| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4499 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Nisoldipine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.49 |
| PHF13 | PHD finger protein 13 | 0.69 |
| GGT1 | gamma-glutamyltransferase 1 | 0.66 |
| WDR90 | WD repeat domain 90 | 0.55 |
| NUCB2 | nucleobindin 2 | 0.51 |
| ZNF484 | zinc finger protein 484 | 0.5 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.5 |
| GIN1 | gypsy retrotransposon integrase 1 | 0.48 |
| ZNF100 | zinc finger protein 100 | 0.47 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.47 |
| ZNF431 | zinc finger protein 431 | 0.45 |
| TMEM222 | transmembrane protein 222 | 0.45 |
| ZFYVE26 | zinc finger, FYVE domain containing 26 | 0.43 |
| DIABLO | diablo, IAP-binding mitochondrial protein | 0.41 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | 0.4 |
| WHAMM | WAS protein homolog associated with actin, golgi membranes and microtubules | 0.39 |
| ADIPOR1 | adiponectin receptor 1 | 0.39 |
| REPIN1 | replication initiator 1 | 0.39 |
| TYK2 | tyrosine kinase 2 | 0.38 |
| TREX1 | three prime repair exonuclease 1 | 0.38 |
| PRELID3B | PRELI domain containing 3B | 0.38 |
| MT2A | metallothionein 2A | 0.38 |
| ZNF324 | zinc finger protein 324 | 0.37 |
| INHBA | inhibin, beta A | 0.36 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.36 |
| CRLF1 | cytokine receptor-like factor 1 | 0.36 |
| FAM136A | family with sequence similarity 136, member A | 0.35 |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 | 0.35 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | 0.35 |
| FAM126A | family with sequence similarity 126, member A | 0.35 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.35 |
| ZNF33A | zinc finger protein 33A | 0.35 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.35 |
| HRAS | Harvey rat sarcoma viral oncogene homolog | 0.34 |
| MFSD14B | major facilitator superfamily domain containing 14B | 0.33 |
| KIAA0513 | KIAA0513 | 0.33 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | 0.33 |
| BSDC1 | BSD domain containing 1 | 0.33 |
| RAD54L | RAD54-like (S. cerevisiae) | 0.32 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | 0.32 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.32 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.32 |
| LMO4 | LIM domain only 4 | 0.31 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | 0.31 |
| CCDC14 | coiled-coil domain containing 14 | 0.31 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.31 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.31 |
| LRRC45 | leucine rich repeat containing 45 | 0.31 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.31 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | 0.3 |
| RNF166 | ring finger protein 166 | 0.3 |
| UPP1 | uridine phosphorylase 1 | 0.3 |
| ZNF669 | zinc finger protein 669 | 0.3 |
| METRNL | meteorin, glial cell differentiation regulator-like | 0.3 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.3 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | 0.3 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.3 |
| SPHK2 | sphingosine kinase 2 | 0.3 |
| NADK | NAD kinase | 0.3 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.3 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.29 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.29 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.29 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 0.29 |
| R3HDM4 | R3H domain containing 4 | 0.29 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | 0.28 |
| ZNF646 | zinc finger protein 646 | 0.28 |
| TMEM98 | transmembrane protein 98 | 0.28 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.28 |
| C12ORF57 | chromosome 12 open reading frame 57 | 0.28 |
| CCNF | cyclin F | 0.28 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | 0.28 |
| CDCA3 | cell division cycle associated 3 | 0.28 |
| ZNF286B | zinc finger protein 286B | 0.28 |
| RPS6KB2 | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | 0.28 |
| NR2C2AP | nuclear receptor 2C2-associated protein | 0.28 |
| KAT5 | K(lysine) acetyltransferase 5 | 0.28 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | 0.28 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.28 |
| SPRYD3 | SPRY domain containing 3 | 0.28 |
| HMBOX1 | homeobox containing 1 | 0.28 |
| AP4B1 | adaptor-related protein complex 4, beta 1 subunit | 0.27 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | 0.27 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | 0.27 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | 0.27 |
| OFD1 | oral-facial-digital syndrome 1 | 0.27 |
| FANCG | Fanconi anemia, complementation group G | 0.27 |
| GIGYF1 | GRB10 interacting GYF protein 1 | 0.27 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.27 |
| TPM4 | tropomyosin 4 | 0.27 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.26 |
| ZNF268 | zinc finger protein 268 | 0.26 |
| ZNF267 | zinc finger protein 267 | 0.26 |
| AMOT | angiomotin | 0.26 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.26 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | 0.26 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.26 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | 0.26 |
