| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Nimesulide perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Nimesulide_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.268014 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.223402 |
| EGFR | epidermal growth factor receptor | 0.214948 |
| NDRG1 | N-myc downstream regulated 1 | 0.0911702 |
| MCL1 | myeloid cell leukemia 1 | 0.0838678 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0805121 |
| EGR1 | early growth response 1 | 0.0725011 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.066576 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0639489 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0627254 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0608638 |
| SLTM | SAFB-like, transcription modulator | 0.059628 |
| CES1 | carboxylesterase 1 | 0.0535762 |
| LAMC2 | laminin, gamma 2 | 0.0476601 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0413927 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0412765 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0385343 |
| LAMA4 | laminin, alpha 4 | 0.0375474 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0328625 |
| BRD2 | bromodomain containing 2 | 0.0319229 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0312737 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0304184 |
| RPL3 | ribosomal protein L3 | 0.0297116 |
| INTS6 | integrator complex subunit 6 | 0.0296602 |
| TSC22D2 | TSC22 domain family, member 2 | 0.029278 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0291716 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0290209 |
| MYO1E | myosin IE | 0.0288192 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0281422 |
| ATP11A | ATPase, class VI, type 11A | 0.0278657 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0276869 |
| PCBP2 | poly(rC) binding protein 2 | 0.0274081 |
| MSN | moesin | 0.0273908 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0270838 |
| RUNX1 | runt-related transcription factor 1 | 0.0268081 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0262948 |
| VCL | vinculin | 0.0261798 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.025984 |
| OSMR | oncostatin M receptor | 0.0252033 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0250652 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0249416 |
| DSCAM | Down syndrome cell adhesion molecule | 0.024251 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0239523 |
| PKM | pyruvate kinase, muscle | 0.0237195 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0237152 |
| FAM193A | family with sequence similarity 193, member A | 0.0233239 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | 0.0231029 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.022802 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0225219 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.022492 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0222604 |
| ZNF638 | zinc finger protein 638 | 0.0217249 |
| PER2 | period circadian clock 2 | 0.0212772 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0209082 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0205444 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0203873 |
| VMP1 | vacuole membrane protein 1 | 0.020283 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0200802 |
| PTEN | phosphatase and tensin homolog | 0.0197814 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.019421 |
| PLEC | plectin | 0.0194131 |
| RCOR1 | REST corepressor 1 | 0.0193762 |
| TAPBP | TAP binding protein (tapasin) | 0.0193155 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0192775 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0192351 |
| PFN1 | profilin 1 | 0.0191778 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0191221 |
| TJP1 | tight junction protein 1 | 0.0189903 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.018839 |
| ARRDC3 | arrestin domain containing 3 | 0.0181091 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0179717 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.017498 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0174145 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0173293 |
| HYOU1 | hypoxia up-regulated 1 | 0.0173238 |
| SPCS2 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | 0.0171105 |
| HOMER1 | homer scaffolding protein 1 | 0.0169124 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0168542 |
| EFNA5 | ephrin-A5 | 0.0167705 |
| JUP | junction plakoglobin | 0.0167526 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0167284 |
| TUFT1 | tuftelin 1 | 0.0166507 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0166314 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0164442 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0163629 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0162292 |
| FBRS | fibrosin | 0.0161899 |
| FRY | furry homolog (Drosophila) | 0.0161778 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0161585 |
| TMEM165 | transmembrane protein 165 | 0.0160312 |
| SYAP1 | synapse associated protein 1 | 0.0159668 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0159521 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0159098 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0158969 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0158455 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0157939 |
| VEGFC | vascular endothelial growth factor C | 0.0157495 |
| MYO1B | myosin IB | 0.015473 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0152264 |
| ATXN1 | ataxin 1 | 0.0151569 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.130083 |
| PTMA | prothymosin, alpha | -0.0968454 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0841102 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.083197 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.08264 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0766589 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0739152 |
| RPS24 | ribosomal protein S24 | -0.073866 |
| TMSB10 | thymosin beta 10 | -0.0661379 |
| RPL35A | ribosomal protein L35a | -0.0622549 |
| PGK1 | phosphoglycerate kinase 1 | -0.0594342 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0591609 |
| TXNRD1 | thioredoxin reductase 1 | -0.0569805 |
| ASPH | aspartate beta-hydroxylase | -0.0558152 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0525439 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.052063 |
| IER3 | immediate early response 3 | -0.0503237 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0497251 |
| CANX | calnexin | -0.0494893 |
| FTL | ferritin, light polypeptide | -0.0465325 |
| H1-0 | H1.0 linker histone | -0.0463478 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0458392 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.042914 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.04116 |
| RPLP0 | ribosomal protein, large, P0 | -0.0406036 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0382696 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0378675 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0368923 |
| RAD21 | RAD21 homolog (S. pombe) | -0.036764 |
| PDE8A | phosphodiesterase 8A | -0.0353296 |
| RLF | rearranged L-myc fusion | -0.0346685 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0341274 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0334895 |
| GM2A | GM2 ganglioside activator | -0.0331678 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0330918 |
| TKT | transketolase | -0.0329599 |
| HBP1 | HMG-box transcription factor 1 | -0.0319522 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0311743 |
| RPL12 | ribosomal protein L12 | -0.0307452 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0301921 |
| RPLP1 | ribosomal protein, large, P1 | -0.030074 |
| RPS25 | ribosomal protein S25 | -0.0296561 |
| WDR45B | WD repeat domain 45B | -0.029644 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0294009 |
| MT1X | metallothionein 1X | -0.0291075 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0289683 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0287622 |
| ZFR | zinc finger RNA binding protein | -0.0286004 |
| TOP1 | topoisomerase (DNA) I | -0.0279235 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0278908 |
| RPS8 | ribosomal protein S8 | -0.0278834 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0278818 |
| BBX | bobby sox homolog (Drosophila) | -0.0274345 |
| RPL34 | ribosomal protein L34 | -0.027102 |
| AHNAK | AHNAK nucleoprotein | -0.0270931 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0270479 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0266836 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0266156 |
| NF1 | neurofibromin 1 | -0.0265437 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0265233 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0264337 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.02638 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0261385 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0260485 |
| MT2A | metallothionein 2A | -0.0255165 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0249708 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0248478 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0246212 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0245882 |
| UVRAG | UV radiation resistance associated | -0.0243632 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0239741 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0237701 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0236325 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0236199 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.023317 |
| MORF4L2 | mortality factor 4 like 2 | -0.023178 |
| LDHA | lactate dehydrogenase A | -0.0228906 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0228455 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0227582 |
| HDLBP | high density lipoprotein binding protein | -0.0226613 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.022603 |
| PTK2 | protein tyrosine kinase 2 | -0.0225114 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0222892 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0222675 |
| RPS27A | ribosomal protein S27a | -0.0222673 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.022196 |
| RPL4 | ribosomal protein L4 | -0.0221389 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0220529 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0219575 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.021766 |
| RBM39 | RNA binding motif protein 39 | -0.0217216 |
| JAK1 | Janus kinase 1 | -0.021673 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0216545 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0214661 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0214409 |
| ZNF217 | zinc finger protein 217 | -0.0212593 |
| USP3 | ubiquitin specific peptidase 3 | -0.021236 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0212235 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0211646 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0210099 |
