OA-10-PB21_0.01uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.01uM, Tiospirone, alpha1-Adrenoceptor Antagonists targeting ADRA1B, HTR1E, HTR1F (Novartis, 55752)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/55752
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Genes

152 genes differentially expressed following the OA-10-PB21_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 1.06723
RPLP1 ribosomal protein, large, P1 0.835904
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 0.771905
RPS21 ribosomal protein S21 0.757071
RPLP2 ribosomal protein, large, P2 0.684876
TMSB10 thymosin beta 10 0.678713
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.626977
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.618307
RPS16 ribosomal protein S16 0.608926
TMEM258 transmembrane protein 258 0.608926
COX5B cytochrome c oxidase subunit Vb 0.608926
TMEM256 transmembrane protein 256 0.580037
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) 0.571009
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.554897
RPS23 ribosomal protein S23 0.554897
RPL39 ribosomal protein L39 0.537355
RPS27A ribosomal protein S27a 0.530264
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.530264
RPS17 ribosomal protein S17 0.52992
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.526295
RPS29 ribosomal protein S29 0.506859
S100A2 S100 calcium binding protein A2 0.506859
RPL35 ribosomal protein L35 0.493978
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.485483
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.476179
ATP5MG ATP synthase membrane subunit g 0.476179
SSR4 signal sequence receptor, delta 0.473705
RPL27 ribosomal protein L27 0.473434
DDTL D-dopachrome tautomerase-like 0.468848
RPS10 ribosomal protein S10 0.459483
C5ORF46 chromosome 5 open reading frame 46 0.446362
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.426793
RPL34 ribosomal protein L34 0.423641
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 0.423641
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 0.417755
ROMO1 reactive oxygen species modulator 1 0.415337
S100A6 S100 calcium binding protein A6 0.411675
NDUFA4 NDUFA4, mitochondrial complex associated 0.409521
RSL24D1 ribosomal L24 domain containing 1 0.408988
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 0.404089
RPL26 ribosomal protein L26 0.384828
RPL41 ribosomal protein L41 0.383409
PRDX1 peroxiredoxin 1 0.380388
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.375064
RPL27A ribosomal protein L27a 0.373678
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.368486
ATOX1 antioxidant 1 copper chaperone 0.360805
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.359075
RPS27 ribosomal protein S27 0.352686
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.352537
CHURC1-FNTB CHURC1-FNTB readthrough 0.351619
GSTP1 glutathione S-transferase pi 1 0.349722
PFDN5 prefoldin subunit 5 0.322892
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.311046
RPS3A ribosomal protein S3A 0.311046
RPS19 ribosomal protein S19 0.310804
RPS9 ribosomal protein S9 0.303742
ZNF90 zinc finger protein 90 0.303742
ATP5F1E ATP synthase F1 subunit epsilon 0.302098
RPL31 ribosomal protein L31 0.301605
UBL5 ubiquitin-like 5 0.299276
MYL12B myosin, light chain 12B, regulatory 0.298766
RPS13 ribosomal protein S13 0.298766
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.298766
ATP5MC1 ATP synthase membrane subunit c locus 1 0.296731
ZNHIT1 zinc finger, HIT-type containing 1 0.290192
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa 0.290192
C12ORF57 chromosome 12 open reading frame 57 0.287626
BEST1 bestrophin 1 0.277942
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.275549
RPS3 ribosomal protein S3 0.267678
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.267678
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.265632
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.252971
COX14 COX14 cytochrome c oxidase assembly factor 0.247013
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 0.24335
UBC ubiquitin C 0.240517
RPL19 ribosomal protein L19 0.239537
ATP5PO ATP synthase peripheral stalk subunit OSCP 0.238627
RNF181 ring finger protein 181 0.233142
RPS27L ribosomal protein S27-like 0.23185
HDGF hepatoma-derived growth factor 0.230199
SNRPG small nuclear ribonucleoprotein polypeptide G 0.230142
ATP5MF ATP synthase membrane subunit f 0.228565
RPL18 ribosomal protein L18 0.227296
RPS20 ribosomal protein S20 0.227296
RPS18 ribosomal protein S18 0.222754
TRAPPC2L trafficking protein particle complex 2-like 0.22057
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 0.217778
LGALS1 lectin, galactoside-binding, soluble, 1 0.215806
RPL9 ribosomal protein L9 0.215806
TALDO1 transaldolase 1 0.214608
RPL32 ribosomal protein L32 0.210606
DPY30 dpy-30 homolog (C. elegans) 0.209799
RPL37 ribosomal protein L37 0.209799
ANXA2 annexin A2 0.209412
RPL12 ribosomal protein L12 0.20935
SF3B5 splicing factor 3b, subunit 5, 10kDa 0.209331
BTN3A3 butyrophilin, subfamily 3, member A3 0.209331
UQCRH ubiquinol-cytochrome c reductase hinge protein 0.209331
HAPLN1 hyaluronan and proteoglycan link protein 1 0.208793
RBM8A RNA binding motif protein 8A 0.208176
DYNLL1 dynein, light chain, LC8-type 1 0.20596
RPS15 ribosomal protein S15 0.204162
BRIX1 BRX1, biogenesis of ribosomes 0.204162
PHPT1 phosphohistidine phosphatase 1 0.203268
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.203029

decreased expression

Symbol Name Standardized Value
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -1.32484
PPDPF pancreatic progenitor cell differentiation and proliferation factor -1.30148
LRRC37B leucine rich repeat containing 37B -1.2338
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.919711
RPL11 ribosomal protein L11 -0.897045
RXYLT1 ribitol xylosyltransferase 1 -0.730838
APP amyloid beta (A4) precursor protein -0.624642
C12ORF43 chromosome 12 open reading frame 43 -0.594407
ZNF740 zinc finger protein 740 -0.499277
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.443481
PRR11 proline rich 11 -0.436364
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.426805
PKM pyruvate kinase, muscle -0.417755
KPNB1 karyopherin (importin) beta 1 -0.398044
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.394469
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.392527
FHL2 four and a half LIM domains 2 -0.38089
CDC20 cell division cycle 20 -0.376099
TLN1 talin 1 -0.360246
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.324498
DTNB dystrobrevin, beta -0.322856
RRP1B ribosomal RNA processing 1B -0.311046
KRT81 keratin 81, type II -0.303742
DDB2 damage-specific DNA binding protein 2, 48kDa -0.302098
TARDBP TAR DNA binding protein -0.301605
PRPF19 pre-mRNA processing factor 19 -0.293753
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.287172
EIF3B eukaryotic translation initiation factor 3, subunit B -0.275125
MRPS27 mitochondrial ribosomal protein S27 -0.268189
FLII flightless I homolog (Drosophila) -0.247013
PHGDH phosphoglycerate dehydrogenase -0.246491
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.24093
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 -0.235971
RBFA ribosome binding factor A (putative) -0.235402
PPME1 protein phosphatase methylesterase 1 -0.229829
CLUH clustered mitochondria (cluA/CLU1) homolog -0.223752
MCM3 minichromosome maintenance complex component 3 -0.223492
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -0.216546
MRPS2 mitochondrial ribosomal protein S2 -0.211992
WTAP Wilms tumor 1 associated protein -0.210808
HARBI1 harbinger transposase derived 1 -0.210665
ANKFY1 ankyrin repeat and FYVE domain containing 1 -0.204862
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.204862
PEA15 phosphoprotein enriched in astrocytes 15 -0.204862
EIF3C eukaryotic translation initiation factor 3, subunit C -0.202102