Norepinephrine (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Norepinephrine (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Norepinephrine (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.14193
VCL vinculin 0.141641
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.124071
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.121371
NAV2 neuron navigator 2 0.111205
WWOX WW domain containing oxidoreductase 0.108013
SYT1 synaptotagmin I 0.0901897
EZR ezrin 0.0865241
INTS6 integrator complex subunit 6 0.0820572
LMO7 LIM domain 7 0.0788124
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.075619
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0723675
TNS3 tensin 3 0.0688047
CDK6 cyclin-dependent kinase 6 0.0645496
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.061675
DST dystonin 0.0616102
SMAD3 SMAD family member 3 0.0580102
SPATA13 spermatogenesis associated 13 0.0579518
AHNAK AHNAK nucleoprotein 0.0573829
ASPH aspartate beta-hydroxylase 0.0573533
ITPRID2 ITPR interacting domain containing 2 0.0564283
MSI2 musashi RNA-binding protein 2 0.0564245
LDHA lactate dehydrogenase A 0.0543731
CDH13 cadherin 13 0.0540251
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0535619
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0532332
PDE4D phosphodiesterase 4D, cAMP-specific 0.0522396
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0507736
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0506174
RAD51B RAD51 paralog B 0.0495527
TRIO trio Rho guanine nucleotide exchange factor 0.0493159
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0491794
SMYD3 SET and MYND domain containing 3 0.0481471
FRMD5 FERM domain containing 5 0.0478495
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.047845
EXOC4 exocyst complex component 4 0.0471811
MACF1 microtubule-actin crosslinking factor 1 0.0463437
YAP1 Yes-associated protein 1 0.0459263
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0445299
HDAC4 histone deacetylase 4 0.0444646
PDLIM5 PDZ and LIM domain 5 0.0442999
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0438503
ACTN1 actinin, alpha 1 0.0434577
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0432895
GMDS GDP-mannose 4,6-dehydratase 0.0432254
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0426797
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0424679
LRMDA leucine rich melanocyte differentiation associated 0.0413069
TMEM163 transmembrane protein 163 0.0409802
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0407345
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0404641
ANXA2 annexin A2 0.040445
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0397047
RCOR1 REST corepressor 1 0.0394997
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0392343
KLF12 Kruppel-like factor 12 0.0390871
ZSWIM6 zinc finger, SWIM-type containing 6 0.0387794
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0385321
USP9X ubiquitin specific peptidase 9, X-linked 0.0382789
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0382047
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0379915
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0379523
IPO7 importin 7 0.0377553
DOCK5 dedicator of cytokinesis 5 0.0377098
COBL cordon-bleu WH2 repeat protein 0.0376186
EHBP1 EH domain binding protein 1 0.0371947
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0371902
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0367866
ACTG1 actin gamma 1 0.0367405
IGF1R insulin-like growth factor 1 receptor 0.0366465
FAT1 FAT atypical cadherin 1 0.0366051
RABGAP1L RAB GTPase activating protein 1-like 0.0363579
WNK1 WNK lysine deficient protein kinase 1 0.0361854
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.036111
CCND1 cyclin D1 0.0360979
DLG1 discs, large homolog 1 (Drosophila) 0.0359716
SLC38A2 solute carrier family 38, member 2 0.0353094
DIAPH2 diaphanous-related formin 2 0.0350203
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0348111
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0343935
ITGA6 integrin, alpha 6 0.0343536
SEPTIN9 septin 9 0.0340136
FMNL2 formin-like 2 0.0339067
SERINC5 serine incorporator 5 0.0335691
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0334857
SPIDR scaffolding protein involved in DNA repair 0.0331956
APP amyloid beta (A4) precursor protein 0.0330778
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0330559
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0330165
LPP LIM domain containing preferred translocation partner in lipoma 0.0328069
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0327016
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0326332
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0325985
BICD1 bicaudal D homolog 1 (Drosophila) 0.0325387
DOCK9 dedicator of cytokinesis 9 0.0325082
MYO1D myosin ID 0.0324844
