OB-46-IM27_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, N-[2-[[3-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]ethyl]acetamide (Novartis, 24986839)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/24986839
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Genes

130 genes differentially expressed following the OB-46-IM27_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
BLVRB biliverdin reductase B 2.22176
ZNF593 zinc finger protein 593 0.664139
KRTAP2-3 keratin associated protein 2-3 0.655351
CCDC85B coiled-coil domain containing 85B 0.475487
CDPF1 cysteine-rich, DPF motif domain containing 1 0.455095
S100A6 S100 calcium binding protein A6 0.433784
FBXW5 F-box and WD repeat domain containing 5 0.42369
PDLIM4 PDZ and LIM domain 4 0.419638
PMEPA1 prostate transmembrane protein, androgen induced 1 0.414304
HRNR hornerin 0.414015
CCND2 cyclin D2 0.407928
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.397616
TIMP1 TIMP metallopeptidase inhibitor 1 0.391355
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.387773
MFSD3 major facilitator superfamily domain containing 3 0.387095
YDJC YdjC homolog (bacterial) 0.378722
KRT18 keratin 18, type I 0.375407
HSPA8 heat shock 70kDa protein 8 0.364518
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 0.336824
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.329385
RNF145 ring finger protein 145 0.307875
TMEM147 transmembrane protein 147 0.284763
SLC25A39 solute carrier family 25, member 39 0.281953
HSPA1A heat shock 70kDa protein 1A 0.279153
MVP major vault protein 0.279153
CDC20 cell division cycle 20 0.2651
CUEDC2 CUE domain containing 2 0.25087
MPG N-methylpurine-DNA glycosylase 0.25087
SH3BP4 SH3-domain binding protein 4 0.25087
TRAPPC6A trafficking protein particle complex 6A 0.247027
SNU13 small nuclear ribonucleoprotein 13 0.243287
JMJD4 jumonji domain containing 4 0.239276
ZC3H12D zinc finger CCCH-type containing 12D 0.237293
TMEM134 transmembrane protein 134 0.237131
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.237064
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.227191
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 0.216938
SYCE1L synaptonemal complex central element protein 1-like 0.211296
UPP1 uridine phosphorylase 1 0.211296
CAPN15 calpain 15 0.211258
UCK1 uridine-cytidine kinase 1 0.209744
RPS2 ribosomal protein S2 0.205606
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.200921
STK16 serine/threonine kinase 16 0.200495
MRPL36 mitochondrial ribosomal protein L36 0.200053

decreased expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.4191
ACTG1 actin gamma 1 -1.78654
TPM1 tropomyosin 1 (alpha) -1.73991
MAGED1 melanoma antigen family D1 -1.51813
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -1.26656
POTEF POTE ankyrin domain family, member F -1.22016
CALR calreticulin -1.05423
STMN1 stathmin 1 -0.988412
PMF1-BGLAP PMF1-BGLAP readthrough -0.970525
TUBA1B tubulin, alpha 1b -0.940367
COL1A1 collagen, type I, alpha 1 -0.94022
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.841462
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.760493
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -0.745041
GNAS GNAS complex locus -0.698282
MCM7 minichromosome maintenance complex component 7 -0.681834
TNNT1 troponin T type 1 (skeletal, slow) -0.681834
AP1M2 adaptor-related protein complex 1, mu 2 subunit -0.607023
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 -0.583119
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -0.583058
MSMO1 methylsterol monooxygenase 1 -0.578628
MVD mevalonate (diphospho) decarboxylase -0.577317
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -0.575048
ERG28 ergosterol biosynthesis 28 homolog -0.535197
EIF3C eukaryotic translation initiation factor 3, subunit C -0.524001
CTSL cathepsin L -0.514664
SH3D19 SH3 domain containing 19 -0.494561
CLU clusterin -0.475487
DHCR7 7-dehydrocholesterol reductase -0.468695
FADS2 fatty acid desaturase 2 -0.468177
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.459614
CNN1 calponin 1, basic, smooth muscle -0.436517
HSPB1 heat shock 27kDa protein 1 -0.436029
QPRT quinolinate phosphoribosyltransferase -0.429806
FUS FUS RNA binding protein -0.414304
SFTPA2 surfactant protein A2 -0.414015
PRDX1 peroxiredoxin 1 -0.402118
TAGLN transgelin -0.394861
MFAP2 microfibrillar-associated protein 2 -0.388668
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -0.385766
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.364518
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.364518
C12ORF57 chromosome 12 open reading frame 57 -0.357879
TMSB4X thymosin beta 4, X-linked -0.341336
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.340666
MDK midkine (neurite growth-promoting factor 2) -0.33992
TPI1 triosephosphate isomerase 1 -0.331603
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.33066
ADI1 acireductone dioxygenase 1 -0.329385
SPAG7 sperm associated antigen 7 -0.327348
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.322938
SMIM29 small integral membrane protein 29 -0.316858
SNRPA small nuclear ribonucleoprotein polypeptide A -0.313019
SREBF2 sterol regulatory element binding transcription factor 2 -0.310042
TK1 thymidine kinase 1, soluble -0.303044
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.286798
RNF44 ring finger protein 44 -0.281953
AIF1L allograft inflammatory factor 1-like -0.281541
MAGED2 melanoma antigen family D2 -0.279153
TKT transketolase -0.277131
CRYBG2 crystallin beta-gamma domain containing 2 -0.277005
NUP62 nucleoporin 62kDa -0.274379
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.273287
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.271298
RRM2 ribonucleotide reductase M2 -0.266701
PTMA prothymosin, alpha -0.266701
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.258747
GRN granulin -0.258747
PHF19 PHD finger protein 19 -0.257163
KLHL18 kelch-like family member 18 -0.243665
PCOLCE procollagen C-endopeptidase enhancer -0.243665
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.243287
PUF60 poly-U binding splicing factor 60KDa -0.240817
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.237293
CSRP1 cysteine and glycine-rich protein 1 -0.237293
HDLBP high density lipoprotein binding protein -0.224826
JUND jun D proto-oncogene -0.223429
TMSB10 thymosin beta 10 -0.222893
CHD8 chromodomain helicase DNA binding protein 8 -0.222893
RPS29 ribosomal protein S29 -0.221482
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.220667
UBE2C ubiquitin-conjugating enzyme E2C -0.219987
RPL22L1 ribosomal protein L22-like 1 -0.217221
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -0.211613
UBB ubiquitin B -0.206748