Nimesulide_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nimesulide perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

157 genes differentially expressed following the Nimesulide_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTK2 protein tyrosine kinase 2 0.123268
RPS6 ribosomal protein S6 0.106533
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.102641
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0976509
GOLGA4 golgin A4 0.0968502
FTH1 ferritin, heavy polypeptide 1 0.0906488
NKD1 naked cuticle homolog 1 (Drosophila) 0.0902297
GPC6 glypican 6 0.0836877
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0773423
ACTG1 actin gamma 1 0.0763054
SFTPA2 surfactant protein A2 0.0732381
BIRC6 baculoviral IAP repeat containing 6 0.0704418
ZNF292 zinc finger protein 292 0.0682465
RPLP1 ribosomal protein, large, P1 0.0673436
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0668401
EGFR epidermal growth factor receptor 0.0652208
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0632779
RPS3 ribosomal protein S3 0.0631021
USP34 ubiquitin specific peptidase 34 0.0629536
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0609696
RPS23 ribosomal protein S23 0.0598722
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0592733
ITGA6 integrin, alpha 6 0.0575801
RPL35A ribosomal protein L35a 0.0550361
DSCAM Down syndrome cell adhesion molecule 0.0536483
MYH9 myosin, heavy chain 9, non-muscle 0.0525673
PDE4D phosphodiesterase 4D, cAMP-specific 0.0524116
TNS3 tensin 3 0.0513166
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0496394
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0496379
CCNI cyclin I 0.0481299
FAM13A family with sequence similarity 13, member A 0.0477688
ZBTB20 zinc finger and BTB domain containing 20 0.045972
MACF1 microtubule-actin crosslinking factor 1 0.0448713
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0445747
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0434894
EIF1 eukaryotic translation initiation factor 1 0.0425031
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0422017
ASPH aspartate beta-hydroxylase 0.0419892
ZFAND3 zinc finger, AN1-type domain 3 0.041829
PTMA prothymosin, alpha 0.0417542
ESYT2 extended synaptotagmin-like protein 2 0.041273
PGK1 phosphoglycerate kinase 1 0.0388942
RBM39 RNA binding motif protein 39 0.0386021
MYO1E myosin IE 0.0378309
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0352071
RPS21 ribosomal protein S21 0.0339993
KTN1 kinectin 1 (kinesin receptor) 0.033307
FNDC3A fibronectin type III domain containing 3A 0.0330013
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0328581
JMJD1C jumonji domain containing 1C 0.0322408
SPAG9 sperm associated antigen 9 0.0303981
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0290067
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0278217
HELZ helicase with zinc finger 0.0261616
EEF2 eukaryotic translation elongation factor 2 0.0259575
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0258541
ERRFI1 ERBB receptor feedback inhibitor 1 0.0256916
FN1 fibronectin 1 0.0254475
TM4SF1 transmembrane 4 L six family member 1 0.0252963
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0251656
RPL12 ribosomal protein L12 0.0244391
TIMP3 TIMP metallopeptidase inhibitor 3 0.023673
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0236194
OGA O-GlcNAcase 0.0218038
LPP LIM domain containing preferred translocation partner in lipoma 0.0197129
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.018219
LMO7 LIM domain 7 0.0180696
MED13 mediator complex subunit 13 0.0154875
AKAP13 A kinase (PRKA) anchor protein 13 0.0119309
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0116353
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0101028
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.00958336
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00869693
AKAP12 A kinase (PRKA) anchor protein 12 0.00828259
FLNB filamin B, beta 0.00773612
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.00657976
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.00474922
FNDC3B fibronectin type III domain containing 3B 0.00328707
GCC2 GRIP and coiled-coil domain containing 2 0.0026616
FTL ferritin, light polypeptide 0.00247995
SEC31A SEC31 homolog A (S. cerevisiae) 0.00148703
PDLIM5 PDZ and LIM domain 5 2.62979E-4
KMT2C lysine (K)-specific methyltransferase 2C 4.91781E-5

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.244215
EXT1 exostosin glycosyltransferase 1 -0.221191
HMGA2 high mobility group AT-hook 2 -0.154054
MT2A metallothionein 2A -0.128983
IGFBP3 insulin-like growth factor binding protein 3 -0.1201
CXCL8 chemokine (C-X-C motif) ligand 8 -0.109303
RPL23 ribosomal protein L23 -0.100928
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0945926
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0875429
RPS12 ribosomal protein S12 -0.0864055
IGF2 insulin-like growth factor 2 -0.085352
STC1 stanniocalcin 1 -0.0811873
EFNA5 ephrin-A5 -0.0783185
NALF1 NALCN channel auxiliary factor 1 -0.0781625
NAV2 neuron navigator 2 -0.0756523
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0691024
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.065554
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0651431
ZCCHC7 zinc finger, CCHC domain containing 7 -0.06382
MCL1 myeloid cell leukemia 1 -0.0637074
TPT1 tumor protein, translationally-controlled 1 -0.0604413
PDE10A phosphodiesterase 10A -0.0599825
NDRG1 N-myc downstream regulated 1 -0.0588322
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0577548
LAMB3 laminin, beta 3 -0.0573354
LOC112694756 uncharaterized LOC112694756 -0.0572842
RAB2A RAB2A, member RAS oncogene family -0.0551853
B2M beta-2-microglobulin -0.0543214
SMYD3 SET and MYND domain containing 3 -0.0524599
ENO1 enolase 1, (alpha) -0.0517999
TMSB10 thymosin beta 10 -0.0508401
N4BP2L2 NEDD4 binding protein 2-like 2 -0.04606
RPS25 ribosomal protein S25 -0.0454968
SAMD4A sterile alpha motif domain containing 4A -0.0445604
RPL37A ribosomal protein L37a -0.044456
CDH13 cadherin 13 -0.0430937
VIM vimentin -0.0429483
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0422398
PRKCA protein kinase C, alpha -0.0389308
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0383776
PSD3 pleckstrin and Sec7 domain containing 3 -0.0372645
RPLP2 ribosomal protein, large, P2 -0.0356736
VCL vinculin -0.0336744
PARD3 par-3 family cell polarity regulator -0.0323175
CANX calnexin -0.0275086
WSB1 WD repeat and SOCS box containing 1 -0.0274883
MYOF myoferlin -0.0269428
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0254423
ARHGAP26 Rho GTPase activating protein 26 -0.0246266
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0236167
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0234623
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0229385
LDHA lactate dehydrogenase A -0.0224376
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0215081
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0209197
RPS8 ribosomal protein S8 -0.0209133
RUNX1 runt-related transcription factor 1 -0.0208535
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0207662
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0197348
ANXA2 annexin A2 -0.0194745
DIAPH2 diaphanous-related formin 2 -0.0167685
ELL2 elongation factor, RNA polymerase II, 2 -0.0127161
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0122178
TPM4 tropomyosin 4 -0.0113843
RPS19 ribosomal protein S19 -0.0104496
NAMPT nicotinamide phosphoribosyltransferase -0.00944421
PKM pyruvate kinase, muscle -0.00770937
DST dystonin -0.00689345
NAP1L1 nucleosome assembly protein 1-like 1 -0.006759
RPL34 ribosomal protein L34 -0.00300708
ATXN1 ataxin 1 -0.00278164
RPL19 ribosomal protein L19 -4.36447E-4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.50947E-5