Norepinephrine (hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Norepinephrine (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Norepinephrine (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.231457
TRIO trio Rho guanine nucleotide exchange factor 0.109569
NALF1 NALCN channel auxiliary factor 1 0.108453
ERBIN erbb2 interacting protein 0.0974478
FNDC3B fibronectin type III domain containing 3B 0.0640253
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0638923
INTS6 integrator complex subunit 6 0.0611481
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0592257
DST dystonin 0.0574065
ZSWIM6 zinc finger, SWIM-type containing 6 0.055116
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0538318
PDLIM5 PDZ and LIM domain 5 0.05105
ASPH aspartate beta-hydroxylase 0.0502757
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0497117
PICALM phosphatidylinositol binding clathrin assembly protein 0.0489314
VCL vinculin 0.0471979
PALM2AKAP2 PALM2 and AKAP2 fusion 0.047003
SLIT2 slit homolog 2 (Drosophila) 0.046161
LPP LIM domain containing preferred translocation partner in lipoma 0.0443983
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0441707
CD44 CD44 molecule (Indian blood group) 0.043666
NAV2 neuron navigator 2 0.0432111
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0425481
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0412242
WNT5B wingless-type MMTV integration site family, member 5B 0.040778
VEGFC vascular endothelial growth factor C 0.0403489
CALD1 caldesmon 1 0.0387572
TLE4 transducin-like enhancer of split 4 0.0385292
MYH9 myosin, heavy chain 9, non-muscle 0.0384946
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0384005
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0380661
BCAR3 breast cancer anti-estrogen resistance 3 0.0363363
SMYD3 SET and MYND domain containing 3 0.0357546
SH3RF1 SH3 domain containing ring finger 1 0.0353834
AHNAK AHNAK nucleoprotein 0.0342968
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.03421
ACTN1 actinin, alpha 1 0.0340047
NEK7 NIMA-related kinase 7 0.0334036
STARD13 StAR-related lipid transfer (START) domain containing 13 0.03307
PTPRG protein tyrosine phosphatase, receptor type, G 0.0327416
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0325895
MBNL1 muscleblind-like splicing regulator 1 0.0320687
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0313523
SAMD4A sterile alpha motif domain containing 4A 0.030821
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0306438
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0305249
PTK2 protein tyrosine kinase 2 0.0299613
KLF12 Kruppel-like factor 12 0.0299606
PBX3 pre-B-cell leukemia homeobox 3 0.029814
CD59 CD59 molecule, complement regulatory protein 0.0295875
PRELID2 PRELI domain containing 2 0.0292281
RAD51B RAD51 paralog B 0.0288053
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0285048
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0278457
HEG1 heart development protein with EGF-like domains 1 0.0278389
COL7A1 collagen, type VII, alpha 1 0.0278191
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0273449
TENM3 teneurin transmembrane protein 3 0.0272522
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0272055
RASAL2 RAS protein activator like 2 0.0269774
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0269461
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0269351
GLIS3 GLIS family zinc finger 3 0.0268612
PLSCR1 phospholipid scramblase 1 0.0268453
PTPRK protein tyrosine phosphatase, receptor type, K 0.0267084
FHIT fragile histidine triad 0.0262631
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0259813
PODXL podocalyxin-like 0.0259702
FRMD6 FERM domain containing 6 0.025804
VGLL3 vestigial-like family member 3 0.0252714
DOCK5 dedicator of cytokinesis 5 0.0249228
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0248467
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0248233
DIAPH3 diaphanous-related formin 3 0.024654
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0246368
MB21D2 Mab-21 domain containing 2 0.0242414
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0240894
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.023936
FLNB filamin B, beta 0.0239348
TPM1 tropomyosin 1 (alpha) 0.0237305
RIGI RNA sensor RIG-I 0.0234162
CLIC4 chloride intracellular channel 4 0.0233884
CORO1C coronin, actin binding protein, 1C 0.0231748
NABP1 nucleic acid binding protein 1 0.0231118
COL5A1 collagen, type V, alpha 1 0.0229332
TGFB2 transforming growth factor, beta 2 0.0229098
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0228149
SDK1 sidekick cell adhesion molecule 1 0.0225249
EXOC4 exocyst complex component 4 0.0225195
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0224705
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0224601
FER fer (fps/fes related) tyrosine kinase 0.0223457
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0219048
TRIP12 thyroid hormone receptor interactor 12 0.0218847
WWOX WW domain containing oxidoreductase 0.021851
