OB-65-AI50_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, Rgfp966, HDAC3 active-site competitive inhibitor;HDAC3 targeting HDAC3 (Novartis, 56650312)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/56650312
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Genes

571 genes differentially expressed following the OB-65-AI50_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
UPP1 uridine phosphorylase 1 3.94589
HMOX1 heme oxygenase 1 3.66069
TRIB3 tribbles pseudokinase 3 3.53755
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.51244
FTH1 ferritin, heavy polypeptide 1 3.31485
FTL ferritin, light polypeptide 3.26482
DDIT4 DNA-damage-inducible transcript 4 3.20169
SQSTM1 sequestosome 1 2.65018
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.54261
ATF4 activating transcription factor 4 2.39649
KRT34 keratin 34, type I 2.35721
GDF15 growth differentiation factor 15 2.13546
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.09186
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.05222
TXNRD1 thioredoxin reductase 1 2.02972
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 1.90923
TRIM16 tripartite motif containing 16 1.59205
BLVRB biliverdin reductase B 1.5612
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.38109
MYDGF myeloid-derived growth factor 1.33802
PIKFYVE phosphoinositide kinase, FYVE finger containing 1.31267
SLC48A1 solute carrier family 48 (heme transporter), member 1 1.30661
RPS18 ribosomal protein S18 1.29458
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 1.20363
PHGDH phosphoglycerate dehydrogenase 1.19922
IER3 immediate early response 3 1.16368
CLU clusterin 1.12365
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.1138
MFGE8 milk fat globule-EGF factor 8 protein 1.05583
MRPL13 mitochondrial ribosomal protein L13 1.03178
DDIT3 DNA-damage-inducible transcript 3 1.03108
IL21R interleukin 21 receptor 1.01645
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 1.00345
RPL15 ribosomal protein L15 0.987832
RPL18A ribosomal protein L18a 0.944901
MT2A metallothionein 2A 0.940777
SYTL3 synaptotagmin-like 3 0.919374
CSRP1 cysteine and glycine-rich protein 1 0.902882
PRR20G proline rich 20G 0.890912
PYCR1 pyrroline-5-carboxylate reductase 1 0.880942
PLPP2 phospholipid phosphatase 2 0.863409
FRG2C FSHD region gene 2 family, member C 0.863409
TTC9B tetratricopeptide repeat domain 9B 0.854972
RPL8 ribosomal protein L8 0.845292
AKR1C2 aldo-keto reductase family 1, member C2 0.832635
RACK1 receptor for activated C kinase 1 0.825367
TIMP1 TIMP metallopeptidase inhibitor 1 0.809076
NUPR1 nuclear protein, transcriptional regulator, 1 0.805051
SYNGR2 synaptogyrin 2 0.797561
STC2 stanniocalcin 2 0.782717
ANKRD11 ankyrin repeat domain 11 0.781966
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.744577
UBC ubiquitin C 0.742548
JUND jun D proto-oncogene 0.7334
LHFPL3 lipoma HMGIC fusion partner-like 3 0.724143
FKBP9 FK506 binding protein 9, 63 kDa 0.723079
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.71329
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.713281
TMEM205 transmembrane protein 205 0.698247
SDF2L1 stromal cell-derived factor 2-like 1 0.697
RPL18 ribosomal protein L18 0.684561
CPLX2 complexin 2 0.637629
RABAC1 Rab acceptor 1 (prenylated) 0.63607
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.635021
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.623044
ITGB5 integrin, beta 5 0.620611
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.617327
NQO1 NAD(P)H dehydrogenase, quinone 1 0.598745
NDRG1 N-myc downstream regulated 1 0.597499
IL1A interleukin 1, alpha 0.593281
OBSL1 obscurin-like 1 0.586687
CAMKV CaM kinase-like vesicle-associated 0.581638
RPL28 ribosomal protein L28 0.579343
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.576861
ETV4 ets variant 4 0.57411
ETV5 ets variant 5 0.57411
BEST1 bestrophin 1 0.571885
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.55776
SRXN1 sulfiredoxin 1 0.551532
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 0.549378
SH2D4B SH2 domain containing 4B 0.547593
RPL36 ribosomal protein L36 0.546606
ASS1 argininosuccinate synthase 1 0.540691
CYSTM1 cysteine-rich transmembrane module containing 1 0.535287
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.53514
PLAUR plasminogen activator, urokinase receptor 0.522211
XBP1 X-box binding protein 1 0.51962
TEX19 testis expressed 19 0.518734
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.517246
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 0.517234
FGF21 fibroblast growth factor 21 0.506982
P4HB prolyl 4-hydroxylase, beta polypeptide 0.500936
PABPC1L poly(A) binding protein, cytoplasmic 1-like 0.499467
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.498814
PRRX2 paired related homeobox 2 0.496281
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 0.490617
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.479215
SFTPA2 surfactant protein A2 0.475055
TBC1D10C TBC1 domain family, member 10C 0.474508
SPANXB1 SPANX family, member B1 0.470875
