Nimesulide_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nimesulide perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nimesulide_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.148735
VIM vimentin 0.0936916
TRIO trio Rho guanine nucleotide exchange factor 0.0762333
SFTPA2 surfactant protein A2 0.0761995
PDE10A phosphodiesterase 10A 0.0701298
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0675179
CD44 CD44 molecule (Indian blood group) 0.0671732
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0636745
NAMPT nicotinamide phosphoribosyltransferase 0.0566234
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0563843
DST dystonin 0.0548308
FRMD4A FERM domain containing 4A 0.0530955
FNDC3B fibronectin type III domain containing 3B 0.0527302
FNIP1 folliculin interacting protein 1 0.0445804
STC1 stanniocalcin 1 0.0396144
FN1 fibronectin 1 0.0392094
GOLGA4 golgin A4 0.0391541
CADM1 cell adhesion molecule 1 0.0381579
ELL2 elongation factor, RNA polymerase II, 2 0.0367705
AKAP12 A kinase (PRKA) anchor protein 12 0.0364389
VCAN versican 0.0363436
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0363117
RND3 Rho family GTPase 3 0.035804
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0349381
SDK1 sidekick cell adhesion molecule 1 0.0338675
GLIS3 GLIS family zinc finger 3 0.0338491
ZFAND3 zinc finger, AN1-type domain 3 0.0337956
KYNU kynureninase 0.03282
JMJD1C jumonji domain containing 1C 0.0328188
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0325477
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0324404
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0321399
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0317859
NAV2 neuron navigator 2 0.0314054
ATP13A3 ATPase type 13A3 0.0306245
MXI1 MAX interactor 1, dimerization protein 0.0297056
UGCG UDP-glucose ceramide glucosyltransferase 0.0293939
HDAC9 histone deacetylase 9 0.0288358
CDH13 cadherin 13 0.0285397
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0282717
AFF4 AF4/FMR2 family, member 4 0.0281839
RPS6 ribosomal protein S6 0.02749
ZNF292 zinc finger protein 292 0.0274887
COL6A3 collagen, type VI, alpha 3 0.0274161
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026938
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0269079
RAI14 retinoic acid induced 14 0.0268843
WDFY1 WD repeat and FYVE domain containing 1 0.0268215
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0265446
LAMP2 lysosomal-associated membrane protein 2 0.0265124
FLNB filamin B, beta 0.0263048
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0256919
IGFBP3 insulin-like growth factor binding protein 3 0.0254896
ATXN1 ataxin 1 0.0251979
LOXL2 lysyl oxidase-like 2 0.0249597
TENT5A terminal nucleotidyltransferase 5A 0.0248302
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0248218
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0247694
PTBP3 polypyrimidine tract binding protein 3 0.0243013
AFF3 AF4/FMR2 family, member 3 0.0242871
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0240043
SPAG9 sperm associated antigen 9 0.0237962
FRMPD4 FERM and PDZ domain containing 4 0.0236247
ZFP36L1 ZFP36 ring finger protein-like 1 0.0236029
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0235389
LCORL ligand dependent nuclear receptor corepressor-like 0.0235089
TRIP12 thyroid hormone receptor interactor 12 0.0234263
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0234008
UBC ubiquitin C 0.023098
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0230233
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0228161
MMP12 matrix metallopeptidase 12 0.022776
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0223692
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0223691
ZSWIM6 zinc finger, SWIM-type containing 6 0.0223049
EGFR epidermal growth factor receptor 0.0220894
KDM2A lysine (K)-specific demethylase 2A 0.0220538
RB1CC1 RB1-inducible coiled-coil 1 0.0219758
IARS1 isoleucyl-tRNA synthetase 1 0.0219465
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0218978
GOLGB1 golgin B1 0.0218167
KMT2E lysine (K)-specific methyltransferase 2E 0.0212456
NDRG1 N-myc downstream regulated 1 0.0212322
UBA6 ubiquitin-like modifier activating enzyme 6 0.0209747
LOX lysyl oxidase 0.020825
WTAP Wilms tumor 1 associated protein 0.0207373
CENPF centromere protein F, 350/400kDa 0.0206022
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0205095
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0202892
ADAM12 ADAM metallopeptidase domain 12 0.0202498
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0199133
FMNL2 formin-like 2 0.0197744
CDK19 cyclin-dependent kinase 19 0.0197555
CLTC clathrin, heavy chain (Hc) 0.0196355
STAG2 stromal antigen 2 0.0195875
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0194971
NGLY1 N-glycanase 1 0.0194558
SRGN serglycin 0.0192694
USP9X ubiquitin specific peptidase 9, X-linked 0.0192643
VEGFA vascular endothelial growth factor A 0.0192324

