Nimesulide_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nimesulide perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nimesulide_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.067089
ERRFI1 ERBB receptor feedback inhibitor 1 0.0574834
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0436438
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0402372
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0392555
EZR ezrin 0.0350241
CENPF centromere protein F, 350/400kDa 0.0333828
RAI1 retinoic acid induced 1 0.0304571
RTN4 reticulon 4 0.0286186
TMEM41B transmembrane protein 41B 0.0276932
GARS1 glycyl-tRNA synthetase 1 0.0264757
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0259067
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0248591
SPAG9 sperm associated antigen 9 0.0237002
JMJD1C jumonji domain containing 1C 0.0235741
NUP58 nucleoporin 58 0.0225782
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0224987
NAMPT nicotinamide phosphoribosyltransferase 0.0222788
KMT2E lysine (K)-specific methyltransferase 2E 0.0222732
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0219283
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0218638
TM4SF1 transmembrane 4 L six family member 1 0.0204172
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.020049
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0196552
ANXA1 annexin A1 0.0194669
ZNF292 zinc finger protein 292 0.0188172
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0186713
RBM39 RNA binding motif protein 39 0.0185039
MKI67 marker of proliferation Ki-67 0.0184579
CAPRIN2 caprin family member 2 0.0182992
YBX3 Y box binding protein 3 0.0181346
XPO1 exportin 1 0.0178901
PUM2 pumilio RNA-binding family member 2 0.0176771
CSNK1A1 casein kinase 1, alpha 1 0.0174676
TRIP12 thyroid hormone receptor interactor 12 0.0171913
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0171627
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0169927
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.016936
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0169359
EREG epiregulin 0.0167724
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0167588
CKAP5 cytoskeleton associated protein 5 0.0166022
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0160261
POM121 POM121 transmembrane nucleoporin 0.0158198
ADAM17 ADAM metallopeptidase domain 17 0.0157649
EIF4H eukaryotic translation initiation factor 4H 0.0157243
FMNL2 formin-like 2 0.0156497
CEP170 centrosomal protein 170kDa 0.0155229
SMC4 structural maintenance of chromosomes 4 0.0154448
ZEB1 zinc finger E-box binding homeobox 1 0.0153425
MATR3 matrin 3 0.0152741
PRRC2C proline-rich coiled-coil 2C 0.0152033
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0146799
TPX2 TPX2, microtubule-associated 0.0144699
WDR43 WD repeat domain 43 0.01426
KDM3A lysine (K)-specific demethylase 3A 0.0140826
MIS18BP1 MIS18 binding protein 1 0.0138886
RSRC2 arginine/serine-rich coiled-coil 2 0.0138434
RBM25 RNA binding motif protein 25 0.0137479
FXR1 fragile X mental retardation, autosomal homolog 1 0.0136291
OGA O-GlcNAcase 0.0135446
ATP13A3 ATPase type 13A3 0.0134794
TPM3 tropomyosin 3 0.0134605
SEC24A SEC24 family member A 0.0133653
TRA2A transformer 2 alpha homolog (Drosophila) 0.0133229
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0132047
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0130863
RLF rearranged L-myc fusion 0.0130464
WDR26 WD repeat domain 26 0.0130266
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0128037
BCLAF1 BCL2-associated transcription factor 1 0.0127905
RBM27 RNA binding motif protein 27 0.0127317
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0126876
ZFAND3 zinc finger, AN1-type domain 3 0.0125763
KMT2C lysine (K)-specific methyltransferase 2C 0.0125674
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.012564
SLC38A2 solute carrier family 38, member 2 0.0125118
FAM13B family with sequence similarity 13, member B 0.0124728
DENND5A DENN/MADD domain containing 5A 0.0124591
USP34 ubiquitin specific peptidase 34 0.0122767
SON SON DNA binding protein 0.012237
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0121487
MTF2 metal response element binding transcription factor 2 0.0121016
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0121014
RPS2 ribosomal protein S2 0.0120976
FNIP1 folliculin interacting protein 1 0.0120081
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.011927
ARHGAP29 Rho GTPase activating protein 29 0.0119022
PUM1 pumilio RNA-binding family member 1 0.0118985
CSDE1 cold shock domain containing E1, RNA-binding 0.0117673
CCNL1 cyclin L1 0.0117074
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0116523
ZFR zinc finger RNA binding protein 0.0116095
FTH1 ferritin, heavy polypeptide 1 0.0115334
