Notch signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. (Gene Ontology, GO_0007219)
External Link https://www.kegg.jp/entry/hsa04330
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Genes

62 proteins participating in the Notch signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ATXN1 ataxin 1
ATXN1L ataxin 1-like
CIRSR corepressor of RBPJ and splicing regulator
CREBBP CREB binding protein
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
DLL1 delta-like 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
DLL4 delta-like 4 (Drosophila)
DTX1 deltex 1, E3 ubiquitin ligase
DTX2 deltex 2, E3 ubiquitin ligase
DTX3 deltex 3, E3 ubiquitin ligase
DTX3L deltex 3 like, E3 ubiquitin ligase
DTX4 deltex 4, E3 ubiquitin ligase
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EP300 E1A binding protein p300
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HES5 hes family bHLH transcription factor 5
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HEYL hes-related family bHLH transcription factor with YRPW motif-like
ITCH itchy E3 ubiquitin protein ligase
JAG1 jagged 1
JAG2 jagged 2
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LOC102724023 ES1 protein homolog, mitochondrial
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MAML3 mastermind-like 3 (Drosophila)
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
NCOR2 nuclear receptor corepressor 2
NCSTN nicastrin
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NOTCH4 notch 4
NRARP NOTCH-regulated ankyrin repeat protein
NUMB numb homolog (Drosophila)
NUMBL numb homolog (Drosophila)-like
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PTCRA pre T-cell antigen receptor alpha
RBM15 RNA binding motif protein 15
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SNW1 SNW domain containing 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE2 transducin-like enhancer of split 2
TLE3 transducin-like enhancer of split 3
TLE4 transducin-like enhancer of split 4
TLE6 transducin-like enhancer of split 6
TLE7 TLE family member 7