decreased expression

Symbol Name Standardized Value
LOC112694756 uncharaterized LOC112694756 -0.0730846
MYH9 myosin, heavy chain 9, non-muscle -0.0719206
TMSB10 thymosin beta 10 -0.0594554
MT2A metallothionein 2A -0.047689
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0428443
HLA-B major histocompatibility complex, class I, B -0.0323756
SOD2 superoxide dismutase 2, mitochondrial -0.0293714
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0272327
RPL35A ribosomal protein L35a -0.0214632
RPLP1 ribosomal protein, large, P1 -0.0208613
LDHA lactate dehydrogenase A -0.0203454
ENO1 enolase 1, (alpha) -0.0198599
FTL ferritin, light polypeptide -0.018664
RPS24 ribosomal protein S24 -0.018068
RPL23 ribosomal protein L23 -0.0161133
MT1X metallothionein 1X -0.0145838
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.014373
RPL4 ribosomal protein L4 -0.014118
PKM pyruvate kinase, muscle -0.0140604
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0139914
RPL26 ribosomal protein L26 -0.0137729
IFITM1 interferon induced transmembrane protein 1 -0.0137458
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0130676
BICC1 BicC family RNA binding protein 1 -0.0128963
IFITM3 interferon induced transmembrane protein 3 -0.0127632
IER2 immediate early response 2 -0.012418
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0121897
RPS19 ribosomal protein S19 -0.0118129
RPS5 ribosomal protein S5 -0.0116414
CD63 CD63 molecule -0.011514
EGR1 early growth response 1 -0.0113186
RPL18 ribosomal protein L18 -0.0110918
RPLP2 ribosomal protein, large, P2 -0.0109315
SDC4 syndecan 4 -0.0105409
RPL36 ribosomal protein L36 -0.0103645
ACTG1 actin gamma 1 -0.0099941
NCOA7 nuclear receptor coactivator 7 -0.00996601
THBS1 thrombospondin 1 -0.00995992
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.00994463
KRT19 keratin 19, type I -0.009849
EIF4A1 eukaryotic translation initiation factor 4A1 -0.00961409
RPS4X ribosomal protein S4, X-linked -0.00959171
PTMA prothymosin, alpha -0.00947314
HMGN2 high mobility group nucleosomal binding domain 2 -0.00922049
RPS11 ribosomal protein S11 -0.00894641
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.00886245
MORF4L2 mortality factor 4 like 2 -0.00849585
KLF6 Kruppel-like factor 6 -0.00847151
TMED9 transmembrane emp24 protein transport domain containing 9 -0.00832837
DUSP12 dual specificity phosphatase 12 -0.00827181
HMGB2 high mobility group box 2 -0.00818132
ATP5F1E ATP synthase F1 subunit epsilon -0.00815021
CD59 CD59 molecule, complement regulatory protein -0.00809145
JPT2 Jupiter microtubule associated homolog 2 -0.0078739
ENO2 enolase 2 (gamma, neuronal) -0.00786231
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0078472
APP amyloid beta (A4) precursor protein -0.00782754
JUND jun D proto-oncogene -0.0077557
RPL35 ribosomal protein L35 -0.00774719
NUMA1 nuclear mitotic apparatus protein 1 -0.00769396
LOC102724023 ES1 protein homolog, mitochondrial -0.00768027
EEF2 eukaryotic translation elongation factor 2 -0.00760986
CST3 cystatin C -0.00760787
IFI16 interferon, gamma-inducible protein 16 -0.00760291
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.00747753
IFI6 interferon, alpha-inducible protein 6 -0.00746311
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.00740467
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.00712944
RPL7A ribosomal protein L7a -0.00710991
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00710306
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00694736
PABPN1 poly(A) binding protein, nuclear 1 -0.00691068
LMAN2 lectin, mannose-binding 2 -0.00684789
MTCH1 mitochondrial carrier 1 -0.0068257
RPS16 ribosomal protein S16 -0.0066245
RPL31 ribosomal protein L31 -0.00662087
RPS9 ribosomal protein S9 -0.00661965
GPX4 glutathione peroxidase 4 -0.00655432
SFXN3 sideroflexin 3 -0.006553
PRPF6 pre-mRNA processing factor 6 -0.006504
PRMT2 protein arginine methyltransferase 2 -0.00646392
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.00642302
GM2A GM2 ganglioside activator -0.00640219
CEP250 centrosomal protein 250kDa -0.00638488
HLA-C major histocompatibility complex, class I, C -0.00633821
TIMP2 TIMP metallopeptidase inhibitor 2 -0.00628302
CAVIN1 caveolae associated protein 1 -0.00625775
PCLO piccolo presynaptic cytomatrix protein -0.00622848
RBBP7 retinoblastoma binding protein 7 -0.00619149
CD47 CD47 molecule -0.00614705
SSRP1 structure specific recognition protein 1 -0.00611644
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.00602345
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -0.00599615
EXOC1 exocyst complex component 1 -0.00599285
DARS1 aspartyl-tRNA synthetase 1 -0.00598448
ISG15 ISG15 ubiquitin-like modifier -0.00594797
RPS21 ribosomal protein S21 -0.005907
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.00576082
NACA nascent polypeptide-associated complex alpha subunit -0.00575754
RPL36A ribosomal protein L36a -0.00573703