Norepinephrine (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Norepinephrine (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Norepinephrine (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.222556
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.115875
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.108408
NAV2 neuron navigator 2 0.102576
ZSWIM6 zinc finger, SWIM-type containing 6 0.102384
SMAD3 SMAD family member 3 0.0884402
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0870896
ASPH aspartate beta-hydroxylase 0.0829077
PDLIM5 PDZ and LIM domain 5 0.0799528
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0732754
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0722895
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0714592
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0703551
CREB5 cAMP responsive element binding protein 5 0.0696582
INTS6 integrator complex subunit 6 0.0689115
VCL vinculin 0.0682355
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0679832
FNDC3B fibronectin type III domain containing 3B 0.066315
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0625786
TRIO trio Rho guanine nucleotide exchange factor 0.0594165
KYNU kynureninase 0.0581299
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0570274
TPT1 tumor protein, translationally-controlled 1 0.0547586
CTBP2 C-terminal binding protein 2 0.0534909
DOCK5 dedicator of cytokinesis 5 0.0525065
HDAC9 histone deacetylase 9 0.0496208
IFI44L interferon-induced protein 44-like 0.0484663
CD44 CD44 molecule (Indian blood group) 0.0473546
EPAS1 endothelial PAS domain protein 1 0.0462091
PAX8 paired box 8 0.0454675
VIM vimentin 0.0451864
TUT7 terminal uridylyl transferase 7 0.0444852
SAMD4A sterile alpha motif domain containing 4A 0.0440394
FMNL2 formin-like 2 0.0439465
MYO1E myosin IE 0.0438517
MT2A metallothionein 2A 0.0436415
TLE4 transducin-like enhancer of split 4 0.0436367
AHNAK AHNAK nucleoprotein 0.0427045
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0421822
JAK1 Janus kinase 1 0.0421604
SEPTIN9 septin 9 0.0419687
MCL1 myeloid cell leukemia 1 0.0414008
RND3 Rho family GTPase 3 0.0412769
MSR1 macrophage scavenger receptor 1 0.0411712
B2M beta-2-microglobulin 0.0406897
UBAP2 ubiquitin associated protein 2 0.0401706
EGFR epidermal growth factor receptor 0.0394364
RPS8 ribosomal protein S8 0.0391589
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0382614
MBNL1 muscleblind-like splicing regulator 1 0.0382545
FRMD4A FERM domain containing 4A 0.0382268
GPC6 glypican 6 0.0376374
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.037469
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0373055
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0372272
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0368862
CUX1 cut-like homeobox 1 0.0362958
RIGI RNA sensor RIG-I 0.0359679
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0351061
RPL26 ribosomal protein L26 0.0349963
SP100 SP100 nuclear antigen 0.03364
DGKI diacylglycerol kinase, iota 0.0333995
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0333311
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0332042
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0331561
NUP98 nucleoporin 98kDa 0.0329589
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0328645
RNF213 ring finger protein 213 0.0328184
LYST lysosomal trafficking regulator 0.0327615
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0326253
SHB Src homology 2 domain containing adaptor protein B 0.0323109
RPL37A ribosomal protein L37a 0.0322754
HM13 histocompatibility (minor) 13 0.031648
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.03066
MRTFA myocardin related transcription factor A 0.0306441
RPL12 ribosomal protein L12 0.0306017
NRIP1 nuclear receptor interacting protein 1 0.0298802
GPR176 G protein-coupled receptor 176 0.0293142
TUSC3 tumor suppressor candidate 3 0.0293086
TJP1 tight junction protein 1 0.0292643
CRY1 cryptochrome circadian clock 1 0.0292244
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0284967
ELL2 elongation factor, RNA polymerase II, 2 0.0278727
TUFT1 tuftelin 1 0.0276132
ABTB3 ankyrin repeat and BTB domain containing 3 0.0274941
NIBAN1 niban apoptosis regulator 1 0.0274378
MYH9 myosin, heavy chain 9, non-muscle 0.0273929
WWOX WW domain containing oxidoreductase 0.0273197
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0267722
RPS17 ribosomal protein S17 0.0265567
HKDC1 hexokinase domain containing 1 0.0264438
RPS12 ribosomal protein S12 0.0264304
AFF1 AF4/FMR2 family, member 1 0.0262897
RPL9 ribosomal protein L9 0.0262068
PCBP3 poly(rC) binding protein 3 0.0261601
OSMR oncostatin M receptor 0.026012
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0260105
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.025965
ATXN1 ataxin 1 0.025875
TFPI2 tissue factor pathway inhibitor 2 0.0257928

decreased expression

Symbol Name Standardized Value
PTBP3 polypyrimidine tract binding protein 3 -0.07644
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0754231
