Norepinephrine (hydrochloride)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Norepinephrine (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Norepinephrine (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CLTC clathrin, heavy chain (Hc) 0.124519
NCOA3 nuclear receptor coactivator 3 0.113147
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.101798
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0982216
RPL23 ribosomal protein L23 0.0869213
FNDC3A fibronectin type III domain containing 3A 0.0771959
ITCH itchy E3 ubiquitin protein ligase 0.072026
RAB7A RAB7A, member RAS oncogene family 0.0695312
SMYD3 SET and MYND domain containing 3 0.0650646
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0622844
CEMIP cell migration inducing protein, hyaluronan binding 0.0621196
TSC22D2 TSC22 domain family, member 2 0.0560628
AHNAK AHNAK nucleoprotein 0.0550977
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0540211
LDHA lactate dehydrogenase A 0.0538976
NDRG1 N-myc downstream regulated 1 0.0525186
VCL vinculin 0.0521505
CEP250 centrosomal protein 250kDa 0.05135
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0503011
ATAD2 ATPase family, AAA domain containing 2 0.0485695
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0484336
INTS6 integrator complex subunit 6 0.0479469
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0473329
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0469024
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0457267
CSNK1A1 casein kinase 1, alpha 1 0.0452454
TRIO trio Rho guanine nucleotide exchange factor 0.0451916
PDLIM5 PDZ and LIM domain 5 0.0450256
NABP1 nucleic acid binding protein 1 0.0432006
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0426529
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0419706
LARP4B La ribonucleoprotein domain family, member 4B 0.041675
LPP LIM domain containing preferred translocation partner in lipoma 0.0411194
ENO1 enolase 1, (alpha) 0.040571
RUNX1 runt-related transcription factor 1 0.0405036
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0403901
ZSWIM6 zinc finger, SWIM-type containing 6 0.0397347
IPO7 importin 7 0.0391943
LIMCH1 LIM and calponin homology domains 1 0.0386838
TOP2A topoisomerase (DNA) II alpha 170kDa 0.038545
KRT86 keratin 86, type II 0.0376812
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0374189
MYH9 myosin, heavy chain 9, non-muscle 0.0371159
ANKRD17 ankyrin repeat domain 17 0.0369415
RPS3 ribosomal protein S3 0.0368315
GRB10 growth factor receptor-bound protein 10 0.0367014
SHROOM3 shroom family member 3 0.0362893
SPAG9 sperm associated antigen 9 0.0357972
SBF2 SET binding factor 2 0.0356666
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.035392
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.03509
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0342907
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0340203
MYOF myoferlin 0.0338968
CREB5 cAMP responsive element binding protein 5 0.0337847
PAWR PRKC, apoptosis, WT1, regulator 0.0334224
ERRFI1 ERBB receptor feedback inhibitor 1 0.0333229
YAP1 Yes-associated protein 1 0.0331192
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0330411
MCL1 myeloid cell leukemia 1 0.0330282
APP amyloid beta (A4) precursor protein 0.0328785
MYO10 myosin X 0.0326211
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.032495
DSCAM Down syndrome cell adhesion molecule 0.0322354
HIPK2 homeodomain interacting protein kinase 2 0.032179
PCBP2 poly(rC) binding protein 2 0.0319288
EIF4A2 eukaryotic translation initiation factor 4A2 0.0319088
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0318215
SAMD4A sterile alpha motif domain containing 4A 0.0317474
DENND5A DENN/MADD domain containing 5A 0.0316761
KRT8 keratin 8, type II 0.0312298
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.0312001
RCOR1 REST corepressor 1 0.0308815
ATF6 activating transcription factor 6 0.0305299
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0301276
ECT2 epithelial cell transforming 2 0.0300896
SGMS1 sphingomyelin synthase 1 0.029887
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0296194
ACTN1 actinin, alpha 1 0.0295988
STK4 serine/threonine kinase 4 0.0294691
AZIN1 antizyme inhibitor 1 0.0290932
POU2F1 POU class 2 homeobox 1 0.0290736
DTNA dystrobrevin, alpha 0.0289274
AGO2 argonaute RISC catalytic component 2 0.0286784
FAM168A family with sequence similarity 168, member A 0.0285713
HSPA8 heat shock 70kDa protein 8 0.0283364
STOM stomatin 0.0281085
CEMIP2 cell migration inducing hyaluronidase 2 0.0280912
HMGB2 high mobility group box 2 0.0280816
EIF4A1 eukaryotic translation initiation factor 4A1 0.0278639
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0277723
STRN3 striatin, calmodulin binding protein 3 0.0274798
EXT1 exostosin glycosyltransferase 1 0.0274192
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0273884
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0273386
NOTCH2 notch 2 0.0273356
MACF1 microtubule-actin crosslinking factor 1 0.0272731
PLK2 polo-like kinase 2 0.0271779
HELZ helicase with zinc finger 0.0271478
DUSP16 dual specificity phosphatase 16 0.0270038

