| Dataset | Pathway Commons Protein-Protein Interactions |
| Category | physical interactions |
| Type | interacting protein |
| Description | 2'-5'-oligoadenylate synthetase 2, 69/71kDa|This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4939) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/4939 |
| Similar Terms | |
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3 interacting proteins for OAS2 from the Pathway Commons Protein-Protein Interactions dataset.
