OB-65-AI50_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, Rgfp966, HDAC3 active-site competitive inhibitor;HDAC3 targeting HDAC3 (Novartis, 56650312)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/56650312
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Genes

15 genes differentially expressed following the OB-65-AI50_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
CSE1L CSE1 chromosome segregation 1-like (yeast) 2.07603
PPDPF pancreatic progenitor cell differentiation and proliferation factor 1.25228
RPL31 ribosomal protein L31 0.711546
RHOG ras homolog family member G 0.672199
FBXW5 F-box and WD repeat domain containing 5 0.335163
TNNT1 troponin T type 1 (skeletal, slow) 0.273084
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 0.26919

decreased expression

Symbol Name Standardized Value
FKBP1C FK506 binding protein 1C -0.317829
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.26919
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.26919
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.26919
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.246742
KLHL12 kelch-like family member 12 -0.234903
AGTPBP1 ATP/GTP binding protein 1 -0.221257
COG7 component of oligomeric golgi complex 7 -0.210402