Nonhomologous End-Joining (NHEJ) Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-5693571
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Genes

51 proteins participating in the Nonhomologous End-Joining (NHEJ) pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABRAXAS1 abraxas 1, BRCA1 A complex subunit
ATM ATM serine/threonine kinase
BABAM1 BRISC and BRCA1 A complex member 1
BABAM2 BRISC and BRCA1 A complex member 2
BARD1 BRCA1 associated RING domain 1
BRCA1 breast cancer 1, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
DCLRE1C DNA cross-link repair 1C
H2AX H2A.X variant histone
H2BC1 H2B clustered histone 1
H2BC11 H2B clustered histone 11
H2BC12 H2B clustered histone 12
H2BC12L H2B clustered histone 12 like
H2BC13 H2B clustered histone 13
H2BC14 H2B clustered histone 14
H2BC15 H2B clustered histone 15
H2BC17 H2B clustered histone 17
H2BC21 H2B clustered histone 21
H2BC26 H2B clustered histone 26
H2BC3 H2B clustered histone 3
H2BC4 H2B clustered histone 4
H2BC5 H2B clustered histone 5
H2BC9 H2B clustered histone 9
H3-4 H3.4 histone, cluster member
H4C1 H4 clustered histone 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
KAT5 K(lysine) acetyltransferase 5
LIG4 ligase IV, DNA, ATP-dependent
MDC1 mediator of DNA-damage checkpoint 1
MRE11 MRE11 homolog, double strand break repair nuclease
NBN nibrin
NHEJ1 nonhomologous end-joining factor 1
NSD2 nuclear receptor binding SET domain protein 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PIAS4 protein inhibitor of activated STAT, 4
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAD50 RAD50 homolog (S. cerevisiae)
RIF1 replication timing regulatory factor 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
TDP1 tyrosyl-DNA phosphodiesterase 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TP53BP1 tumor protein p53 binding protein 1
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UIMC1 ubiquitin interaction motif containing 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6