Norepinephrine (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Norepinephrine (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Norepinephrine (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0979894
CEMIP cell migration inducing protein, hyaluronan binding 0.0728211
KMT2C lysine (K)-specific methyltransferase 2C 0.0665078
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0571195
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0555847
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0543641
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0538855
RPS3 ribosomal protein S3 0.0533479
SDK1 sidekick cell adhesion molecule 1 0.0532534
LPP LIM domain containing preferred translocation partner in lipoma 0.0514378
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0510374
ESYT2 extended synaptotagmin-like protein 2 0.0507757
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0498187
TPT1 tumor protein, translationally-controlled 1 0.0464534
SPAG9 sperm associated antigen 9 0.0462323
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0449856
NFIA nuclear factor I/A 0.0440423
RPS2 ribosomal protein S2 0.0437023
OSBPL10 oxysterol binding protein-like 10 0.0432824
EZR ezrin 0.0429462
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0425209
SAMD4A sterile alpha motif domain containing 4A 0.0423653
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0421835
PATJ PATJ crumbs cell polarity complex component 0.0421651
DSPP dentin sialophosphoprotein 0.0411843
TMF1 TATA element modulatory factor 1 0.0399926
RBM39 RNA binding motif protein 39 0.039822
RPS6 ribosomal protein S6 0.0389989
WWC1 WW and C2 domain containing 1 0.0381924
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0379122
KRT20 keratin 20, type I 0.0373045
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0366599
XPO1 exportin 1 0.0365581
FTL ferritin, light polypeptide 0.0364486
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0364324
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0362447
USP34 ubiquitin specific peptidase 34 0.0361635
RPL37A ribosomal protein L37a 0.0361425
FRMD5 FERM domain containing 5 0.0361011
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.036065
MACC1 metastasis associated in colon cancer 1 0.035429
MED13L mediator complex subunit 13-like 0.0350868
NKD1 naked cuticle homolog 1 (Drosophila) 0.0348052
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.034608
NIPBL Nipped-B homolog (Drosophila) 0.0343876
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0343507
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0342924
BBX bobby sox homolog (Drosophila) 0.0342494
GPHN gephyrin 0.0342276
EHBP1 EH domain binding protein 1 0.0335498
NEBL nebulette 0.0332121
KTN1 kinectin 1 (kinesin receptor) 0.0321532
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0320112
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.0317371
SBF2 SET binding factor 2 0.0317273
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0313801
AFDN afadin, adherens junction formation factor 0.0312423
TBC1D5 TBC1 domain family, member 5 0.0308256
MSI2 musashi RNA-binding protein 2 0.0307239
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0303779
CLTC clathrin, heavy chain (Hc) 0.0303673
GOLGA4 golgin A4 0.0303481
STK4 serine/threonine kinase 4 0.0302601
PCLO piccolo presynaptic cytomatrix protein 0.0302462
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0301849
KDM2A lysine (K)-specific demethylase 2A 0.0301641
EPCAM epithelial cell adhesion molecule 0.0301174
PKP4 plakophilin 4 0.0300464
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0299896
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0297437
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0293564
PRRC2C proline-rich coiled-coil 2C 0.0292661
SETD5 SET domain containing 5 0.0292574
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0289372
THOC2 THO complex 2 0.028832
TRIO trio Rho guanine nucleotide exchange factor 0.0286951
NKTR natural killer cell triggering receptor 0.0286069
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0285501
GCC2 GRIP and coiled-coil domain containing 2 0.0284154
AKAP13 A kinase (PRKA) anchor protein 13 0.0283959
CKAP5 cytoskeleton associated protein 5 0.028309
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.028244
PARD3B par-3 family cell polarity regulator beta 0.0273528
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0269183
RPS12 ribosomal protein S12 0.0268545
HSPA8 heat shock 70kDa protein 8 0.0266655
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0266642
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0264621
CLIP2 CAP-GLY domain containing linker protein 2 0.0263855
OXR1 oxidation resistance 1 0.0263587
FAT1 FAT atypical cadherin 1 0.0263528
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0263314
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0263161
SETD2 SET domain containing 2 0.0262247
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0261954
XRN2 5'-3' exoribonuclease 2 0.0257458
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0255783
