Nimesulide_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nimesulide perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nimesulide_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.127216
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.124878
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.115268
NDRG1 N-myc downstream regulated 1 0.112211
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0751686
FTH1 ferritin, heavy polypeptide 1 0.0680378
FTL ferritin, light polypeptide 0.0642255
RPS6 ribosomal protein S6 0.0626148
RPS23 ribosomal protein S23 0.0619681
IFI27 interferon, alpha-inducible protein 27 0.0619371
DTNA dystrobrevin, alpha 0.0601894
GOLGA4 golgin A4 0.0595216
ZFP36L1 ZFP36 ring finger protein-like 1 0.0553924
RPS8 ribosomal protein S8 0.0550067
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0539491
TPM3 tropomyosin 3 0.0525856
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0507677
APLP2 amyloid beta (A4) precursor-like protein 2 0.0494782
FBXO32 F-box protein 32 0.0482418
RPS13 ribosomal protein S13 0.0477496
EIF1 eukaryotic translation initiation factor 1 0.0469245
MSN moesin 0.0463774
VEGFA vascular endothelial growth factor A 0.0459418
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0455264
RPS12 ribosomal protein S12 0.0454778
RPL9 ribosomal protein L9 0.0445493
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0441267
MAP1B microtubule-associated protein 1B 0.0429731
RPL8 ribosomal protein L8 0.0429194
RPS3 ribosomal protein S3 0.0423898
KTN1 kinectin 1 (kinesin receptor) 0.0422817
FNDC3B fibronectin type III domain containing 3B 0.0414233
P4HB prolyl 4-hydroxylase, beta polypeptide 0.041108
PRRC2C proline-rich coiled-coil 2C 0.0398902
IGFBP3 insulin-like growth factor binding protein 3 0.0395913
HMGA1 high mobility group AT-hook 1 0.0393457
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0387682
RPL32 ribosomal protein L32 0.0386423
RPL7 ribosomal protein L7 0.0376195
RPS14 ribosomal protein S14 0.0374776
RPLP2 ribosomal protein, large, P2 0.037411
RPS17 ribosomal protein S17 0.0371611
UPP1 uridine phosphorylase 1 0.0369602
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0365942
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0362081
RCOR1 REST corepressor 1 0.0357454
CDCP1 CUB domain containing protein 1 0.0357415
S100A9 S100 calcium binding protein A9 0.035333
VIM vimentin 0.0350466
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.034231
RPS19 ribosomal protein S19 0.0340821
DSPP dentin sialophosphoprotein 0.0338002
RPS29 ribosomal protein S29 0.0334499
UBE2H ubiquitin-conjugating enzyme E2H 0.0334268
AKAP13 A kinase (PRKA) anchor protein 13 0.0332057
MT2A metallothionein 2A 0.0330894
GRB10 growth factor receptor-bound protein 10 0.0328559
RPS2 ribosomal protein S2 0.0326654
SETD5 SET domain containing 5 0.0323955
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0323802
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0312801
ELL2 elongation factor, RNA polymerase II, 2 0.0311532
RPL37A ribosomal protein L37a 0.0310714
RPL11 ribosomal protein L11 0.0302257
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0298415
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.029723
SFTPA2 surfactant protein A2 0.0297069
GOLGB1 golgin B1 0.029599
CSNK1A1 casein kinase 1, alpha 1 0.029545
PDIA3 protein disulfide isomerase family A, member 3 0.0293606
ERBIN erbb2 interacting protein 0.0290545
RPL21 ribosomal protein L21 0.0288727
SLMAP sarcolemma associated protein 0.0287083
UBA6 ubiquitin-like modifier activating enzyme 6 0.0284643
RPS27 ribosomal protein S27 0.0282825
FLNB filamin B, beta 0.0278923
UBC ubiquitin C 0.0276952
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0275909
IFI6 interferon, alpha-inducible protein 6 0.0271704
TMEM165 transmembrane protein 165 0.0270815
RPL12 ribosomal protein L12 0.0270185
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0268864
AKAP9 A kinase (PRKA) anchor protein 9 0.0268861
RPL5 ribosomal protein L5 0.0266942
MCL1 myeloid cell leukemia 1 0.0262083
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0261165
TPM4 tropomyosin 4 0.0261072
RPL28 ribosomal protein L28 0.0261038
ITCH itchy E3 ubiquitin protein ligase 0.025861
LPP LIM domain containing preferred translocation partner in lipoma 0.0253228
BBX bobby sox homolog (Drosophila) 0.0253022
EEF1G eukaryotic translation elongation factor 1 gamma 0.0253012
JUP junction plakoglobin 0.0249584
RPS10 ribosomal protein S10 0.0248526
ACTG1 actin gamma 1 0.0247275
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0246861
CENPF centromere protein F, 350/400kDa 0.0243743
SNX6 sorting nexin 6 0.0242507
RPS25 ribosomal protein S25 0.0239079
RAI14 retinoic acid induced 14 0.0238598

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.233979
FN1 fibronectin 1 -0.127654
