OA-10-PB21_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, Tiospirone, alpha1-Adrenoceptor Antagonists targeting ADRA1B, HTR1E, HTR1F (Novartis, 55752)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/55752
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Genes

58 genes differentially expressed following the OA-10-PB21_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
RPS29 ribosomal protein S29 0.696145
RPLP1 ribosomal protein, large, P1 0.673481
RPS21 ribosomal protein S21 0.478372
RSL24D1 ribosomal L24 domain containing 1 0.477775
RPS12 ribosomal protein S12 0.382091
SF3B5 splicing factor 3b, subunit 5, 10kDa 0.349253
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.349253
RPS27A ribosomal protein S27a 0.342004
BEST1 bestrophin 1 0.335985
MT1E metallothionein 1E 0.304333
HINT1 histidine triad nucleotide binding protein 1 0.271881
RPS17 ribosomal protein S17 0.26969
RPL27A ribosomal protein L27a 0.26573
RPS10 ribosomal protein S10 0.245766
S100A10 S100 calcium binding protein A10 0.241663
UQCRH ubiquinol-cytochrome c reductase hinge protein 0.241663
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 0.231081
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.223648
RPL9 ribosomal protein L9 0.221117
TMSB10 thymosin beta 10 0.213431
RPL27 ribosomal protein L27 0.213431
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.210446
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.210446

decreased expression

Symbol Name Standardized Value
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -2.0101
RPL11 ribosomal protein L11 -1.67817
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -1.49525
LRRC37B leucine rich repeat containing 37B -1.47023
PPDPF pancreatic progenitor cell differentiation and proliferation factor -1.2382
RBPJ recombination signal binding protein for immunoglobulin kappa J region -1.17953
RPS14 ribosomal protein S14 -0.597371
RXYLT1 ribitol xylosyltransferase 1 -0.590089
UBAP2 ubiquitin associated protein 2 -0.588973
TOR1B torsin family 1, member B (torsin B) -0.581953
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.531967
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.490037
ZNF740 zinc finger protein 740 -0.440504
KRT81 keratin 81, type II -0.412856
STYXL1 serine/threonine/tyrosine interacting-like 1 -0.406696
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -0.398661
SAV1 salvador family WW domain containing protein 1 -0.372648
CDC20 cell division cycle 20 -0.358974
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.332529
CNN2 calponin 2 -0.320796
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.29682
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.281527
PRR11 proline rich 11 -0.272617
GOLGA4 golgin A4 -0.256898
LPCAT3 lysophosphatidylcholine acyltransferase 3 -0.251106
IFNGR1 interferon gamma receptor 1 -0.250288
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.229768
PARVA parvin, alpha -0.229379
ARFRP1 ADP-ribosylation factor related protein 1 -0.224616
HMX2 H6 family homeobox 2 -0.223648
FHL2 four and a half LIM domains 2 -0.221117
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -0.214422
DCAF7 DDB1 and CUL4 associated factor 7 -0.213766
FRMD8 FERM domain containing 8 -0.213431
FRMD5 FERM domain containing 5 -0.202762