Norepinephrine (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Norepinephrine (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Norepinephrine (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.157682
TJP1 tight junction protein 1 0.147936
SOX6 SRY (sex determining region Y)-box 6 0.0963001
HDAC9 histone deacetylase 9 0.0940289
PKM pyruvate kinase, muscle 0.0886495
PDGFC platelet derived growth factor C 0.0786904
AHNAK AHNAK nucleoprotein 0.0755589
ZNF608 zinc finger protein 608 0.0703937
PDE4B phosphodiesterase 4B, cAMP-specific 0.0606558
ARL4C ADP-ribosylation factor-like 4C 0.058527
PRELID2 PRELI domain containing 2 0.0570428
PCBP2 poly(rC) binding protein 2 0.0561535
GLI2 GLI family zinc finger 2 0.0542186
MYO5C myosin VC 0.053565
LDHA lactate dehydrogenase A 0.0527505
NPAS2 neuronal PAS domain protein 2 0.0518146
DIAPH3 diaphanous-related formin 3 0.0490588
MACROD2 MACRO domain containing 2 0.0488744
HEG1 heart development protein with EGF-like domains 1 0.0486791
RAB27B RAB27B, member RAS oncogene family 0.0476246
GLI3 GLI family zinc finger 3 0.0466973
ANLN anillin, actin binding protein 0.0449699
PFN1 profilin 1 0.0416226
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0401961
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0401714
IRS1 insulin receptor substrate 1 0.0394802
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0392212
NCEH1 neutral cholesterol ester hydrolase 1 0.0380368
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0378178
DUSP4 dual specificity phosphatase 4 0.0366463
TXNRD1 thioredoxin reductase 1 0.0360704
LOC112694756 uncharaterized LOC112694756 0.0355383
TPI1 triosephosphate isomerase 1 0.0354286
VCL vinculin 0.03526
FAT1 FAT atypical cadherin 1 0.0348224
BMP2K BMP2 inducible kinase 0.0346662
ECT2 epithelial cell transforming 2 0.0344436
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0335441
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0334119
FER1L6 fer-1-like family member 6 0.0330562
ATP9B ATPase, class II, type 9B 0.0324903
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0323087
MT2A metallothionein 2A 0.0321963
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0319639
EZR ezrin 0.0317909
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0316901
TMEM65 transmembrane protein 65 0.0313984
GSE1 Gse1 coiled-coil protein 0.03132
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0309864
CCDC68 coiled-coil domain containing 68 0.0306756
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0302386
RRM2 ribonucleotide reductase M2 0.0300078
SFTPA2 surfactant protein A2 0.0299858
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0299502
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0295742
PYGB phosphorylase, glycogen; brain 0.0295045
SOX9 SRY (sex determining region Y)-box 9 0.0291193
SQSTM1 sequestosome 1 0.0291133
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0290052
RPL12 ribosomal protein L12 0.0289065
RACK1 receptor for activated C kinase 1 0.0288877
S100A4 S100 calcium binding protein A4 0.028756
ARID1A AT rich interactive domain 1A (SWI-like) 0.0287274
RPS8 ribosomal protein S8 0.0286966
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.0284784
YAP1 Yes-associated protein 1 0.0283363
RHOA ras homolog family member A 0.0282613
ZEB1 zinc finger E-box binding homeobox 1 0.0280197
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0278637
PTMS parathymosin 0.0278396
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0275703
ZNHIT6 zinc finger, HIT-type containing 6 0.0273497
IFI16 interferon, gamma-inducible protein 16 0.0271327
SMC4 structural maintenance of chromosomes 4 0.0269887
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.026983
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0267649
TRIM24 tripartite motif containing 24 0.0265822
PRPF38B pre-mRNA processing factor 38B 0.0264622
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0263021
RFC3 replication factor C (activator 1) 3, 38kDa 0.0260685
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0257895
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0255349
EEA1 early endosome antigen 1 0.0253832
SCFD1 sec1 family domain containing 1 0.0251366
CREB5 cAMP responsive element binding protein 5 0.0248861
LOXL3 lysyl oxidase-like 3 0.0248181
SLC38A2 solute carrier family 38, member 2 0.0247137
ENO1 enolase 1, (alpha) 0.024609
SNX14 sorting nexin 14 0.0243837
SET SET nuclear proto-oncogene 0.0241284
UNC5C unc-5 homolog C (C. elegans) 0.0240121
B2M beta-2-microglobulin 0.0239341
ZNF217 zinc finger protein 217 0.0237779
TRIOBP TRIO and F-actin binding protein 0.0235411
EML4 echinoderm microtubule associated protein like 4 0.0234415
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0233481
ZBTB38 zinc finger and BTB domain containing 38 0.0233405
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0231976
NCKAP1 NCK-associated protein 1 0.0231748
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0231631

