Nitisinone Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/115355
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Genes

200 proteins with high or low expression in Nitisinone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
GREB1 growth regulation by estrogen in breast cancer 1 1.65
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.45
MINDY4 MINDY lysine 48 deubiquitinase 4 0.43
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 0.42
BSN bassoon presynaptic cytomatrix protein 0.41
TMEM184A transmembrane protein 184A 0.39
MROH6 maestro heat-like repeat family member 6 0.38
TIGD5 tigger transposable element derived 5 0.36
NECTIN2 nectin cell adhesion molecule 2 0.36
LAMA5 laminin, alpha 5 0.35
IRX4 iroquois homeobox 4 0.34
ENO1 enolase 1, (alpha) 0.34
ISCA2 iron-sulfur cluster assembly 2 0.33
FAM20C family with sequence similarity 20, member C 0.33
ARHGAP23 Rho GTPase activating protein 23 0.33
RGS19 regulator of G-protein signaling 19 0.33
MT-ND1 NADH dehydrogenase, subunit 1 (complex I) 0.33
CASZ1 castor zinc finger 1 0.31
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.31
SRXN1 sulfiredoxin 1 0.31
DENND3 DENN/MADD domain containing 3 0.3
SYNE4 spectrin repeat containing, nuclear envelope family member 4 0.29
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 0.29
B2M beta-2-microglobulin 0.29
FGFR1OP2 FGFR1 oncogene partner 2 0.29
RNF141 ring finger protein 141 0.29
HTD2 hydroxyacyl-thioester dehydratase type 2 0.28
PHF13 PHD finger protein 13 0.28
GFOD1 glucose-fructose oxidoreductase domain containing 1 0.28
NF1 neurofibromin 1 0.28
MOCS1 molybdenum cofactor synthesis 1 0.28
CAMK1 calcium/calmodulin-dependent protein kinase I 0.27
FAM107B family with sequence similarity 107, member B 0.27
FBXO44 F-box protein 44 0.27
LRP10 low density lipoprotein receptor-related protein 10 0.26
STK36 serine/threonine kinase 36 0.26
DNAAF2 dynein, axonemal, assembly factor 2 0.26
RTL6 retrotransposon Gag like 6 0.26
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.26
NEU1 sialidase 1 (lysosomal sialidase) 0.26
TMEM38B transmembrane protein 38B 0.26
ANKRD12 ankyrin repeat domain 12 0.26
THEMIS2 thymocyte selection associated family member 2 0.26
WSB1 WD repeat and SOCS box containing 1 0.25
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 0.25
ADM adrenomedullin 0.25
PXDN peroxidasin 0.25
ABHD17C abhydrolase domain containing 17C 0.24
DONSON downstream neighbor of SON 0.24
PLXND1 plexin D1 0.23
USF1 upstream transcription factor 1 0.23
JAK3 Janus kinase 3 0.23
SETD5 SET domain containing 5 0.23
FUBP1 far upstream element (FUSE) binding protein 1 0.23
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.23
ZNF776 zinc finger protein 776 0.23
TBC1D12 TBC1 domain family, member 12 0.22
RWDD3 RWD domain containing 3 0.22
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 0.22
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.22
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 0.22
TTC39A tetratricopeptide repeat domain 39A 0.22
GID8 GID complex subunit 8 0.22
RARA retinoic acid receptor, alpha 0.22
PYGM phosphorylase, glycogen, muscle 0.22
ZBED2 zinc finger, BED-type containing 2 0.22
BPTF bromodomain PHD finger transcription factor 0.22
ADAM22 ADAM metallopeptidase domain 22 0.21
CIAO3 cytosolic iron-sulfur assembly component 3 0.21
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.21
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 0.21
CCDC28A coiled-coil domain containing 28A 0.21
ANKRD54 ankyrin repeat domain 54 0.21
PXK PX domain containing serine/threonine kinase 0.21
B9D1 B9 protein domain 1 0.2
PABPC1 poly(A) binding protein, cytoplasmic 1 0.2
CYTH3 cytohesin 3 0.2
CASKIN1 CASK interacting protein 1 0.2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.2
GRHL1 grainyhead-like 1 (Drosophila) 0.2
ZNF584 zinc finger protein 584 0.2
CA8 carbonic anhydrase VIII 0.19
RNF220 ring finger protein 220 0.19
RXRG retinoid X receptor, gamma 0.19
RAB6B RAB6B, member RAS oncogene family 0.19
SRRD SRR1 domain containing 0.19
TMC4 transmembrane channel-like 4 0.19
RPP14 ribonuclease P/MRP 14kDa subunit 0.19
TUB tubby bipartite transcription factor 0.19
PNKD paroxysmal nonkinesigenic dyskinesia 0.19
MT1L metallothionein 1L (gene/pseudogene) 0.19
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.19
EIF5A2 eukaryotic translation initiation factor 5A2 0.19
CFD complement factor D (adipsin) 0.18
AKAP6 A kinase (PRKA) anchor protein 6 0.18
CBX6 chromobox homolog 6 0.18
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.18
CCDC34 coiled-coil domain containing 34 0.18
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 0.18
ALMS1 Alstrom syndrome protein 1 0.18

