Nimesulide_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nimesulide perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nimesulide_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.286709
PTMA prothymosin, alpha 0.0863693
HILPDA hypoxia inducible lipid droplet-associated 0.0758641
IGFBP3 insulin-like growth factor binding protein 3 0.0733395
VIM vimentin 0.0668415
GOLGA4 golgin A4 0.0584703
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0564323
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0515139
SPAG9 sperm associated antigen 9 0.0514654
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0484741
NKTR natural killer cell triggering receptor 0.0469505
CXCL8 chemokine (C-X-C motif) ligand 8 0.0468295
POTEF POTE ankyrin domain family, member F 0.0437812
FTH1 ferritin, heavy polypeptide 1 0.0428372
TMSB10 thymosin beta 10 0.0423971
DERA deoxyribose-phosphate aldolase (putative) 0.0420866
ESYT2 extended synaptotagmin-like protein 2 0.0416377
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.040812
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0402495
SQSTM1 sequestosome 1 0.0400154
WAC WW domain containing adaptor with coiled-coil 0.0400046
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0398364
YBX3 Y box binding protein 3 0.0375416
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0359787
PKM pyruvate kinase, muscle 0.035854
B2M beta-2-microglobulin 0.0358391
SEC24A SEC24 family member A 0.0355784
ZMYND8 zinc finger, MYND-type containing 8 0.0355462
CCDC88A coiled-coil domain containing 88A 0.0353253
BIRC3 baculoviral IAP repeat containing 3 0.0348945
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0347244
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0343449
NAMPT nicotinamide phosphoribosyltransferase 0.0335963
ANXA1 annexin A1 0.0333061
TXNIP thioredoxin interacting protein 0.0327781
RPL37A ribosomal protein L37a 0.0324889
PNISR PNN-interacting serine/arginine-rich protein 0.032208
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0320438
CSNK1A1 casein kinase 1, alpha 1 0.0315809
ANKHD1 ankyrin repeat and KH domain containing 1 0.0311332
BASP1 brain abundant, membrane attached signal protein 1 0.0307968
RPS13 ribosomal protein S13 0.0305622
DOCK4 dedicator of cytokinesis 4 0.0299766
MT2A metallothionein 2A 0.0299544
NAP1L1 nucleosome assembly protein 1-like 1 0.0299317
KIF5B kinesin family member 5B 0.029903
KMT2E lysine (K)-specific methyltransferase 2E 0.0291275
RPS3 ribosomal protein S3 0.0288581
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0286409
MORF4L2 mortality factor 4 like 2 0.028513
RTN4 reticulon 4 0.0284323
SETD5 SET domain containing 5 0.0284078
PRRC2C proline-rich coiled-coil 2C 0.0282392
SET SET nuclear proto-oncogene 0.0282233
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0281231
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0280403
CENPF centromere protein F, 350/400kDa 0.027487
PFN1 profilin 1 0.0269054
KMT2C lysine (K)-specific methyltransferase 2C 0.026665
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0262591
PCCA propionyl CoA carboxylase, alpha polypeptide 0.026121
FAM222B family with sequence similarity 222, member B 0.026072
TXNRD1 thioredoxin reductase 1 0.0259873
TRA2A transformer 2 alpha homolog (Drosophila) 0.0259135
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.025625
NCOR1 nuclear receptor corepressor 1 0.025481
RPS23 ribosomal protein S23 0.0250893
UGCG UDP-glucose ceramide glucosyltransferase 0.0250225
DIAPH3 diaphanous-related formin 3 0.0249456
TAOK1 TAO kinase 1 0.0247846
RPL32 ribosomal protein L32 0.0245817
PACS1 phosphofurin acidic cluster sorting protein 1 0.0245098
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02448
RAB6A RAB6A, member RAS oncogene family 0.0243852
UBE2H ubiquitin-conjugating enzyme E2H 0.0242691
TBC1D23 TBC1 domain family, member 23 0.0241818
TSC22D2 TSC22 domain family, member 2 0.0235578
MCTP1 multiple C2 domains, transmembrane 1 0.0235408
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0232242
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0224131
TPX2 TPX2, microtubule-associated 0.0223094
UFL1 UFM1-specific ligase 1 0.0221288
COPA coatomer protein complex, subunit alpha 0.0220714
KDM2A lysine (K)-specific demethylase 2A 0.0220564
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0218666
TM9SF4 transmembrane 9 superfamily protein member 4 0.0217775
RPL19 ribosomal protein L19 0.0217539
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0216956
CBX3 chromobox homolog 3 0.0216838
HP1BP3 heterochromatin protein 1, binding protein 3 0.0216763
MAP1B microtubule-associated protein 1B 0.0215513
FAM168A family with sequence similarity 168, member A 0.0214475
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0213474
NF1 neurofibromin 1 0.0211744
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.021127
CSPP1 centrosome and spindle pole associated protein 1 0.021086
BABAM2 BRISC and BRCA1 A complex member 2 0.0210732
PDIA3 protein disulfide isomerase family A, member 3 0.0210663
RPS12 ribosomal protein S12 0.0209845
NGLY1 N-glycanase 1 0.0209824

decreased expression

Symbol Name Standardized Value
OSMR oncostatin M receptor -0.0508172