LOC112694756 uncharaterized LOC112694756 -0.0817659
LMO7 LIM domain 7 -0.0523064
RAD21 RAD21 homolog (S. pombe) -0.045469
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0434132
TM4SF1 transmembrane 4 L six family member 1 -0.0420665
TMSB10 thymosin beta 10 -0.0413762
SDC4 syndecan 4 -0.0404243
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0391249
HMGB2 high mobility group box 2 -0.0387819
PTMA prothymosin, alpha -0.038101
PLEC plectin -0.0379914
MARCHF6 membrane associated ring-CH-type finger 6 -0.0378106
APP amyloid beta (A4) precursor protein -0.037625
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0359458
KDM3A lysine (K)-specific demethylase 3A -0.0354556
SLC38A1 solute carrier family 38, member 1 -0.035392
ARF1 ADP-ribosylation factor 1 -0.0316608
ASPH aspartate beta-hydroxylase -0.0309683
RHEB Ras homolog enriched in brain -0.0295143
CAVIN1 caveolae associated protein 1 -0.0274435
MYH9 myosin, heavy chain 9, non-muscle -0.0274425
RPL4 ribosomal protein L4 -0.0273658
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0269589
TPT1 tumor protein, translationally-controlled 1 -0.0264273
TMSB4X thymosin beta 4, X-linked -0.0262836
LAMC2 laminin, gamma 2 -0.0257613
BHLHE40 basic helix-loop-helix family, member e40 -0.0255263
GNAS GNAS complex locus -0.0250664
H1-0 H1.0 linker histone -0.0230132
KRT19 keratin 19, type I -0.0221222
CALR calreticulin -0.0218263
TMEM263 transmembrane protein 263 -0.0217745
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -0.0217664
ANXA2 annexin A2 -0.0212499
HDLBP high density lipoprotein binding protein -0.0211818
HLA-E major histocompatibility complex, class I, E -0.0209565
PGK1 phosphoglycerate kinase 1 -0.0209437
ICAM1 intercellular adhesion molecule 1 -0.0207809
CRABP2 cellular retinoic acid binding protein 2 -0.0205915
EPCAM epithelial cell adhesion molecule -0.0205712
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0203842
HSPA8 heat shock 70kDa protein 8 -0.0202619
UGDH UDP-glucose 6-dehydrogenase -0.020028
LDHA lactate dehydrogenase A -0.0199923
HSPA1B heat shock 70kDa protein 1B -0.0196468
IFI16 interferon, gamma-inducible protein 16 -0.0194751
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0192469
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0185059
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0184815
S100A6 S100 calcium binding protein A6 -0.0184366
NCOA7 nuclear receptor coactivator 7 -0.0183657
USP3 ubiquitin specific peptidase 3 -0.0180768
BZW1 basic leucine zipper and W2 domains 1 -0.0178773
RRBP1 ribosome binding protein 1 -0.0177196
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0171351
IFRD1 interferon-related developmental regulator 1 -0.0164251
IRF6 interferon regulatory factor 6 -0.0162198
RPS24 ribosomal protein S24 -0.0159857
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0158694
CCND1 cyclin D1 -0.0157562
GARS1 glycyl-tRNA synthetase 1 -0.015528
PLAU plasminogen activator, urokinase -0.0154084
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0153086
CYRIB CYFIP related Rac1 interactor B -0.0150848
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0150591
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0150529
RAB1B RAB1B, member RAS oncogene family -0.0150413
KRT18 keratin 18, type I -0.0149999
EMP1 epithelial membrane protein 1 -0.0149653
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0148175
TSC22D2 TSC22 domain family, member 2 -0.0148068
SOD2 superoxide dismutase 2, mitochondrial -0.0148033
NAMPT nicotinamide phosphoribosyltransferase -0.0146878
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0145871
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0145615
HILPDA hypoxia inducible lipid droplet-associated -0.0144326
ADAM9 ADAM metallopeptidase domain 9 -0.0141158
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0140911
CAV1 caveolin 1, caveolae protein, 22kDa -0.0140873
TFRC transferrin receptor -0.0139127
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0138119
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0135265
RPL6 ribosomal protein L6 -0.0135028
YBX3 Y box binding protein 3 -0.0134339
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0134181
KLF6 Kruppel-like factor 6 -0.0132971
SSBP2 single-stranded DNA binding protein 2 -0.0130024
AHNAK2 AHNAK nucleoprotein 2 -0.0129322
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0129238
LMNA lamin A/C -0.0127931
INPP5F inositol polyphosphate-5-phosphatase F -0.0126802
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0126222
SAMD4A sterile alpha motif domain containing 4A -0.0125284
MORF4L1 mortality factor 4 like 1 -0.0123585
AGO2 argonaute RISC catalytic component 2 -0.0122957
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0121088
CD2AP CD2-associated protein -0.0120517
HLA-C major histocompatibility complex, class I, C -0.0118826