OA-10-PB21_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, Tiospirone, alpha1-Adrenoceptor Antagonists targeting ADRA1B, HTR1E, HTR1F (Novartis, 55752)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/55752
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Genes

150 genes differentially expressed following the OA-10-PB21_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.28547
SH3D19 SH3 domain containing 19 2.04611
ERG28 ergosterol biosynthesis 28 homolog 2.02168
DHCR7 7-dehydrocholesterol reductase 1.87108
FDPS farnesyl diphosphate synthase 1.40831
MVD mevalonate (diphospho) decarboxylase 1.31384
TMEM97 transmembrane protein 97 1.1652
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.11908
RPLP1 ribosomal protein, large, P1 1.0086
TNNI3 troponin I type 3 (cardiac) 0.990639
SOAT2 sterol O-acyltransferase 2 0.98841
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.953957
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.855581
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.847167
GUK1 guanylate kinase 1 0.805716
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.709148
ACSS2 acyl-CoA synthetase short-chain family member 2 0.706799
MSMO1 methylsterol monooxygenase 1 0.696376
NPC2 Niemann-Pick disease, type C2 0.643053
RPL18A ribosomal protein L18a 0.621448
QPRT quinolinate phosphoribosyltransferase 0.619561
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.573729
FADS2 fatty acid desaturase 2 0.554797
RPS3 ribosomal protein S3 0.543314
TMEM258 transmembrane protein 258 0.53023
ITGB5 integrin, beta 5 0.508974
TMSB10 thymosin beta 10 0.506599
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.471231
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.466147
RPS29 ribosomal protein S29 0.466147
RPL37A ribosomal protein L37a 0.462276
RPS27 ribosomal protein S27 0.461678
RPL18 ribosomal protein L18 0.439426
RPL34 ribosomal protein L34 0.427183
ZNHIT1 zinc finger, HIT-type containing 1 0.426628
RPS19 ribosomal protein S19 0.4226
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.420549
RPS9 ribosomal protein S9 0.413083
RPLP2 ribosomal protein, large, P2 0.408051
RPL38 ribosomal protein L38 0.408051
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.403615
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.394738
CD9 CD9 molecule 0.393044
GABARAP GABA(A) receptor-associated protein 0.389347
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 0.386122
A1BG alpha-1-B glycoprotein 0.374018
SERF2 small EDRK-rich factor 2 0.366302
RPS10 ribosomal protein S10 0.365964
PFDN5 prefoldin subunit 5 0.360471
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.360471
RPS15 ribosomal protein S15 0.352875
SSR4 signal sequence receptor, delta 0.343667
RPS21 ribosomal protein S21 0.338628
FASN fatty acid synthase 0.330563
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.330045
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.327231
CRYAB crystallin, alpha B 0.31984
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.319552
RPS16 ribosomal protein S16 0.302261
RPS7 ribosomal protein S7 0.297034
ELOVL5 ELOVL fatty acid elongase 5 0.295618
MYL12B myosin, light chain 12B, regulatory 0.29238
TIMP1 TIMP metallopeptidase inhibitor 1 0.276928
RPL35A ribosomal protein L35a 0.273042
LMBR1 limb development membrane protein 1 0.27062
CCN2 cellular communication network factor 2 0.267936
RPL41 ribosomal protein L41 0.266522
RPL39 ribosomal protein L39 0.263914
RPL13A ribosomal protein L13a 0.263618
MT2A metallothionein 2A 0.259396
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.258573
RNASEK ribonuclease, RNase K 0.255016
UBC ubiquitin C 0.254417
SLC39A13 solute carrier family 39 (zinc transporter), member 13 0.247353
RPL28 ribosomal protein L28 0.241847
KRT34 keratin 34, type I 0.240187
RABAC1 Rab acceptor 1 (prenylated) 0.238061
C12ORF57 chromosome 12 open reading frame 57 0.236177
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 0.233585
RPL27 ribosomal protein L27 0.231227
RPS18 ribosomal protein S18 0.230813
RPS17 ribosomal protein S17 0.230813
ATOX1 antioxidant 1 copper chaperone 0.230813
C19ORF33 chromosome 19 open reading frame 33 0.229109
ROMO1 reactive oxygen species modulator 1 0.229109
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.227395
MVP major vault protein 0.225676
TSEN34 TSEN34 tRNA splicing endonuclease subunit 0.222792
ALDOC aldolase C, fructose-bisphosphate 0.222193
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 0.22202
MUSK muscle, skeletal, receptor tyrosine kinase 0.215916
HMGA1 high mobility group AT-hook 1 0.214484
MVK mevalonate kinase 0.207864
RPS12 ribosomal protein S12 0.20546
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) 0.203547
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.202566
ZNF90 zinc finger protein 90 0.202566
TRIB3 tribbles pseudokinase 3 0.201842

decreased expression

Symbol Name Standardized Value
LRRC37B leucine rich repeat containing 37B -2.21259
RXYLT1 ribitol xylosyltransferase 1 -1.73826
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -1.70861
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -1.52355
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.982842
ZNF740 zinc finger protein 740 -0.953957
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.901491
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.699817
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.564539
CDC20 cell division cycle 20 -0.527156
RPL11 ribosomal protein L11 -0.473764
TARDBP TAR DNA binding protein -0.472186
PFDN1 prefoldin subunit 1 -0.409027
RRM2 ribonucleotide reductase M2 -0.397804
KRT81 keratin 81, type II -0.381107
EDN2 endothelin 2 -0.365951
KRT80 keratin 80, type II -0.350305
UBAP2 ubiquitin associated protein 2 -0.338126
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -0.321616
MAGED1 melanoma antigen family D1 -0.311802
NCOA3 nuclear receptor coactivator 3 -0.298416
FAM168B family with sequence similarity 168, member B -0.286749
LAMB3 laminin, beta 3 -0.286592
SMTN smoothelin -0.283407
FLOT1 flotillin 1 -0.27791
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -0.273052
INTS4 integrator complex subunit 4 -0.272819
IFNGR1 interferon gamma receptor 1 -0.261982
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -0.261182
SF3A1 splicing factor 3a, subunit 1, 120kDa -0.259845
CDKN3 cyclin-dependent kinase inhibitor 3 -0.258057
ZNF263 zinc finger protein 263 -0.258057
KIF5B kinesin family member 5B -0.250157
CERS6 ceramide synthase 6 -0.249504
SAV1 salvador family WW domain containing protein 1 -0.244676
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) -0.238954
MARCKSL1 MARCKS-like 1 -0.238061
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -0.236177
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.233955
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -0.231589
RPL4 ribosomal protein L4 -0.231519
PRELID1 PRELI domain containing 1 -0.231248
NOP56 NOP56 ribonucleoprotein -0.230509
PARD3 par-3 family cell polarity regulator -0.229774
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.2261
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -0.225974
TOR1B torsin family 1, member B (torsin B) -0.220689
IQCC IQ motif containing C -0.219443
MEPCE methylphosphate capping enzyme -0.217349
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.214554
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -0.209851
DAND5 DAN domain family member 5, BMP antagonist -0.209027