Norepinephrine (hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Norepinephrine (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Norepinephrine (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) 0.13958
ANKRD28 ankyrin repeat domain 28 0.0869391
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0816812
SMAD3 SMAD family member 3 0.0735536
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0663523
STC1 stanniocalcin 1 0.0660823
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0612331
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0592341
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0589478
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0576848
ATXN1 ataxin 1 0.0553761
EXT1 exostosin glycosyltransferase 1 0.0536812
ASPH aspartate beta-hydroxylase 0.0514563
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0513877
ALCAM activated leukocyte cell adhesion molecule 0.0492143
FAM107B family with sequence similarity 107, member B 0.0491137
INTS6 integrator complex subunit 6 0.0475676
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.047432
RIGI RNA sensor RIG-I 0.0471978
ERRFI1 ERBB receptor feedback inhibitor 1 0.0467965
ZSWIM6 zinc finger, SWIM-type containing 6 0.0441999
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.043377
HMGA2 high mobility group AT-hook 2 0.041494
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0414517
TGFB1 transforming growth factor, beta 1 0.0412005
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0403831
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0396858
MACF1 microtubule-actin crosslinking factor 1 0.0393073
SP100 SP100 nuclear antigen 0.0389579
AADAC arylacetamide deacetylase 0.0377036
NAP1L1 nucleosome assembly protein 1-like 1 0.0376445
RPL4 ribosomal protein L4 0.0376245
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0369131
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0356926
ELL2 elongation factor, RNA polymerase II, 2 0.0348846
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0341049
ADM adrenomedullin 0.0336564
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0327571
NAV2 neuron navigator 2 0.0317811
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0317715
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0316904
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0307672
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0307133
HIPK2 homeodomain interacting protein kinase 2 0.0307088
B2M beta-2-microglobulin 0.0304325
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0302366
CALU calumenin 0.0301796
YBX3 Y box binding protein 3 0.0301457
IL6ST interleukin 6 signal transducer 0.0299736
SOD2 superoxide dismutase 2, mitochondrial 0.0297863
EZR ezrin 0.0292216
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0290537
MYO10 myosin X 0.0289872
PEAK1 pseudopodium-enriched atypical kinase 1 0.0286287
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0285177
TM4SF1 transmembrane 4 L six family member 1 0.028395
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0279807
MT2A metallothionein 2A 0.0279756
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0275481
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0270429
MAST4 microtubule associated serine/threonine kinase family member 4 0.0270049
RPL11 ribosomal protein L11 0.0268913
TFPI2 tissue factor pathway inhibitor 2 0.0266788
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0264849
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0259935
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0259555
IFIH1 interferon induced with helicase C domain 1 0.025934
EMP1 epithelial membrane protein 1 0.0258701
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0255005
JUN jun proto-oncogene 0.0253929
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0253518
SYAP1 synapse associated protein 1 0.0252406
IFI6 interferon, alpha-inducible protein 6 0.0251189
TPT1 tumor protein, translationally-controlled 1 0.0249218
IER3 immediate early response 3 0.0243354
LHFPL2 lipoma HMGIC fusion partner-like 2 0.024187
OSBPL8 oxysterol binding protein-like 8 0.0240791
RHCG Rh family, C glycoprotein 0.0239617
LDHA lactate dehydrogenase A 0.0238884
LOXL2 lysyl oxidase-like 2 0.0237791
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.023492
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0233155
IGF1R insulin-like growth factor 1 receptor 0.0228587
MBNL1 muscleblind-like splicing regulator 1 0.0225158
NAMPT nicotinamide phosphoribosyltransferase 0.0223262
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0222757
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0219452
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0216425
EREG epiregulin 0.0215774
ANXA1 annexin A1 0.0215453
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0211807
APP amyloid beta (A4) precursor protein 0.0211329
MCL1 myeloid cell leukemia 1 0.0211252
CTBP2 C-terminal binding protein 2 0.0209526
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0208667
ECE1 endothelin converting enzyme 1 0.020746
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0206089
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0205906
