Nimesulide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nimesulide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nimesulide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.137387
FTH1 ferritin, heavy polypeptide 1 0.119858
TIMP3 TIMP metallopeptidase inhibitor 3 0.0979754
FLNB filamin B, beta 0.0977152
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0927841
MTSS1 metastasis suppressor 1 0.0884797
TGM2 transglutaminase 2 0.0867312
RPS6 ribosomal protein S6 0.081912
B2M beta-2-microglobulin 0.0762511
PDE4D phosphodiesterase 4D, cAMP-specific 0.0724888
DPYD dihydropyrimidine dehydrogenase 0.0675486
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0672005
RPS8 ribosomal protein S8 0.0624155
NDRG1 N-myc downstream regulated 1 0.0606551
MSN moesin 0.0595822
CLU clusterin 0.0579843
HSPG2 heparan sulfate proteoglycan 2 0.0574506
RASAL2 RAS protein activator like 2 0.0566166
TRIO trio Rho guanine nucleotide exchange factor 0.0564315
CD44 CD44 molecule (Indian blood group) 0.0552331
PDLIM5 PDZ and LIM domain 5 0.0547375
TPM3 tropomyosin 3 0.0526063
KTN1 kinectin 1 (kinesin receptor) 0.05209
RPL21 ribosomal protein L21 0.0507656
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0503696
EFNA5 ephrin-A5 0.0494014
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0491975
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0483077
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0471372
LMO7 LIM domain 7 0.047028
RPL11 ribosomal protein L11 0.0466781
RPL37 ribosomal protein L37 0.0453944
MCL1 myeloid cell leukemia 1 0.0449886
CDK6 cyclin-dependent kinase 6 0.0447434
HM13 histocompatibility (minor) 13 0.044555
ALCAM activated leukocyte cell adhesion molecule 0.0442403
RPS13 ribosomal protein S13 0.0430709
SLC35F3 solute carrier family 35, member F3 0.042324
EFHD2 EF-hand domain family, member D2 0.0420565
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0419699
RPS3 ribosomal protein S3 0.041709
PFN1 profilin 1 0.0396574
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0396474
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0392672
RIN2 Ras and Rab interactor 2 0.0392665
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0391993
ZSWIM6 zinc finger, SWIM-type containing 6 0.0390946
RPS2 ribosomal protein S2 0.0387815
RPL37A ribosomal protein L37a 0.037647
LAMC2 laminin, gamma 2 0.0373038
APLP2 amyloid beta (A4) precursor-like protein 2 0.0369404
RPLP2 ribosomal protein, large, P2 0.036833
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0365879
RAI14 retinoic acid induced 14 0.03624
POTEF POTE ankyrin domain family, member F 0.0357041
S100A9 S100 calcium binding protein A9 0.0351598
EGR1 early growth response 1 0.0350019
LAMA5 laminin, alpha 5 0.034595
RPL7 ribosomal protein L7 0.0341586
RPL8 ribosomal protein L8 0.033569
HMGA2 high mobility group AT-hook 2 0.0334789
RPS21 ribosomal protein S21 0.0334356
DOCK5 dedicator of cytokinesis 5 0.0333493
FNDC3B fibronectin type III domain containing 3B 0.0331395
PLS3 plastin 3 0.0329113
SFTPA2 surfactant protein A2 0.0328566
GOLGA4 golgin A4 0.0321337
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0319064
GOLGB1 golgin B1 0.0317454
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0316809
RPS14 ribosomal protein S14 0.031586
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0314168
RPS12 ribosomal protein S12 0.0314094
RABGAP1L RAB GTPase activating protein 1-like 0.031245
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0312151
NRIP1 nuclear receptor interacting protein 1 0.0311961
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0308381
MECOM MDS1 and EVI1 complex locus 0.0307517
PSD3 pleckstrin and Sec7 domain containing 3 0.0305722
EXT1 exostosin glycosyltransferase 1 0.0302022
CAV2 caveolin 2 0.030108
SRRM2 serine/arginine repetitive matrix 2 0.0295007
RPL28 ribosomal protein L28 0.0293274
PDIA3 protein disulfide isomerase family A, member 3 0.0290283
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0288228
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0287009
RACK1 receptor for activated C kinase 1 0.0285155
PODXL podocalyxin-like 0.0281663
RNF217 ring finger protein 217 0.0281401
PRSS23 protease, serine, 23 0.0279559
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0279054
N4BP2L2 NEDD4 binding protein 2-like 2 0.0277878
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0277288
KRT6A keratin 6A, type II 0.0271916
JMJD1C jumonji domain containing 1C 0.0267786
PGM3 phosphoglucomutase 3 0.0266651
RPS17 ribosomal protein S17 0.0265097
PALLD palladin, cytoskeletal associated protein 0.0264837
CEP350 centrosomal protein 350kDa 0.0263117
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0258178

decreased expression

Symbol Name Standardized Value
KRT17 keratin 17, type I -0.110588
LOC112694756 uncharaterized LOC112694756 -0.0952008