| SYTL3 | synaptotagmin-like 3 | 0.26 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.9 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.55 |
| JAG1 | jagged 1 | -0.55 |
| APOE | apolipoprotein E | -0.54 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.51 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.5 |
| ZNF740 | zinc finger protein 740 | -0.49 |
| ATP13A2 | ATPase type 13A2 | -0.48 |
| UNC80 | unc-80 homolog (C. elegans) | -0.47 |
| RNF145 | ring finger protein 145 | -0.45 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.45 |
| RARG | retinoic acid receptor, gamma | -0.41 |
| ANGPTL4 | angiopoietin-like 4 | -0.4 |
| ALDOC | aldolase C, fructose-bisphosphate | -0.4 |
| ATF3 | activating transcription factor 3 | -0.39 |
| TNNC2 | troponin C type 2 (fast) | -0.39 |
| TMEM11 | transmembrane protein 11 | -0.38 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.38 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.37 |
| MSMO1 | methylsterol monooxygenase 1 | -0.36 |
| SYK | spleen tyrosine kinase | -0.35 |
| DOCK11 | dedicator of cytokinesis 11 | -0.35 |
| JUN | jun proto-oncogene | -0.34 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | -0.34 |
| ZNF92 | zinc finger protein 92 | -0.34 |
| GGACT | gamma-glutamylamine cyclotransferase | -0.33 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.33 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.32 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.32 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.31 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | -0.31 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.31 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.31 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -0.31 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.3 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | -0.3 |
| TMEM39B | transmembrane protein 39B | -0.3 |
| UBE3B | ubiquitin protein ligase E3B | -0.3 |
| TSPAN15 | tetraspanin 15 | -0.3 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.29 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.29 |
| IL27RA | interleukin 27 receptor, alpha | -0.29 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.29 |
| NBEAL1 | neurobeachin-like 1 | -0.29 |
| NFKBIL1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | -0.28 |
| SLC39A11 | solute carrier family 39, member 11 | -0.28 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.28 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.28 |
| SNX16 | sorting nexin 16 | -0.28 |
| ERICH5 | glutamate-rich 5 | -0.28 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | -0.27 |
| MT-ATP6 | ATP synthase F0 subunit 6 | -0.27 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.27 |
| PLEK | pleckstrin | -0.27 |
| KIF21B | kinesin family member 21B | -0.27 |
| FRMPD1 | FERM and PDZ domain containing 1 | -0.26 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.26 |
| SC5D | sterol-C5-desaturase | -0.26 |
| COMMD9 | COMM domain containing 9 | -0.26 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.26 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.25 |
| CCN3 | cellular communication network factor 3 | -0.25 |
| IRF9 | interferon regulatory factor 9 | -0.25 |
| TMEM9 | transmembrane protein 9 | -0.25 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.25 |
| SLC25A30 | solute carrier family 25, member 30 | -0.25 |
| FBXW2 | F-box and WD repeat domain containing 2 | -0.25 |
| ZNF490 | zinc finger protein 490 | -0.24 |
| PRR36 | proline rich 36 | -0.24 |
| S100A10 | S100 calcium binding protein A10 | -0.24 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.24 |
| IREB2 | iron-responsive element binding protein 2 | -0.24 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.24 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.23 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | -0.23 |
| NIPSNAP3A | nipsnap homolog 3A (C. elegans) | -0.23 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.23 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.23 |
| ZNF414 | zinc finger protein 414 | -0.23 |
| FAM199X | family with sequence similarity 199, X-linked | -0.23 |
| CNTN1 | contactin 1 | -0.23 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -0.22 |
| PRMT6 | protein arginine methyltransferase 6 | -0.22 |
| SPATA2L | spermatogenesis associated 2-like | -0.22 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.22 |
| CLSTN3 | calsyntenin 3 | -0.22 |
| ABHD3 | abhydrolase domain containing 3 | -0.22 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | -0.22 |
| SQLE | squalene epoxidase | -0.22 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.22 |
| FXN | frataxin | -0.22 |
| DOCK3 | dedicator of cytokinesis 3 | -0.21 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.21 |
| CISD1 | CDGSH iron sulfur domain 1 | -0.21 |
| CRIP2 | cysteine-rich protein 2 | -0.21 |
| FADS1 | fatty acid desaturase 1 | -0.21 |
| LPCAT3 | lysophosphatidylcholine acyltransferase 3 | -0.21 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.21 |