NCKAP1 NCK-associated protein 1 0.0115018
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0114666
NOP58 NOP58 ribonucleoprotein 0.0114635
KIF5B kinesin family member 5B 0.0114038
RRM2 ribonucleotide reductase M2 0.011385
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.011229

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11412
TMSB10 thymosin beta 10 -0.0868842
HLA-B major histocompatibility complex, class I, B -0.0867334
VIM vimentin -0.0857873
TP63 tumor protein p63 -0.0840725
PTMA prothymosin, alpha -0.069534
FTL ferritin, light polypeptide -0.0675943
CD44 CD44 molecule (Indian blood group) -0.0671011
RPL35A ribosomal protein L35a -0.0636894
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0563817
RPL31 ribosomal protein L31 -0.0540401
MT2A metallothionein 2A -0.0464496
PSD3 pleckstrin and Sec7 domain containing 3 -0.0439264
RPL37A ribosomal protein L37a -0.0431253
CADM2 cell adhesion molecule 2 -0.0429576
ENO2 enolase 2 (gamma, neuronal) -0.0414108
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.041335
RPS6 ribosomal protein S6 -0.0406312
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0401931
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0401421
RPS8 ribosomal protein S8 -0.0395827
RPS19 ribosomal protein S19 -0.0383803
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.033652
RPL36 ribosomal protein L36 -0.0335822
RPLP2 ribosomal protein, large, P2 -0.0332218
RPLP1 ribosomal protein, large, P1 -0.0331373
RPS29 ribosomal protein S29 -0.0329664
RPS23 ribosomal protein S23 -0.032168
IFITM1 interferon induced transmembrane protein 1 -0.0320159
HLA-A major histocompatibility complex, class I, A -0.0319246
TNS3 tensin 3 -0.0316218
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0312279
IFI6 interferon, alpha-inducible protein 6 -0.03091
RPS25 ribosomal protein S25 -0.030398
HMGA1 high mobility group AT-hook 1 -0.0299825
LOC112694756 uncharaterized LOC112694756 -0.0296131
RPS13 ribosomal protein S13 -0.0291021
RPS24 ribosomal protein S24 -0.0286907
B2M beta-2-microglobulin -0.0286701
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0279774
RPL28 ribosomal protein L28 -0.027654
ACTG1 actin gamma 1 -0.0276238
LDHA lactate dehydrogenase A -0.0274854
RPL37 ribosomal protein L37 -0.0271702
RPL12 ribosomal protein L12 -0.0264028
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.026273
DLG1 discs, large homolog 1 (Drosophila) -0.0259628
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0257247
ENO1 enolase 1, (alpha) -0.025567
RPS10 ribosomal protein S10 -0.0254784
TPT1 tumor protein, translationally-controlled 1 -0.0253748
RPL26 ribosomal protein L26 -0.0253297
RPS12 ribosomal protein S12 -0.0252139
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0251861
RPL36A ribosomal protein L36a -0.0251115
RNF213 ring finger protein 213 -0.024301
DPYD dihydropyrimidine dehydrogenase -0.0241111
DST dystonin -0.0239009
RPS27A ribosomal protein S27a -0.0236544
RPS27 ribosomal protein S27 -0.0236464
EHBP1 EH domain binding protein 1 -0.0234875
RPL38 ribosomal protein L38 -0.0233983
POTEF POTE ankyrin domain family, member F -0.0233129
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0232899
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0224197
RPS17 ribosomal protein S17 -0.0224144
ISG15 ISG15 ubiquitin-like modifier -0.0219831
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0218943
RPL19 ribosomal protein L19 -0.0218372
IFIH1 interferon induced with helicase C domain 1 -0.0214033
SP100 SP100 nuclear antigen -0.0213997
RPL7A ribosomal protein L7a -0.0212321
EPHA4 EPH receptor A4 -0.0209318
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0207018
EGR1 early growth response 1 -0.0200724
PKM pyruvate kinase, muscle -0.019762
EFNA5 ephrin-A5 -0.0193233
RIGI RNA sensor RIG-I -0.0193222
RPL23 ribosomal protein L23 -0.0192735
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0190504
WARS1 tryptophanyl-tRNA synthetase 1 -0.018129
EGFR epidermal growth factor receptor -0.0179703
RPS5 ribosomal protein S5 -0.0179589
RPL27A ribosomal protein L27a -0.0179072
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.017454
CSMD3 CUB and Sushi multiple domains 3 -0.0173311
RACK1 receptor for activated C kinase 1 -0.0170941
RPS11 ribosomal protein S11 -0.0170569
HLA-E major histocompatibility complex, class I, E -0.016988
RPL9 ribosomal protein L9 -0.016783
VDAC1 voltage-dependent anion channel 1 -0.0167719
RPL27 ribosomal protein L27 -0.0166996
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0165479
ECE1 endothelin converting enzyme 1 -0.016263
CMIP c-Maf inducing protein -0.0159155
RPS15 ribosomal protein S15 -0.015893
PODXL podocalyxin-like -0.015625
CFAP299 cilia and flagella associated protein 299 -0.0152085
RPS14 ribosomal protein S14 -0.0151068
INTS6 integrator complex subunit 6 -0.0150593