POTEF POTE ankyrin domain family, member F -0.070822
NAMPT nicotinamide phosphoribosyltransferase -0.0703003
CP ceruloplasmin (ferroxidase) -0.067657
IGFBP3 insulin-like growth factor binding protein 3 -0.0665829
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0628806
FTH1 ferritin, heavy polypeptide 1 -0.0576305
VCAM1 vascular cell adhesion molecule 1 -0.0551724
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0533291
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0511908
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0499586
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0464188
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0445397
SP3 Sp3 transcription factor -0.0395331
FN1 fibronectin 1 -0.0392951
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0392095
PTMA prothymosin, alpha -0.038782
PLK2 polo-like kinase 2 -0.0377462
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0366616
PDIA3 protein disulfide isomerase family A, member 3 -0.0359806
SCFD2 sec1 family domain containing 2 -0.0359537
ADAM10 ADAM metallopeptidase domain 10 -0.0356272
SRPK2 SRSF protein kinase 2 -0.0354362
RAD21 RAD21 homolog (S. pombe) -0.035254
GLS2 glutaminase 2 (liver, mitochondrial) -0.0347724
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.034722
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0346074
USP3 ubiquitin specific peptidase 3 -0.0342075
GDF15 growth differentiation factor 15 -0.0341277
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0338401
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0328362
GOLGA4 golgin A4 -0.0326603
HSPB1 heat shock 27kDa protein 1 -0.0325622
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0325109
ANKRD10 ankyrin repeat domain 10 -0.0323519
TGFBI transforming growth factor, beta-induced, 68kDa -0.0314681
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0313696
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0312435
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0312033
VCAN versican -0.0311697
DENND2B DENN domain containing 2B -0.0310831
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0309803
SBF2 SET binding factor 2 -0.0308037
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0307977
MLEC malectin -0.0301672
ATP13A3 ATPase type 13A3 -0.0296001
PKM pyruvate kinase, muscle -0.0290741
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0286637
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0285816
PRRC1 proline-rich coiled-coil 1 -0.028372
BHLHE40 basic helix-loop-helix family, member e40 -0.0283148
QKI QKI, KH domain containing, RNA binding -0.0280242
OXR1 oxidation resistance 1 -0.0278627
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0278567
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0276377
UGCG UDP-glucose ceramide glucosyltransferase -0.0275168
STOM stomatin -0.0274152
GOLM2 golgi membrane protein 2 -0.0272579
GCC2 GRIP and coiled-coil domain containing 2 -0.0271071
MATR3 matrin 3 -0.0270305
ANXA4 annexin A4 -0.0266053
CD70 CD70 molecule -0.0265486
SCAF11 SR-related CTD-associated factor 11 -0.0263728
BIRC6 baculoviral IAP repeat containing 6 -0.0262557
ARRDC3 arrestin domain containing 3 -0.0258533
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 -0.0257748
NPEPPS aminopeptidase puromycin sensitive -0.0257565
PFN1 profilin 1 -0.0255605
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0255473
MARCHF6 membrane associated ring-CH-type finger 6 -0.0253729
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0252881
CLTC clathrin, heavy chain (Hc) -0.0252262
TRAM1 translocation associated membrane protein 1 -0.0252069
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.025082
RHEX regulator of hemoglobinization and erythroid cell expansion -0.024969
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0248254
EEF2 eukaryotic translation elongation factor 2 -0.0247579
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0247405
DSTN destrin (actin depolymerizing factor) -0.0247148
INSIG1 insulin induced gene 1 -0.0246984
UBXN4 UBX domain protein 4 -0.0246558
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0245142
GGNBP2 gametogenetin binding protein 2 -0.0243499
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0242057
TKT transketolase -0.0241761
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0240744
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0240144
LMAN1 lectin, mannose-binding, 1 -0.0238864
VDAC1 voltage-dependent anion channel 1 -0.0237484
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0237267
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0236965
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.023614
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.0236045
THOC2 THO complex 2 -0.0235914
PRRC2C proline-rich coiled-coil 2C -0.0232726
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0232113
HDLBP high density lipoprotein binding protein -0.0229031
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0228971
KMT2E lysine (K)-specific methyltransferase 2E -0.0228252