decreased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 -0.168879
PTMA prothymosin, alpha -0.119166
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.114512
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0952253
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0930143
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0922649
ACACA acetyl-CoA carboxylase alpha -0.0893442
PBX1 pre-B-cell leukemia homeobox 1 -0.0874322
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0821417
FTH1 ferritin, heavy polypeptide 1 -0.0711589
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0670442
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0635084
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0584473
ANKRD36C ankyrin repeat domain 36C -0.0575444
RPL19 ribosomal protein L19 -0.0568497
LOC102724023 ES1 protein homolog, mitochondrial -0.0563067
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0551477
S100A8 S100 calcium binding protein A8 -0.0517439
GRB7 growth factor receptor-bound protein 7 -0.0498783
FBXL20 F-box and leucine-rich repeat protein 20 -0.04908
LASP1 LIM and SH3 protein 1 -0.0486989
TMSB10 thymosin beta 10 -0.0476866
MT2A metallothionein 2A -0.0474247
TC2N tandem C2 domains, nuclear -0.0462065
S100A9 S100 calcium binding protein A9 -0.0451922
THSD4 thrombospondin, type I, domain containing 4 -0.0435696
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0434476
TRPS1 trichorhinophalangeal syndrome I -0.0419299
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0410924
FADS2 fatty acid desaturase 2 -0.0409582
RPLP1 ribosomal protein, large, P1 -0.0399545
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0394967
RPS6 ribosomal protein S6 -0.0392346
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0389283
GNAS GNAS complex locus -0.0384875
CCND1 cyclin D1 -0.0382036
RPS29 ribosomal protein S29 -0.0377704
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0374366
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0373966
RIMS2 regulating synaptic membrane exocytosis 2 -0.0360862
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0360082
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.034851
HLA-B major histocompatibility complex, class I, B -0.0339204
OSMR oncostatin M receptor -0.0337795
RPL35A ribosomal protein L35a -0.0327693
FDPS farnesyl diphosphate synthase -0.0327685
FASN fatty acid synthase -0.0314873
TAOK3 TAO kinase 3 -0.0310791
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0309691
MDK midkine (neurite growth-promoting factor 2) -0.0309607
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0307715
NCOA7 nuclear receptor coactivator 7 -0.0305508
TXNRD1 thioredoxin reductase 1 -0.0305369
IER3 immediate early response 3 -0.0304351
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0303664
BCAS1 breast carcinoma amplified sequence 1 -0.0302277
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0301632
BCAS3 breast carcinoma amplified sequence 3 -0.0294578
INSIG1 insulin induced gene 1 -0.0293288
SMIM14 small integral membrane protein 14 -0.0291813
ZNF217 zinc finger protein 217 -0.0291604
BPTF bromodomain PHD finger transcription factor -0.0291103
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0284805
TMC5 transmembrane channel-like 5 -0.028119
STAU1 staufen double-stranded RNA binding protein 1 -0.028003
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0279066
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0275054
RAB27B RAB27B, member RAS oncogene family -0.02745
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.0272403
RPL8 ribosomal protein L8 -0.0272121
TNS3 tensin 3 -0.0271428
TMEM45B transmembrane protein 45B -0.0267835
DSTN destrin (actin depolymerizing factor) -0.0267239
RPL34 ribosomal protein L34 -0.0264393
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.026407
SAMD12 sterile alpha motif domain containing 12 -0.0262933
AGR2 anterior gradient 2 -0.0261611
TMSB4X thymosin beta 4, X-linked -0.0257515
KAZN kazrin, periplakin interacting protein -0.0255717
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.025333
HMGB1 high mobility group box 1 -0.0252831
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0252259
RRBP1 ribosome binding protein 1 -0.0251309
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0249105
RPS15 ribosomal protein S15 -0.0248244
SLC38A1 solute carrier family 38, member 1 -0.0245244
ARHGAP29 Rho GTPase activating protein 29 -0.0243018
CCNI cyclin I -0.0241984
S100A14 S100 calcium binding protein A14 -0.0240759
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0239117
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0238999
B2M beta-2-microglobulin -0.0237526
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0235817
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0232638
CCSER1 coiled-coil serine-rich protein 1 -0.023231
SLFN5 schlafen family member 5 -0.0231411
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0230554
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0227682
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0227434
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0227364