AHNAK AHNAK nucleoprotein -0.0406158
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0384444
SMYD3 SET and MYND domain containing 3 -0.0376432
TPT1 tumor protein, translationally-controlled 1 -0.0366485
NCEH1 neutral cholesterol ester hydrolase 1 -0.0338757
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0331357
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0317761
NIPBL Nipped-B homolog (Drosophila) -0.0299846
SMAD3 SMAD family member 3 -0.0296908
AHNAK2 AHNAK nucleoprotein 2 -0.0285459
IGF1R insulin-like growth factor 1 receptor -0.0284747
ZC3H12B zinc finger CCCH-type containing 12B -0.0284159
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0281818
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0280413
SVIL supervillin -0.0266324
HMGA2 high mobility group AT-hook 2 -0.0252703
BZW1 basic leucine zipper and W2 domains 1 -0.0251921
PRH1 proline-rich protein HaeIII subfamily 1 -0.0250714
SAMD4A sterile alpha motif domain containing 4A -0.0250516
TTC3 tetratricopeptide repeat domain 3 -0.0247832
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.024777
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0247598
ASPH aspartate beta-hydroxylase -0.0241916
RNF169 ring finger protein 169 -0.0233758
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0227551
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0224423
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0220744
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0220403
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0216406
NT5E 5'-nucleotidase, ecto (CD73) -0.0214837
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0210969
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0209493
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0209182
TMEM123 transmembrane protein 123 -0.020902
ATXN1 ataxin 1 -0.0208562
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0203283
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0199572
RORA RAR-related orphan receptor A -0.0199374
TBL1X transducin (beta)-like 1X-linked -0.01984
ANXA2 annexin A2 -0.019717
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0194688
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0193962
MBD5 methyl-CpG binding domain protein 5 -0.019387
ZFAND3 zinc finger, AN1-type domain 3 -0.0189694
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0189415
CDCP1 CUB domain containing protein 1 -0.0188975
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0187103
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0186859
FBXL7 F-box and leucine-rich repeat protein 7 -0.0186471
ZNF217 zinc finger protein 217 -0.0183605
RAI14 retinoic acid induced 14 -0.0182889
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.018178
AEBP2 AE binding protein 2 -0.0180059
MB21D2 Mab-21 domain containing 2 -0.0179999
RPL4 ribosomal protein L4 -0.0178007
BCAR3 breast cancer anti-estrogen resistance 3 -0.0175868
FASTKD2 FAST kinase domains 2 -0.017303
TAS2R14 taste receptor, type 2, member 14 -0.0172286
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0171852
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0171423
ZBTB1 zinc finger and BTB domain containing 1 -0.0170764
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0169585
NALCN sodium leak channel, non selective -0.0166881
ZC3H13 zinc finger CCCH-type containing 13 -0.0166429
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0165756
CENPP centromere protein P -0.0165065
RAD18 RAD18 E3 ubiquitin protein ligase -0.0164603
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0164083
FER fer (fps/fes related) tyrosine kinase -0.0163671
RAD21 RAD21 homolog (S. pombe) -0.0163487
INTS6 integrator complex subunit 6 -0.0163259
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0162112
NIBAN2 niban apoptosis regulator 2 -0.0162044
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0161217
ADNP activity-dependent neuroprotector homeobox -0.0160938
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 -0.0160371
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0160053
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0159587
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0159061
MYO10 myosin X -0.0158139
CLIP1 CAP-GLY domain containing linker protein 1 -0.0156051
CCND1 cyclin D1 -0.0155599
XRN1 5'-3' exoribonuclease 1 -0.0154869
STAU2 staufen double-stranded RNA binding protein 2 -0.0153702
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0153596
HLA-C major histocompatibility complex, class I, C -0.0153287
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0152836
LARP1 La ribonucleoprotein domain family, member 1 -0.0152833
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0152686
XPOT exportin, tRNA -0.0151394
RANBP17 RAN binding protein 17 -0.0151259
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0151043
FBXL2 F-box and leucine-rich repeat protein 2 -0.0150546
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.0150281
DOCK5 dedicator of cytokinesis 5 -0.0149728
ILK integrin-linked kinase -0.0149439
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.014926
VCL vinculin -0.0149091
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0147941