartite motif containing 26 | -0.0372832 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0369245 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0368639 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0362503 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.036054 |
| FAT1 | FAT atypical cadherin 1 | -0.0347578 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0335678 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0330396 |
| VMP1 | vacuole membrane protein 1 | -0.0328362 |
| ACTN4 | actinin, alpha 4 | -0.0326768 |
| THBS1 | thrombospondin 1 | -0.0326067 |
| GK | glycerol kinase | -0.0323639 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0314314 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0313981 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0311166 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.031064 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0307007 |
| RNF213 | ring finger protein 213 | -0.0304008 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0303409 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0302345 |
| ENAH | enabled homolog (Drosophila) | -0.0302301 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0297945 |
| KLF6 | Kruppel-like factor 6 | -0.029425 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0292794 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0292141 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0284498 |
| RIGI | RNA sensor RIG-I | -0.0280619 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0280484 |
| CADM1 | cell adhesion molecule 1 | -0.0280268 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0277106 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0276893 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0276824 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0276039 |
| STK17A | serine/threonine kinase 17a | -0.0275529 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0275232 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0272621 |
| TNS3 | tensin 3 | -0.0271785 |
| FILIP1L | filamin A interacting protein 1-like | -0.0271637 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.0270469 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0269679 |
| AHNAK | AHNAK nucleoprotein | -0.0267971 |
| ZFHX3 | zinc finger homeobox 3 | -0.0267594 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0267477 |
| TPM1 | tropomyosin 1 (alpha) | -0.0267172 |
| HDAC4 | histone deacetylase 4 | -0.0265268 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0260447 |
| RAI14 | retinoic acid induced 14 | -0.025995 |
