OA-74-FH10_0.01uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.01uM, Losartan Carboxaldehyde, Cyclooxygenase-2 Inhibitors;Angiotensin AT1 Antagonists targeting AGTR1, PTGS2 (Novartis, 9802264)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9802264
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Genes

64 genes differentially expressed following the OA-74-FH10_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.463218
TMEM258 transmembrane protein 258 0.463218
LGALS1 lectin, galactoside-binding, soluble, 1 0.463218
RPL35 ribosomal protein L35 0.463218
RPS9 ribosomal protein S9 0.463218
RPL30 ribosomal protein L30 0.431396
RPL10A ribosomal protein L10a 0.405027
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.404864
RPS14 ribosomal protein S14 0.399506
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.399506
RPLP2 ribosomal protein, large, P2 0.399506
PHPT1 phosphohistidine phosphatase 1 0.381631
RPS16 ribosomal protein S16 0.381631
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.381631
RPS5 ribosomal protein S5 0.379177
RPL5 ribosomal protein L5 0.379177
UXT ubiquitously-expressed, prefoldin-like chaperone 0.373622
RNF181 ring finger protein 181 0.369758
RPL18A ribosomal protein L18a 0.369465
RPS19 ribosomal protein S19 0.369465
UBC ubiquitin C 0.369465
NENF neudesin neurotrophic factor 0.355955
RPS3 ribosomal protein S3 0.332349
BLVRB biliverdin reductase B 0.332349
S100A6 S100 calcium binding protein A6 0.332349
RPL28 ribosomal protein L28 0.328716
C12ORF57 chromosome 12 open reading frame 57 0.324746
S100A2 S100 calcium binding protein A2 0.322659
MRPL41 mitochondrial ribosomal protein L41 0.312344
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.298683
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.29168
SIVA1 SIVA1, apoptosis-inducing factor 0.289201
PFDN5 prefoldin subunit 5 0.284553
ZNF90 zinc finger protein 90 0.277265
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.275905
NNMT nicotinamide N-methyltransferase 0.275905
SERF2 small EDRK-rich factor 2 0.275905
EIF3K eukaryotic translation initiation factor 3, subunit K 0.269577
PITX1 paired-like homeodomain 1 0.261254
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.257439
SMDT1 single-pass membrane protein with aspartate-rich tail 1 0.257439
SSR4 signal sequence receptor, delta 0.249329
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.248619
CUTA cutA divalent cation tolerance homolog (E. coli) 0.247851
NME1-NME2 NME1-NME2 readthrough 0.24492
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.24492
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.24492
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.24492
RPL8 ribosomal protein L8 0.243689
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 0.242406
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.242406
GUK1 guanylate kinase 1 0.237993
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 0.235748
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 0.226007
MZT2B mitotic spindle organizing protein 2B 0.223119
CENPM centromere protein M 0.223119
RPS10 ribosomal protein S10 0.223119
C19ORF33 chromosome 19 open reading frame 33 0.223119
PRDX5 peroxiredoxin 5 0.222492
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.218934
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.216922
URGCP-MRPS24 URGCP-MRPS24 readthrough 0.214784
DGCR6L DiGeorge syndrome critical region gene 6-like 0.200089

decreased expression

Symbol Name Standardized Value
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.269507