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0255021
ZNRF3 zinc and ring finger 3 0.0254322
MUC13 mucin 13, cell surface associated 0.0252328

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.200562
TMSB10 thymosin beta 10 -0.170325
FTH1 ferritin, heavy polypeptide 1 -0.157306
PTMA prothymosin, alpha -0.136612
KRT8 keratin 8, type II -0.123563
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114236
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0942434
ACTN4 actinin, alpha 4 -0.0689933
RPS27A ribosomal protein S27a -0.0683829
VMP1 vacuole membrane protein 1 -0.0682682
ANXA2 annexin A2 -0.0675354
LOC112694756 uncharaterized LOC112694756 -0.0632666
EGR1 early growth response 1 -0.063105
EEF2 eukaryotic translation elongation factor 2 -0.0625266
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0598326
RPL23 ribosomal protein L23 -0.0582209
POTEF POTE ankyrin domain family, member F -0.0576425
PKM pyruvate kinase, muscle -0.0519681
KRT18 keratin 18, type I -0.0513679
GNAS GNAS complex locus -0.0467538
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0452972
S100A6 S100 calcium binding protein A6 -0.0421362
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0413955
PDIA4 protein disulfide isomerase family A, member 4 -0.0411315
PDIA3 protein disulfide isomerase family A, member 3 -0.0398344
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0397235
CCND1 cyclin D1 -0.0395679
S100A10 S100 calcium binding protein A10 -0.0384835
PCBP2 poly(rC) binding protein 2 -0.0380825
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0374561
H1-0 H1.0 linker histone -0.0350398
AHNAK AHNAK nucleoprotein -0.0346706
PDIA6 protein disulfide isomerase family A, member 6 -0.0343415
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0337441
EEF1G eukaryotic translation elongation factor 1 gamma -0.0335829
RAD21 RAD21 homolog (S. pombe) -0.0333021
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0331551
CST3 cystatin C -0.032299
TOP1 topoisomerase (DNA) I -0.0322899
PERP PERP, TP53 apoptosis effector -0.0316804
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0313763
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0302967
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0301904
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0299828
GSTP1 glutathione S-transferase pi 1 -0.0297113
TMEM123 transmembrane protein 123 -0.0291041
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0289913
HLA-A major histocompatibility complex, class I, A -0.0288193
JUP junction plakoglobin -0.0286386
SPDYA speedy/RINGO cell cycle regulator family member A -0.0284332
JUN jun proto-oncogene -0.0283128
TXNIP thioredoxin interacting protein -0.0279431
FLNA filamin A, alpha -0.0275494
P4HB prolyl 4-hydroxylase, beta polypeptide -0.02702
CALR calreticulin -0.0262639
ITGB4 integrin, beta 4 -0.0262006
ARHGAP12 Rho GTPase activating protein 12 -0.0255966
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0254402
RPL8 ribosomal protein L8 -0.0241173
HMGB1 high mobility group box 1 -0.0237718
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0233182
TFG TRK-fused gene -0.0229653
EHF ets homologous factor -0.0224843
SNX9 sorting nexin 9 -0.022319
EMP1 epithelial membrane protein 1 -0.0221656
INSIG1 insulin induced gene 1 -0.022004
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0218038
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -0.0213816
UBE2D1 ubiquitin-conjugating enzyme E2D 1 -0.0212316
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0210062
CTSD cathepsin D -0.0209923
RHEB Ras homolog enriched in brain -0.0208829
GARS1 glycyl-tRNA synthetase 1 -0.020648
RPS11 ribosomal protein S11 -0.0205198
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0202814
GLS2 glutaminase 2 (liver, mitochondrial) -0.0194901
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0194015
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0189453
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0188962
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0187436
AMOTL2 angiomotin like 2 -0.0186143
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0184863
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0180965
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0177076
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0176116
MYO18A myosin XVIIIA -0.017444
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0174343
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.017399
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0172962
RHOA ras homolog family member A -0.0172344
CCDC6 coiled-coil domain containing 6 -0.0171139
COG5 component of oligomeric golgi complex 5 -0.0170867
ZNF217 zinc finger protein 217 -0.0170398
MATR3 matrin 3 -0.0168893
RAD23B RAD23 homolog B (S. cerevisiae) -0.0168348
VEGFA vascular endothelial growth factor A -0.0167253
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0166635
CAPN1 calpain 1, (mu/I) large subunit -0.0165985
MEF2A myocyte enhancer factor 2A -0.0164884
OXSR1 oxidative stress responsive 1 -0.0164825