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0205648
ADAR adenosine deaminase, RNA-specific 0.0204163

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.166139
TMSB10 thymosin beta 10 -0.143653
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0892503
FTH1 ferritin, heavy polypeptide 1 -0.0768015
LOX lysyl oxidase -0.0700482
NRP1 neuropilin 1 -0.0660455
GOLGA4 golgin A4 -0.0641958
RUNX2 runt-related transcription factor 2 -0.0594042
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0520745
OSMR oncostatin M receptor -0.0503863
ZEB2 zinc finger E-box binding homeobox 2 -0.0482313
NPC1 Niemann-Pick disease, type C1 -0.0464678
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.04391
ARHGAP5 Rho GTPase activating protein 5 -0.0429098
PID1 phosphotyrosine interaction domain containing 1 -0.0424426
GLCCI1 glucocorticoid induced 1 -0.0418351
POTEF POTE ankyrin domain family, member F -0.041581
MRPS6 mitochondrial ribosomal protein S6 -0.0405445
FTL ferritin, light polypeptide -0.0387512
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.038653
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0385771
KMT2C lysine (K)-specific methyltransferase 2C -0.0370782
PDIA3 protein disulfide isomerase family A, member 3 -0.0370272
VEGFA vascular endothelial growth factor A -0.0361829
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0357353
MON2 MON2 homolog (S. cerevisiae) -0.0356239
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0354833
RAB27B RAB27B, member RAS oncogene family -0.0348551
MEF2A myocyte enhancer factor 2A -0.0332413
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0329145
S100A6 S100 calcium binding protein A6 -0.0323969
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0322254
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0320146
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0305089
LMAN1 lectin, mannose-binding, 1 -0.0302286
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0299627
EGR1 early growth response 1 -0.0299058
LOC112694756 uncharaterized LOC112694756 -0.0296362
ARID3B AT rich interactive domain 3B (BRIGHT-like) -0.0296118
DPYD dihydropyrimidine dehydrogenase -0.0296018
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.029578
TMEM131 transmembrane protein 131 -0.0283424
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0282642
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0279108
SRP54 signal recognition particle 54kDa -0.0275312
RNF145 ring finger protein 145 -0.0273692
ADD3 adducin 3 (gamma) -0.0271212
SREBF2 sterol regulatory element binding transcription factor 2 -0.0268503
GPC6 glypican 6 -0.0266488
RPL35A ribosomal protein L35a -0.0266279
HMGA1 high mobility group AT-hook 1 -0.0265632
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0263728
PRSS3 protease, serine, 3 -0.0260523
CLMP CXADR-like membrane protein -0.0260376
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0254561
PRRX1 paired related homeobox 1 -0.0252871
PFN1 profilin 1 -0.0250018
PTGIS prostaglandin I2 (prostacyclin) synthase -0.0247099
VRK2 vaccinia related kinase 2 -0.0247024
RAI14 retinoic acid induced 14 -0.0246281
MAP1B microtubule-associated protein 1B -0.0244323
LRRC8C leucine rich repeat containing 8 family, member C -0.0242033
NBAS neuroblastoma amplified sequence -0.0239996
AAK1 AP2 associated kinase 1 -0.0237607
PRRC2C proline-rich coiled-coil 2C -0.0236015
RB1CC1 RB1-inducible coiled-coil 1 -0.0230991
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.022986
RAP1B RAP1B, member of RAS oncogene family -0.0229146
PTEN phosphatase and tensin homolog -0.0226364
SETD5 SET domain containing 5 -0.0224675
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0222243
SDK1 sidekick cell adhesion molecule 1 -0.0221511
PLIN2 perilipin 2 -0.0220403
DLG1 discs, large homolog 1 (Drosophila) -0.0213759
ZFAND3 zinc finger, AN1-type domain 3 -0.0207508
PSD3 pleckstrin and Sec7 domain containing 3 -0.0205671
LIMCH1 LIM and calponin homology domains 1 -0.0205603
RNF149 ring finger protein 149 -0.0203913
UBE2H ubiquitin-conjugating enzyme E2H -0.0203898
RPLP1 ribosomal protein, large, P1 -0.0203075
ATP13A3 ATPase type 13A3 -0.0202712
BLZF1 basic leucine zipper nuclear factor 1 -0.020227
ZMYND8 zinc finger, MYND-type containing 8 -0.0201481
YBX1 Y box binding protein 1 -0.020125
ZNF804A zinc finger protein 804A -0.0200734
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0200445
EEF2 eukaryotic translation elongation factor 2 -0.0196753
CAB39 calcium binding protein 39 -0.0196456
GRB10 growth factor receptor-bound protein 10 -0.0194828
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.0193187
LRRC49 leucine rich repeat containing 49 -0.0191878
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0191482
AKAP12 A kinase (PRKA) anchor protein 12 -0.0188285
CIB1 calcium and integrin binding 1 (calmyrin) -0.0187902
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0187779
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0187198
GOSR1 golgi SNAP receptor complex member 1 -0.0187111
SMAD4 SMAD family member 4 -0.0184957
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.018464
SOS2 son of sevenless homolog 2 (Drosophila) -0.0183644