| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Norepinephrine (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Norepinephrine (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.178974 |
| PDE10A | phosphodiesterase 10A | 0.142711 |
| DST | dystonin | 0.140686 |
| KYNU | kynureninase | 0.113952 |
| PDLIM5 | PDZ and LIM domain 5 | 0.112021 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.105065 |
| VCL | vinculin | 0.0962963 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0853843 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0852239 |
| GRAMD1B | GRAM domain containing 1B | 0.0835209 |
| ASPH | aspartate beta-hydroxylase | 0.0818642 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0807955 |
| GDA | guanine deaminase | 0.0769044 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0741061 |
| INTS6 | integrator complex subunit 6 | 0.074067 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0699886 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0648384 |
| SMAD2 | SMAD family member 2 | 0.0647432 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0646109 |
| FMNL2 | formin-like 2 | 0.0625741 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.062337 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0619114 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0594617 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0584686 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0560554 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0524492 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0516889 |
| PCBP2 | poly(rC) binding protein 2 | 0.0512952 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.049104 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0478856 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0470253 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0458356 |
| RAD51B | RAD51 paralog B | 0.0453093 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0452396 |
| PTEN | phosphatase and tensin homolog | 0.0443131 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0442726 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0423729 |
| ATXN1 | ataxin 1 | 0.042095 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0400949 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0392381 |
| POTEF | POTE ankyrin domain family, member F | 0.0378197 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0373045 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0371324 |
| BMP6 | bone morphogenetic protein 6 | 0.0355923 |
| MYOF | myoferlin | 0.0355497 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0347586 |
| DNER | delta/notch-like EGF repeat containing | 0.0340677 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0334808 |
| GPC6 | glypican 6 | 0.032192 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0308351 |
| RPL27 | ribosomal protein L27 | 0.0297535 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0296922 |
| PCBP3 | poly(rC) binding protein 3 | 0.0293545 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.029195 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0291901 |
| LDHA | lactate dehydrogenase A | 0.0290068 |
| AUTS2 | autism susceptibility candidate 2 | 0.0286274 |
| RPS12 | ribosomal protein S12 | 0.0285331 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0277208 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0275413 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0273492 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.027289 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0272295 |
| RPL4 | ribosomal protein L4 | 0.0272009 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0265664 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.026493 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0261885 |
| HDAC4 | histone deacetylase 4 | 0.0259161 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0258401 |
| FLNB | filamin B, beta | 0.0258069 |
| NRXN3 | neurexin 3 | 0.0254819 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0251351 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0246956 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.0246723 |
| MCL1 | myeloid cell leukemia 1 | 0.0245571 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0245439 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0245414 |
| GPHN | gephyrin | 0.0244774 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0244465 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0239724 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0238618 |
| WWOX | WW domain containing oxidoreductase | 0.0236147 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0232544 |
| HSPA8 | heat shock 70kDa protein 8 | 0.023011 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0227779 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0224679 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0224322 |
| RPL9 | ribosomal protein L9 | 0.0223614 |
| IRS2 | insulin receptor substrate 2 | 0.0223152 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0221447 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0220882 |
| ACTG1 | actin gamma 1 | 0.0218779 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0218328 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0218305 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0217569 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0217317 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0216055 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0214892 |
| RPS4X | ribosomal protein S4, X-linked | 0.0212647 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0212612 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.303269 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.121764 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.104599 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0932541 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0700034 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0692737 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0672493 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0644794 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0643807 |
| VIM | vimentin | -0.0643568 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.063232 |
| TMSB10 | thymosin beta 10 | -0.0623353 |
| PTMA | prothymosin, alpha | -0.0623041 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0484348 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0452231 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0435171 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.04193 |
| CANX | calnexin | -0.0411238 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0394993 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0386639 |
| OSMR | oncostatin M receptor | -0.0376729 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0376663 |
| CTSL | cathepsin L | -0.037071 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0370557 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0365932 |
| LAMB1 | laminin, beta 1 | -0.0349022 |
| S100A6 | S100 calcium binding protein A6 | -0.0340077 |
| STC1 | stanniocalcin 1 | -0.0327581 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0323433 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0315142 |
| NCKAP5 | NCK-associated protein 5 | -0.0311757 |
| RGS2 | regulator of G-protein signaling 2 | -0.0303387 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0292515 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0288002 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.028278 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0280189 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0279666 |
| KIAA0825 | KIAA0825 | -0.027158 |
| HLA-A | major histocompatibility complex, class I, A | -0.0269651 |
| HLA-B | major histocompatibility complex, class I, B | -0.0267366 |
| IL6 | interleukin 6 | -0.0266266 |
| FOXC1 | forkhead box C1 | -0.0254024 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0250388 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0249522 |
| INHBA | inhibin, beta A | -0.0247188 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.023885 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0237379 |
| TMSB4X | thymosin beta 4, X-linked | -0.0233648 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0232879 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0232098 |
| PTGR1 | prostaglandin reductase 1 | -0.0229198 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0228968 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0226804 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0226753 |
| RPL34 | ribosomal protein L34 | -0.0225147 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0223946 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0219579 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0217724 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.021531 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0214666 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0211018 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0208889 |
| UBC | ubiquitin C | -0.0207759 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0205806 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0205352 |
| B2M | beta-2-microglobulin | -0.0205081 |
| RPLP1 | ribosomal protein, large, P1 | -0.0204137 |
| TENM3 | teneurin transmembrane protein 3 | -0.0203125 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.020006 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0197811 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0197342 |
| EGR1 | early growth response 1 | -0.0196608 |
| WDR45B | WD repeat domain 45B | -0.0196331 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0188694 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.018704 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0186994 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0185444 |
| NEDD1 | neural precursor cell expressed, developmentally down-regulated 1 | -0.0185299 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0184626 |
| CRLF2 | cytokine receptor-like factor 2 | -0.0184415 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0183188 |
| GOLGA4 | golgin A4 | -0.0181954 |
| TPM4 | tropomyosin 4 | -0.018174 |
| SRGN | serglycin | -0.0181646 |
| PRSS23 | protease, serine, 23 | -0.0179236 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.017917 |
| FAM13A | family with sequence similarity 13, member A | -0.0177612 |
| GPRIN3 | GPRIN family member 3 | -0.0175033 |
| PHF21A | PHD finger protein 21A | -0.0174167 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0173053 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0170663 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0169832 |
| BMERB1 | bMERB domain containing 1 | -0.0169516 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0168553 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0163076 |
| PYGL | phosphorylase, glycogen, liver | -0.016236 |
| S100A10 | S100 calcium binding protein A10 | -0.0161422 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0161169 |
| CEP170 | centrosomal protein 170kDa | -0.015532 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0154453 |
