Norepinephrine (hydrochloride)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Norepinephrine (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Norepinephrine (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYO1E myosin IE 0.200085
LMO7 LIM domain 7 0.183792
SAMD4A sterile alpha motif domain containing 4A 0.17673
DSCAM Down syndrome cell adhesion molecule 0.168953
BACE2 beta-site APP-cleaving enzyme 2 0.0996589
AKAP12 A kinase (PRKA) anchor protein 12 0.0877769
LAMB3 laminin, beta 3 0.0864095
EXT1 exostosin glycosyltransferase 1 0.0861832
CEMIP cell migration inducing protein, hyaluronan binding 0.0833372
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0787166
KYNU kynureninase 0.0768544
VIM vimentin 0.0762419
RIGI RNA sensor RIG-I 0.0702247
COL6A3 collagen, type VI, alpha 3 0.0659155
TXNRD1 thioredoxin reductase 1 0.064731
TRIO trio Rho guanine nucleotide exchange factor 0.0634138
GRB10 growth factor receptor-bound protein 10 0.0624748
DOCK5 dedicator of cytokinesis 5 0.0614833
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0597592
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0597458
HMGA2 high mobility group AT-hook 2 0.0559141
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0555523
FN1 fibronectin 1 0.0547562
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0544661
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0524996
MPRIP myosin phosphatase Rho interacting protein 0.0514175
AHNAK AHNAK nucleoprotein 0.0513572
PCBP2 poly(rC) binding protein 2 0.0510757
MT2A metallothionein 2A 0.0500097
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0492622
TJP1 tight junction protein 1 0.0471017
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0456481
LAMC2 laminin, gamma 2 0.0439196
NCOR2 nuclear receptor corepressor 2 0.0437762
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0436481
TPT1 tumor protein, translationally-controlled 1 0.0432457
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.043228
RICTOR RPTOR independent companion of MTOR, complex 2 0.042915
NALF1 NALCN channel auxiliary factor 1 0.0426542
BIRC6 baculoviral IAP repeat containing 6 0.0424687
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0424118
HLA-B major histocompatibility complex, class I, B 0.0419882
ITPRID2 ITPR interacting domain containing 2 0.0416847
ASPH aspartate beta-hydroxylase 0.0414741
MED13L mediator complex subunit 13-like 0.0405219
BZW1 basic leucine zipper and W2 domains 1 0.0402532
EFNA5 ephrin-A5 0.0401036
SMAD3 SMAD family member 3 0.0400473
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0399066
PPARD peroxisome proliferator-activated receptor delta 0.0394949
RUNX1 runt-related transcription factor 1 0.0388196
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0385716
DTNA dystrobrevin, alpha 0.0376203
STC1 stanniocalcin 1 0.0374813
PLEC plectin 0.0373329
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0370708
MYO5B myosin VB 0.0361488
LIMCH1 LIM and calponin homology domains 1 0.0359095
PATJ PATJ crumbs cell polarity complex component 0.0356793
CXCL8 chemokine (C-X-C motif) ligand 8 0.0352479
HDLBP high density lipoprotein binding protein 0.0350833
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0347322
ZFC3H1 zinc finger, C3H1-type containing 0.0343314
IGF1R insulin-like growth factor 1 receptor 0.0342574
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0341944
TMOD3 tropomodulin 3 (ubiquitous) 0.0340301
TBC1D22A TBC1 domain family, member 22A 0.0337582
SH3KBP1 SH3-domain kinase binding protein 1 0.0334242
SDC4 syndecan 4 0.0333612
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0331673
NPEPPS aminopeptidase puromycin sensitive 0.0328977
ANXA2 annexin A2 0.0326421
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0324118
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0319579
ERN1 endoplasmic reticulum to nucleus signaling 1 0.03186
NCEH1 neutral cholesterol ester hydrolase 1 0.0317692
STRN3 striatin, calmodulin binding protein 3 0.0316575
SBF2 SET binding factor 2 0.0313686
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0310066
DLG1 discs, large homolog 1 (Drosophila) 0.0309316
ELL2 elongation factor, RNA polymerase II, 2 0.0309198
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0306121
RPS16 ribosomal protein S16 0.0303192
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0302267
NKD1 naked cuticle homolog 1 (Drosophila) 0.030088
RRBP1 ribosome binding protein 1 0.0300241
BCAR3 breast cancer anti-estrogen resistance 3 0.0297865
PARD3 par-3 family cell polarity regulator 0.0297666
ANXA11 annexin A11 0.0295895
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0294544
FNDC3B fibronectin type III domain containing 3B 0.0293441
RBM47 RNA binding motif protein 47 0.0293386
ABI1 abl-interactor 1 0.0293066
SEPTIN9 septin 9 0.0293049
KRT17 keratin 17, type I 0.0288608
SEC31A SEC31 homolog A (S. cerevisiae) 0.0283066
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0281614
PDLIM5 PDZ and LIM domain 5 0.028014
APP amyloid beta (A4) precursor protein 0.0278918
OGA O-GlcNAcase 0.0277197

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.0881382