RUNX1 runt-related transcription factor 1 0.0217431
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0214819
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0212285
ATXN1 ataxin 1 0.0211563
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0210052

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162101
FTL ferritin, light polypeptide -0.149446
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.10844
HLA-B major histocompatibility complex, class I, B -0.0956157
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0881115
FTH1 ferritin, heavy polypeptide 1 -0.0848103
IGFBP3 insulin-like growth factor binding protein 3 -0.0744508
NDRG1 N-myc downstream regulated 1 -0.0578644
PDIA3 protein disulfide isomerase family A, member 3 -0.0504749
PTMA prothymosin, alpha -0.0484332
RPS6 ribosomal protein S6 -0.0454624
UGCG UDP-glucose ceramide glucosyltransferase -0.0435955
GOLGA4 golgin A4 -0.0424087
NAMPT nicotinamide phosphoribosyltransferase -0.037545
DEK DEK proto-oncogene -0.036645
EIF1 eukaryotic translation initiation factor 1 -0.0321187
PLIN2 perilipin 2 -0.0317593
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0312188
CALR calreticulin -0.0309772
RIOK3 RIO kinase 3 -0.0295633
RPLP2 ribosomal protein, large, P2 -0.0286377
PKM pyruvate kinase, muscle -0.0283098
RPL35A ribosomal protein L35a -0.0278249
LOC112694756 uncharaterized LOC112694756 -0.0275971
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0271194
HLA-A major histocompatibility complex, class I, A -0.0257216
ADM adrenomedullin -0.0256596
MT2A metallothionein 2A -0.0253499
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0248018
F3 coagulation factor III (thromboplastin, tissue factor) -0.0244048
FOSL1 FOS-like antigen 1 -0.0243285
VIM vimentin -0.0238456
B2M beta-2-microglobulin -0.0237983
CANX calnexin -0.0234654
RPL12 ribosomal protein L12 -0.0234237
MKI67 marker of proliferation Ki-67 -0.0229522
ENO1 enolase 1, (alpha) -0.0227202
IFITM3 interferon induced transmembrane protein 3 -0.0227049
TMSB10 thymosin beta 10 -0.0226175
ZFR zinc finger RNA binding protein -0.0225576
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0223618
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0222641
RPLP1 ribosomal protein, large, P1 -0.0221879
RPL35 ribosomal protein L35 -0.0216676
LMAN1 lectin, mannose-binding, 1 -0.0213437
RPL19 ribosomal protein L19 -0.0212448
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0212446
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0206668
ANXA1 annexin A1 -0.0205629
MMP12 matrix metallopeptidase 12 -0.0205539
RPS13 ribosomal protein S13 -0.0202401
HMGB1 high mobility group box 1 -0.0202231
NUP58 nucleoporin 58 -0.0195071
GNAS GNAS complex locus -0.0191088
WSB1 WD repeat and SOCS box containing 1 -0.0190693
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0189895
S100A10 S100 calcium binding protein A10 -0.0187234
RLF rearranged L-myc fusion -0.0182876
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0181916
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0178994
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0178664
TPM4 tropomyosin 4 -0.0178498
TKT transketolase -0.0174955
WDR45B WD repeat domain 45B -0.0171447
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0170893
RPS8 ribosomal protein S8 -0.0170069
RPS23 ribosomal protein S23 -0.0168063
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0165109
RPS27 ribosomal protein S27 -0.0165103
PFN1 profilin 1 -0.0162092
RPL8 ribosomal protein L8 -0.016074
RPS19 ribosomal protein S19 -0.0160599
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0160035
BTG1 B-cell translocation gene 1, anti-proliferative -0.015871
RPL36 ribosomal protein L36 -0.0158679
TMSB4X thymosin beta 4, X-linked -0.0158311
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0157287
ANXA2 annexin A2 -0.0155912
IL1RAP interleukin 1 receptor accessory protein -0.0153841
RPL34 ribosomal protein L34 -0.0150025
COPB1 coatomer protein complex, subunit beta 1 -0.0149354
FAM162A family with sequence similarity 162, member A -0.0149305
PDE10A phosphodiesterase 10A -0.0149289
RPS16 ribosomal protein S16 -0.0143038
HLA-E major histocompatibility complex, class I, E -0.0142991
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0142491
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0140655
VDAC1 voltage-dependent anion channel 1 -0.0139198
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0138346
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0136552
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0133757
POSTN periostin, osteoblast specific factor -0.0133391
INSIG2 insulin induced gene 2 -0.0133126
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0132798
S100A11 S100 calcium binding protein A11 -0.0132489
NPEPPS aminopeptidase puromycin sensitive -0.0131887
S100A6 S100 calcium binding protein A6 -0.0131642
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0130583
LCORL ligand dependent nuclear receptor corepressor-like -0.0130511
KDM3A lysine (K)-specific demethylase 3A -0.0129592