low expression

Symbol Name Standardized Value
ZSCAN32 zinc finger and SCAN domain containing 32 -2.68
MED22 mediator complex subunit 22 -1.74
HBB hemoglobin, beta -1.62
TTLL4 tubulin tyrosine ligase-like family member 4 -1.36
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -1.18
PIP prolactin-induced protein -0.8
HBA1 hemoglobin, alpha 1 -0.69
PDGFC platelet derived growth factor C -0.68
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 -0.65
RMI2 RecQ mediated genome instability 2 -0.6
PRKCH protein kinase C, eta -0.59
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -0.56
FANCM Fanconi anemia, complementation group M -0.54
SPIDR scaffolding protein involved in DNA repair -0.5
CPN1 carboxypeptidase N, polypeptide 1 -0.5
USP19 ubiquitin specific peptidase 19 -0.49
BCL7B B-cell CLL/lymphoma 7B -0.48
C12ORF60 chromosome 12 open reading frame 60 -0.47
KCTD12 potassium channel tetramerization domain containing 12 -0.46
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 -0.46
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -0.45
TLL2 tolloid-like 2 -0.45
LENG9 leukocyte receptor cluster (LRC) member 9 -0.44
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 -0.44
RNF181 ring finger protein 181 -0.44
MXRA7 matrix-remodelling associated 7 -0.44
SYN2 synapsin II -0.43
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -0.43
ASB7 ankyrin repeat and SOCS box containing 7 -0.42
TTC30A tetratricopeptide repeat domain 30A -0.42
TUBAL3 tubulin, alpha-like 3 -0.41
ZNF740 zinc finger protein 740 -0.41
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -0.41
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -0.4
VWA5A von Willebrand factor A domain containing 5A -0.4
VSIR V-set immunoregulatory receptor -0.4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -0.39
KMT2B lysine (K)-specific methyltransferase 2B -0.39
ZIC2 Zic family member 2 -0.39
SNX21 sorting nexin family member 21 -0.39
PTK6 protein tyrosine kinase 6 -0.39
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.39
DMTF1 cyclin D binding myb-like transcription factor 1 -0.38
COL6A2 collagen, type VI, alpha 2 -0.38
BAG4 BCL2-associated athanogene 4 -0.38
AP4M1 adaptor-related protein complex 4, mu 1 subunit -0.38
SGSM3 small G protein signaling modulator 3 -0.38
PDE9A phosphodiesterase 9A -0.37
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.37
ZNF264 zinc finger protein 264 -0.37
DENND4B DENN/MADD domain containing 4B -0.37
SIRT3 sirtuin 3 -0.37
FBXL8 F-box and leucine-rich repeat protein 8 -0.36
FASTK Fas-activated serine/threonine kinase -0.36
ZNF175 zinc finger protein 175 -0.36
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.35
STARD3 StAR-related lipid transfer (START) domain containing 3 -0.35
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -0.34
GK glycerol kinase -0.34
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 -0.34
C9ORF40 chromosome 9 open reading frame 40 -0.34
DMWD dystrophia myotonica, WD repeat containing -0.34
TRERF1 transcriptional regulating factor 1 -0.33
NDRG2 NDRG family member 2 -0.33
ADGRE2 adhesion G protein-coupled receptor E2 -0.33
STYX serine/threonine/tyrosine interacting protein -0.33
CEP120 centrosomal protein 120kDa -0.32
CNTRL centriolin -0.32
COMMD9 COMM domain containing 9 -0.32
ZBED8 zinc finger, BED-type containing 8 -0.32
PUM2 pumilio RNA-binding family member 2 -0.32
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -0.31
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -0.31
THSD4 thrombospondin, type I, domain containing 4 -0.31
IGF1R insulin-like growth factor 1 receptor -0.31
ZBTB20 zinc finger and BTB domain containing 20 -0.31
OSGIN1 oxidative stress induced growth inhibitor 1 -0.31
DERPC DERPC proline and glycine rich nuclear protein -0.31
ZNF22 zinc finger protein 22 -0.3
SENP7 SUMO1/sentrin specific peptidase 7 -0.3
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.3
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -0.3
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -0.3
SPRED1 sprouty-related, EVH1 domain containing 1 -0.3
PRELID3B PRELI domain containing 3B -0.3
NFYB nuclear transcription factor Y, beta -0.29
SNAP91 synaptosomal-associated protein, 91kDa -0.29
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -0.29
IL6ST interleukin 6 signal transducer -0.29
APOB apolipoprotein B -0.29
ADIRF adipogenesis regulatory factor -0.29
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.29
TBC1D16 TBC1 domain family, member 16 -0.28
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.28
TSPAN33 tetraspanin 33 -0.28
LEPROTL1 leptin receptor overlapping transcript-like 1 -0.28
AMPD1 adenosine monophosphate deaminase 1 -0.28
FBXW8 F-box and WD repeat domain containing 8 -0.28
NAT14 N-acetyltransferase 14 (GCN5-related, putative) -0.28
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -0.28