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0526064
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0506339
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0499549
SLK STE20-like kinase -0.0457937
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0439127
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0417257
USP3 ubiquitin specific peptidase 3 -0.0417157
PHF3 PHD finger protein 3 -0.0413241
FDPS farnesyl diphosphate synthase -0.0388535
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0384221
NAV2 neuron navigator 2 -0.038356
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0380076
CDYL chromodomain protein, Y-like -0.0370892
NUP58 nucleoporin 58 -0.0370458
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0369714
PDIA3 protein disulfide isomerase family A, member 3 -0.0363341
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0354594
LCORL ligand dependent nuclear receptor corepressor-like -0.0353964
MBD5 methyl-CpG binding domain protein 5 -0.0349124
S100A8 S100 calcium binding protein A8 -0.0347941
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0345043
SSBP2 single-stranded DNA binding protein 2 -0.0344939
EGR1 early growth response 1 -0.0342751
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0335179
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0331188
CLDN7 claudin 7 -0.0328677
NDRG1 N-myc downstream regulated 1 -0.0328285
RIOK3 RIO kinase 3 -0.032735
MIS18BP1 MIS18 binding protein 1 -0.0327348
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0325489
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0322961
PRRC2B proline-rich coiled-coil 2B -0.032256
ARL5B ADP-ribosylation factor-like 5B -0.0319518
TMEM131 transmembrane protein 131 -0.0312466
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0310661
ITCH itchy E3 ubiquitin protein ligase -0.0309191
HMGXB3 HMG box domain containing 3 -0.0309032
EGFR epidermal growth factor receptor -0.0308989
ADAM17 ADAM metallopeptidase domain 17 -0.0308903
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0307781
H3-3B H3.3 histone B -0.030756
CENPF centromere protein F, 350/400kDa -0.0306121
FNBP1L formin binding protein 1-like -0.0304599
KDM3A lysine (K)-specific demethylase 3A -0.0303327
PRKCI protein kinase C, iota -0.0303318
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0300949
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0300301
GLG1 golgi glycoprotein 1 -0.0299886
RAB6A RAB6A, member RAS oncogene family -0.0299606
USP32 ubiquitin specific peptidase 32 -0.0299416
HOOK2 hook microtubule-tethering protein 2 -0.0298444
ANLN anillin, actin binding protein -0.0298115
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0296583
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0296294
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0296158
ATXN2 ataxin 2 -0.0288196
SLMAP sarcolemma associated protein -0.0286676
QKI QKI, KH domain containing, RNA binding -0.0286135
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0284494
TRA2A transformer 2 alpha homolog (Drosophila) -0.0283232
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0283091
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0282683
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0281715
ZNF292 zinc finger protein 292 -0.0281635
CPNE8 copine VIII -0.028106
SOS2 son of sevenless homolog 2 (Drosophila) -0.0277
LIFR leukemia inhibitory factor receptor alpha -0.0272893
SUCO SUN domain containing ossification factor -0.0272694
SLC38A1 solute carrier family 38, member 1 -0.0271379
OSBPL8 oxysterol binding protein-like 8 -0.0270257
RAB18 RAB18, member RAS oncogene family -0.0269756
AGTPBP1 ATP/GTP binding protein 1 -0.0269703
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0264023
MCU mitochondrial calcium uniporter -0.0263263
ANKRD10 ankyrin repeat domain 10 -0.026199
TM4SF1 transmembrane 4 L six family member 1 -0.0259584
TENT2 terminal nucleotidyltransferase 2 -0.0259118
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0259051
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0258775
S100A10 S100 calcium binding protein A10 -0.0256895
ITPKC inositol-trisphosphate 3-kinase C -0.0256688
TM9SF2 transmembrane 9 superfamily member 2 -0.0256622
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0254641
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0254519
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0253914
NOCT nocturnin -0.0253288
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.025229
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0252137
ECD ecdysoneless homolog (Drosophila) -0.0251724
ZBTB10 zinc finger and BTB domain containing 10 -0.0251351
PMM2 phosphomannomutase 2 -0.0248758
CFDP1 craniofacial development protein 1 -0.0248299
PLAU plasminogen activator, urokinase -0.0247468
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0246744
SP100 SP100 nuclear antigen -0.0245947
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.024552
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0245511
CHD9 chromodomain helicase DNA binding protein 9 -0.0245016
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0244204