OB-46-IM27_0.01uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.01uM, N-[2-[[3-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]ethyl]acetamide (Novartis, 24986839)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/24986839
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Genes

24 genes differentially expressed following the OB-46-IM27_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
BLVRB biliverdin reductase B 3.07959
FBXW5 F-box and WD repeat domain containing 5 0.870578
LGALS1 lectin, galactoside-binding, soluble, 1 0.630991
MVP major vault protein 0.547752
RPS15 ribosomal protein S15 0.469442
HSPB1 heat shock 27kDa protein 1 0.455662
RPL37A ribosomal protein L37a 0.355282
TIMP1 TIMP metallopeptidase inhibitor 1 0.344414
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.329768
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 0.329768
PHPT1 phosphohistidine phosphatase 1 0.302414
S100A9 S100 calcium binding protein A9 0.295779
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.254719
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.245057
MZT2A mitotic spindle organizing protein 2A 0.239204
LMNB2 lamin B2 0.239204
ROMO1 reactive oxygen species modulator 1 0.239204
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.235907
COX5B cytochrome c oxidase subunit Vb 0.235824
CDC20 cell division cycle 20 0.217976
HYAL2 hyaluronoglucosaminidase 2 0.213299
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.202322

decreased expression

Symbol Name Standardized Value
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.258162
BEST1 bestrophin 1 -0.21443