| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Norepinephrine (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Norepinephrine (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.168184 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.167047 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.15069 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.119522 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.110436 |
| FNDC3B | fibronectin type III domain containing 3B | 0.10407 |
| SMAD3 | SMAD family member 3 | 0.103739 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.10119 |
| FTL | ferritin, light polypeptide | 0.0896274 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0887682 |
| PDE10A | phosphodiesterase 10A | 0.0847831 |
| KYNU | kynureninase | 0.0764342 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0748476 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0746944 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0690688 |
| PTMA | prothymosin, alpha | 0.065316 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0630059 |
| FMNL2 | formin-like 2 | 0.061965 |
| SPAG9 | sperm associated antigen 9 | 0.0605549 |
| USP3 | ubiquitin specific peptidase 3 | 0.0603696 |
| ANXA1 | annexin A1 | 0.0601431 |
| ASPH | aspartate beta-hydroxylase | 0.0586939 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0570175 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0557867 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0522581 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.04986 |
| TXNRD1 | thioredoxin reductase 1 | 0.049248 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0489622 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0489006 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0479022 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0473606 |
| CMIP | c-Maf inducing protein | 0.0470174 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0463597 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0461793 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0454377 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0445529 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0439145 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.043847 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0426382 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0420844 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0413027 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0403824 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0403058 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0402836 |
| FAM107B | family with sequence similarity 107, member B | 0.0400044 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0399001 |
| BMP6 | bone morphogenetic protein 6 | 0.0398005 |
| WWOX | WW domain containing oxidoreductase | 0.0397214 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0383516 |
| TOP1 | topoisomerase (DNA) I | 0.0382868 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0373151 |
| GRAMD1B | GRAM domain containing 1B | 0.0369639 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0369457 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0367382 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0366062 |
| JAK1 | Janus kinase 1 | 0.0364394 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0362951 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0359446 |
| HELZ | helicase with zinc finger | 0.0358333 |
| WWC1 | WW and C2 domain containing 1 | 0.0357636 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0351243 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0342788 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0342705 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0342377 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0339658 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0335248 |
| MT2A | metallothionein 2A | 0.0334137 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.033357 |
| RNF145 | ring finger protein 145 | 0.0332139 |
| EREG | epiregulin | 0.0329177 |
| RHCG | Rh family, C glycoprotein | 0.0321893 |
| RTN4 | reticulon 4 | 0.0312077 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0310053 |
| PCBP2 | poly(rC) binding protein 2 | 0.0309783 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0308222 |
| FAT1 | FAT atypical cadherin 1 | 0.0307524 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0302833 |
| SSH1 | slingshot protein phosphatase 1 | 0.0302229 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.030108 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0298069 |
| NUP58 | nucleoporin 58 | 0.029771 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0297473 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0296216 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0294948 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0293922 |
| ATP13A3 | ATPase type 13A3 | 0.0293442 |
| ANGPTL4 | angiopoietin-like 4 | 0.029288 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0292524 |
| KRT7 | keratin 7, type II | 0.0291274 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0282517 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0280672 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0280301 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0279862 |
| RASA2 | RAS p21 protein activator 2 | 0.0279189 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0277634 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0276004 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.027574 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0273435 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0269786 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0269227 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.189343 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.121991 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.109289 |
| NDRG1 | N-myc downstream regulated 1 | -0.0985377 |
| TMSB10 | thymosin beta 10 | -0.0953145 |
| VIM | vimentin | -0.0795762 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0759897 |
| AHNAK | AHNAK nucleoprotein | -0.0651898 |
| S100A6 | S100 calcium binding protein A6 | -0.0560055 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0536206 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0527409 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0506819 |
| ANXA4 | annexin A4 | -0.0483157 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0465964 |
| GOLGB1 | golgin B1 | -0.0451571 |
| DAPK1 | death-associated protein kinase 1 | -0.0450751 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0449411 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0440717 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0424765 |
| RIN2 | Ras and Rab interactor 2 | -0.0415577 |
| RNF213 | ring finger protein 213 | -0.040986 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.040458 |
| EFNA5 | ephrin-A5 | -0.0390452 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0383548 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0362886 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0357866 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0350173 |
| PYGL | phosphorylase, glycogen, liver | -0.0339811 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0333677 |
| FNIP1 | folliculin interacting protein 1 | -0.0325348 |
| LAMB3 | laminin, beta 3 | -0.0322652 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0318871 |
| TPM4 | tropomyosin 4 | -0.0316799 |
| ATG7 | autophagy related 7 | -0.0314397 |
| LAMC2 | laminin, gamma 2 | -0.0311104 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0308056 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0298067 |
| GOLGA3 | golgin A3 | -0.0294911 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0290172 |
| CA12 | carbonic anhydrase XII | -0.0289164 |
| HDLBP | high density lipoprotein binding protein | -0.0280071 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0279863 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0279633 |
| HM13 | histocompatibility (minor) 13 | -0.0277895 |
| RIGI | RNA sensor RIG-I | -0.0276075 |
| URI1 | URI1, prefoldin-like chaperone | -0.027352 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0271909 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0269983 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0267527 |
| ZNF609 | zinc finger protein 609 | -0.026566 |
| SQSTM1 | sequestosome 1 | -0.0264664 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.0262973 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0261892 |
| PLEC | plectin | -0.0257526 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0257476 |
| GOLGA4 | golgin A4 | -0.0253837 |
| EFL1 | elongation factor like GTPase 1 | -0.0253206 |
| PMM2 | phosphomannomutase 2 | -0.0244992 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0239849 |
| CP | ceruloplasmin (ferroxidase) | -0.0236966 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0236723 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.023271 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0232485 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0232159 |
| TNS1 | tensin 1 | -0.0229711 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.022723 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0225489 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0225095 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0224468 |
| HLA-B | major histocompatibility complex, class I, B | -0.0223153 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0222866 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0220572 |
| RAI14 | retinoic acid induced 14 | -0.0219582 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0219226 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0219133 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0218734 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | -0.0217812 |
| TMEM263 | transmembrane protein 263 | -0.0214991 |
| GDI2 | GDP dissociation inhibitor 2 | -0.0214105 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0210146 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0209973 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.0207652 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.020703 |
| FBXO11 | F-box protein 11 | -0.0205139 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0204433 |
| OPTN | optineurin | -0.0202974 |
| AUTS2 | autism susceptibility candidate 2 | -0.0202318 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0201776 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0201272 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0200785 |
| NTRK3 | neurotrophic tyrosine kinase, receptor, type 3 | -0.0199232 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0198211 |
| C1D | C1D nuclear receptor corepressor | -0.0196745 |
| ITSN2 | intersectin 2 | -0.019631 |
| PCED1B | PC-esterase domain containing 1B | -0.0192842 |
| TNS3 | tensin 3 | -0.0190722 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0190504 |
| RRBP1 | ribosome binding protein 1 | -0.0189042 |
| FBXO17 | F-box protein 17 | -0.0188116 |
| EGFR | epidermal growth factor receptor | -0.018738 |