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.170999
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.121378
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.114518
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.11147
CPED1 cadherin-like and PC-esterase domain containing 1 -0.10132
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0991836
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0611018
FOXP1 forkhead box P1 -0.05484
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0524129
RPS23 ribosomal protein S23 -0.0522627
FNDC3B fibronectin type III domain containing 3B -0.0511255
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0487752
ZMYND8 zinc finger, MYND-type containing 8 -0.0478351
SBF2 SET binding factor 2 -0.0467884
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0446564
KDM3A lysine (K)-specific demethylase 3A -0.0439986
WSB1 WD repeat and SOCS box containing 1 -0.0438136
RHBDD1 rhomboid domain containing 1 -0.0428736
RPS25 ribosomal protein S25 -0.0414535
HDLBP high density lipoprotein binding protein -0.0399514
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0396233
ZFAND3 zinc finger, AN1-type domain 3 -0.0393061
RPLP1 ribosomal protein, large, P1 -0.0390526
RLF rearranged L-myc fusion -0.0386813
RPS29 ribosomal protein S29 -0.0385046
RPL13A ribosomal protein L13a -0.0378298
RRBP1 ribosome binding protein 1 -0.0369778
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0357857
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0356643
COG5 component of oligomeric golgi complex 5 -0.0354324
RPS13 ribosomal protein S13 -0.035263
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0349522
EXOC6B exocyst complex component 6B -0.0348285
EPB41 erythrocyte membrane protein band 4.1 -0.0348116
NEBL nebulette -0.034282
RPL38 ribosomal protein L38 -0.0342565
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0340993
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0338946
SRPK2 SRSF protein kinase 2 -0.0337631
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0331635
KPNB1 karyopherin (importin) beta 1 -0.0330748
DLG1 discs, large homolog 1 (Drosophila) -0.0330595
TCF12 transcription factor 12 -0.0327245
HLA-B major histocompatibility complex, class I, B -0.0325198
NT5C2 5'-nucleotidase, cytosolic II -0.0322543
PHF14 PHD finger protein 14 -0.0320569
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0319945
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0316239
PTPRG protein tyrosine phosphatase, receptor type, G -0.0315566
TM9SF3 transmembrane 9 superfamily member 3 -0.031464
LARS1 leucyl-tRNA synthetase 1 -0.0311719
NFIA nuclear factor I/A -0.0309246
JMJD1C jumonji domain containing 1C -0.0305004
RPS3 ribosomal protein S3 -0.0303873
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.030239
RPL34 ribosomal protein L34 -0.0302193
CALR calreticulin -0.0300371
HMGB1 high mobility group box 1 -0.0299718
RBM39 RNA binding motif protein 39 -0.0298157
EIF5B eukaryotic translation initiation factor 5B -0.029736
ANKRD17 ankyrin repeat domain 17 -0.0297218
MBNL1 muscleblind-like splicing regulator 1 -0.0292058
ANKRD11 ankyrin repeat domain 11 -0.0291108
DENND1A DENN/MADD domain containing 1A -0.0288927
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0288027
MON2 MON2 homolog (S. cerevisiae) -0.0286052
LIMD1 LIM domains containing 1 -0.0283405
PGK1 phosphoglycerate kinase 1 -0.0281115
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0276498
TMEM41B transmembrane protein 41B -0.0275922
OSMR oncostatin M receptor -0.0273836
NOP56 NOP56 ribonucleoprotein -0.0272298
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0271778
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0269266
NBEA neurobeachin -0.0268356
CBFB core-binding factor, beta subunit -0.0266854
RBM8A RNA binding motif protein 8A -0.0266543
RPS24 ribosomal protein S24 -0.0264552
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0263071
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0261858
ELP2 elongator acetyltransferase complex subunit 2 -0.0260681
ZNF292 zinc finger protein 292 -0.0259292
RPL35A ribosomal protein L35a -0.0258254
ZNF609 zinc finger protein 609 -0.0258243
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0257402
RPS6 ribosomal protein S6 -0.0254596
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0253301
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0250768
IFITM3 interferon induced transmembrane protein 3 -0.0250548
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0248466
ACACA acetyl-CoA carboxylase alpha -0.0248208
SAFB2 scaffold attachment factor B2 -0.0247779
RPS15A ribosomal protein S15a -0.02454
ACBD6 acyl-CoA binding domain containing 6 -0.0245342
NGLY1 N-glycanase 1 -0.0244018
RPS15 ribosomal protein S15 -0.0243421
PWWP2A PWWP domain containing 2A -0.0242022
MSI2 musashi RNA-binding protein 2 -0.0240622
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0240098
EIF1 eukaryotic translation initiation factor 1 -0.0238884