AHNAK AHNAK nucleoprotein -0.0613326
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0585905
H1-0 H1.0 linker histone -0.0531088
KDM3A lysine (K)-specific demethylase 3A -0.0454695
KRT14 keratin 14, type I -0.0442784
NAMPT nicotinamide phosphoribosyltransferase -0.0440243
MYH9 myosin, heavy chain 9, non-muscle -0.0401751
OGA O-GlcNAcase -0.0345716
APP amyloid beta (A4) precursor protein -0.0331775
ANLN anillin, actin binding protein -0.0323612
EMP1 epithelial membrane protein 1 -0.0305697
PLEC plectin -0.0293467
CAVIN1 caveolae associated protein 1 -0.0288342
CANX calnexin -0.0280201
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0277915
RLF rearranged L-myc fusion -0.0276377
TMSB4X thymosin beta 4, X-linked -0.0262238
MORF4L2 mortality factor 4 like 2 -0.0261824
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0256363
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0254448
TMSB10 thymosin beta 10 -0.0254085
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0252817
MT1X metallothionein 1X -0.0246162
ANXA1 annexin A1 -0.0242291
WSB1 WD repeat and SOCS box containing 1 -0.0238427
SPAG9 sperm associated antigen 9 -0.0224325
NPEPPS aminopeptidase puromycin sensitive -0.022278
DENND4C DENN/MADD domain containing 4C -0.0211737
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.020336
HOOK2 hook microtubule-tethering protein 2 -0.0201225
MARCHF6 membrane associated ring-CH-type finger 6 -0.0190319
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0185343
LDHA lactate dehydrogenase A -0.017795
ANKRD10 ankyrin repeat domain 10 -0.0176433
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0175087
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0174292
GM2A GM2 ganglioside activator -0.0173277
ARF1 ADP-ribosylation factor 1 -0.0172334
PTMA prothymosin, alpha -0.0168025
KRT19 keratin 19, type I -0.0167261
SYPL1 synaptophysin-like 1 -0.0167196
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0164833
OSBPL3 oxysterol binding protein-like 3 -0.0164001
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0162693
INSIG2 insulin induced gene 2 -0.0162622
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0161864
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0160793
TKT transketolase -0.0159282
USP3 ubiquitin specific peptidase 3 -0.0157047
OGFR opioid growth factor receptor -0.0156789
QKI QKI, KH domain containing, RNA binding -0.0154723
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0153193
SOD2 superoxide dismutase 2, mitochondrial -0.0151045
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0149818
RPL4 ribosomal protein L4 -0.0148701
C4BPB complement component 4 binding protein, beta -0.0148123
FSTL1 follistatin-like 1 -0.0145254
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0143688
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.014336
ANKRD33B ankyrin repeat domain 33B -0.0142282
RAB1B RAB1B, member RAS oncogene family -0.0139425
CUL4B cullin 4B -0.013914
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0138466
CD47 CD47 molecule -0.0137537
PRPF6 pre-mRNA processing factor 6 -0.0136811
SLC45A4 solute carrier family 45, member 4 -0.0135303
VDAC1 voltage-dependent anion channel 1 -0.0134293
UBE2I ubiquitin-conjugating enzyme E2I -0.0134131
IGF2 insulin-like growth factor 2 -0.0133253
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0132779
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0132537
NT5C2 5'-nucleotidase, cytosolic II -0.0132299
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0131822
CDC73 cell division cycle 73 -0.0131635
CLTB clathrin, light chain B -0.0131511
ZNF217 zinc finger protein 217 -0.0131314
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0130783
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0130347
AOPEP aminopeptidase O (putative) -0.012979
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0129456
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0128886
PLAC8 placenta-specific 8 -0.012871
HMGB2 high mobility group box 2 -0.0127227
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0127029
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0124477
GSN gelsolin -0.0120397
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0118612
IER3 immediate early response 3 -0.0118426
EIF4A2 eukaryotic translation initiation factor 4A2 -0.011827
IFI16 interferon, gamma-inducible protein 16 -0.0118125
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0116177
BZW1 basic leucine zipper and W2 domains 1 -0.011569
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -0.0115432
RAB6A RAB6A, member RAS oncogene family -0.0115052
CEPT1 choline/ethanolamine phosphotransferase 1 -0.0114669
MEF2A myocyte enhancer factor 2A -0.0111802
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0111013
PROCR protein C receptor, endothelial -0.0110487