GPHN gephyrin 0.0323546
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0321762
RAB10 RAB10, member RAS oncogene family 0.0320759
ADGRL2 adhesion G protein-coupled receptor L2 0.0320084

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.0788374
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0707971
RPL35A ribosomal protein L35a -0.0657331
TMSB10 thymosin beta 10 -0.0589564
RPS19 ribosomal protein S19 -0.0470733
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0455446
RPL23 ribosomal protein L23 -0.0431873
RPLP1 ribosomal protein, large, P1 -0.040622
RPLP2 ribosomal protein, large, P2 -0.0369844
HMGA1 high mobility group AT-hook 1 -0.035573
RPS21 ribosomal protein S21 -0.0297241
MT2A metallothionein 2A -0.0295842
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0288366
RPS12 ribosomal protein S12 -0.0286886
RPL37A ribosomal protein L37a -0.028161
RPS13 ribosomal protein S13 -0.0280664
RPL26 ribosomal protein L26 -0.0280178
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0278128
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0277219
ESYT2 extended synaptotagmin-like protein 2 -0.0271023
FTL ferritin, light polypeptide -0.0265295
EEF2 eukaryotic translation elongation factor 2 -0.0262233
ZNF292 zinc finger protein 292 -0.025918
EGR1 early growth response 1 -0.0258766
RPS3 ribosomal protein S3 -0.0256182
RPL35 ribosomal protein L35 -0.0254079
RPS14 ribosomal protein S14 -0.0246555
GOLGA4 golgin A4 -0.0245867
RPS27 ribosomal protein S27 -0.0238968
PTMA prothymosin, alpha -0.0238029
RPL31 ribosomal protein L31 -0.0227167
RPS17 ribosomal protein S17 -0.0222721
NDRG1 N-myc downstream regulated 1 -0.022249
RPL12 ribosomal protein L12 -0.0221698
CD46 CD46 molecule, complement regulatory protein -0.0217032
RPL36 ribosomal protein L36 -0.021668
EEF1G eukaryotic translation elongation factor 1 gamma -0.0214434
RPS8 ribosomal protein S8 -0.0212993
RPS2 ribosomal protein S2 -0.0203581
ITGB4 integrin, beta 4 -0.0202093
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0197037
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0193218
RPL28 ribosomal protein L28 -0.0188121
PFN1 profilin 1 -0.0187936
WDFY2 WD repeat and FYVE domain containing 2 -0.0186544
RPL18 ribosomal protein L18 -0.018242
RPL34 ribosomal protein L34 -0.0181432
RPL36A ribosomal protein L36a -0.0177016
FTH1 ferritin, heavy polypeptide 1 -0.01672
RPL11 ribosomal protein L11 -0.0165202
RPS25 ribosomal protein S25 -0.0164631
RPS29 ribosomal protein S29 -0.016249
AVL9 AVL9 homolog (S. cerevisiase) -0.016161
AKAP9 A kinase (PRKA) anchor protein 9 -0.0161085
RPL9 ribosomal protein L9 -0.0160383
BHLHE40 basic helix-loop-helix family, member e40 -0.0158678
RPS23 ribosomal protein S23 -0.015818
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0157378
MON2 MON2 homolog (S. cerevisiae) -0.0154142
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0154134
LOC112694756 uncharaterized LOC112694756 -0.0152571
ABHD2 abhydrolase domain containing 2 -0.0151621
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0151545
COPA coatomer protein complex, subunit alpha -0.0150498
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0145278
AKAP12 A kinase (PRKA) anchor protein 12 -0.0144008
ACBD3 acyl-CoA binding domain containing 3 -0.0141873
MSN moesin -0.0138879
FKBP9 FK506 binding protein 9, 63 kDa -0.0137451
RPL21 ribosomal protein L21 -0.0137394
RPL37 ribosomal protein L37 -0.0137181
TXNIP thioredoxin interacting protein -0.0136708
PDIA3 protein disulfide isomerase family A, member 3 -0.0134478
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0134209
RPL8 ribosomal protein L8 -0.0132161
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0129875
GARS1 glycyl-tRNA synthetase 1 -0.012968
CIRSR corepressor of RBPJ and splicing regulator -0.0129447
FOSL1 FOS-like antigen 1 -0.0128884
SRP54 signal recognition particle 54kDa -0.0128313
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0127964
MXD1 MAX dimerization protein 1 -0.0125766
CDK19 cyclin-dependent kinase 19 -0.012552
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0125098
PGM3 phosphoglucomutase 3 -0.0124091
RPS15 ribosomal protein S15 -0.0122827
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -0.0121907
TMEM39A transmembrane protein 39A -0.0120706
PLAG1 pleiomorphic adenoma gene 1 -0.0119251
PKM pyruvate kinase, muscle -0.011783
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0117829
TMF1 TATA element modulatory factor 1 -0.0117542
LAMA5 laminin, alpha 5 -0.0116647
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0116161
RLIM ring finger protein, LIM domain interacting -0.0114739
ARF4 ADP-ribosylation factor 4 -0.0113993
RPS5 ribosomal protein S5 -0.0112999
S100A9 S100 calcium binding protein A9 -0.0112964
WASF2 WAS protein family, member 2 -0.0110479
ETNK1 ethanolamine kinase 1 -0.0109143