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.464608
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.462344
SLPI secretory leukocyte peptidase inhibitor 0.462189
ZFAND3 zinc finger, AN1-type domain 3 0.459759
MT1X metallothionein 1X 0.459391
VGF VGF nerve growth factor inducible 0.457761
KLC3 kinesin light chain 3 0.456633
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.453963
FADS2 fatty acid desaturase 2 0.447097
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 0.445688
UBB ubiquitin B 0.444772
CXXC1 CXXC finger protein 1 0.442819
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.442404
ZDHHC4 zinc finger, DHHC-type containing 4 0.440362
SESN2 sestrin 2 0.439964
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 0.438996
LY6E lymphocyte antigen 6 complex, locus E 0.432349
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.432195
BUD31 BUD31 homolog (S. cerevisiae) 0.429933
OAZ1 ornithine decarboxylase antizyme 1 0.429933
OSGIN1 oxidative stress induced growth inhibitor 1 0.42744
PPY pancreatic polypeptide 0.426342
CDPF1 cysteine-rich, DPF motif domain containing 1 0.418964
LONP1 lon peptidase 1, mitochondrial 0.417601
HAX1 HCLS1 associated protein X-1 0.417094
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.415494
ASMTL acetylserotonin O-methyltransferase-like 0.415389
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.404584
TKT transketolase 0.403991
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.402143
PHC2 polyhomeotic homolog 2 (Drosophila) 0.401792
HBA2 hemoglobin, alpha 2 0.394229
HLA-E major histocompatibility complex, class I, E 0.386336
CCDC85B coiled-coil domain containing 85B 0.379739
HM13 histocompatibility (minor) 13 0.373761
RPS15 ribosomal protein S15 0.372842
PLK3 polo-like kinase 3 0.366606
SDC4 syndecan 4 0.36614
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.364992
TMSB10 thymosin beta 10 0.363091
EPAS1 endothelial PAS domain protein 1 0.36259
HMGA1 high mobility group AT-hook 1 0.360733
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.35951
SERP1 stress-associated endoplasmic reticulum protein 1 0.357385
LARP6 La ribonucleoprotein domain family, member 6 0.354153
TAGLN3 transgelin 3 0.354111
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 0.352503
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.349947
PRDX5 peroxiredoxin 5 0.349534
RAB39B RAB39B, member RAS oncogene family 0.345721
OLAH oleoyl-ACP hydrolase 0.342893
NGFR nerve growth factor receptor 0.339176
EIF1 eukaryotic translation initiation factor 1 0.339082
MT1E metallothionein 1E 0.337716
AUP1 ancient ubiquitous protein 1 0.335463
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J 0.335097
GTPBP2 GTP binding protein 2 0.327418
RPS2 ribosomal protein S2 0.324243
ZNF593 zinc finger protein 593 0.319613
CKB creatine kinase, brain 0.315347
DHDH dihydrodiol dehydrogenase (dimeric) 0.308037
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.308037
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.307419
OSMR oncostatin M receptor 0.307399
PARD6A par-6 family cell polarity regulator alpha 0.305917
METAP2 methionyl aminopeptidase 2 0.305799
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 0.304293
PRNP prion protein 0.304155
SYT5 synaptotagmin V 0.302014
LSR lipolysis stimulated lipoprotein receptor 0.300953
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 0.298491
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 0.297504
OSBP2 oxysterol binding protein 2 0.296145
SELENOM selenoprotein M 0.295872
THEM6 thioesterase superfamily member 6 0.29571
FGFR1 fibroblast growth factor receptor 1 0.292065
KRTAP2-3 keratin associated protein 2-3 0.29157
SYP synaptophysin 0.29124
RPS10 ribosomal protein S10 0.289457
SCG5 secretogranin V 0.289207
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 0.287566
TRAF1 TNF receptor-associated factor 1 0.285868
AGTRAP angiotensin II receptor-associated protein 0.280129
AREG amphiregulin 0.27878
INHBE inhibin, beta E 0.277794
UROS uroporphyrinogen III synthase 0.277794
A1BG alpha-1-B glycoprotein 0.277182
NECTIN2 nectin cell adhesion molecule 2 0.276827
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.275171
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.275171
GPAT3 glycerol-3-phosphate acyltransferase 3 0.274259
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.272366
S100P S100 calcium binding protein P 0.271768
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 0.269803
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 0.26913
BEX2 brain expressed X-linked 2 0.26805
IL24 interleukin 24 0.267452
GOLT1A golgi transport 1A 0.266221
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.265935
RPL31 ribosomal protein L31 0.265062
ISG20 interferon stimulated exonuclease gene 20kDa 0.264443
CD300A CD300a molecule 0.263787
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 0.263332
RHOG ras homolog family member G 0.262582
PLIN3 perilipin 3 0.262436
SURF4 surfeit 4 0.261995
GMPPA GDP-mannose pyrophosphorylase A 0.260551
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.258598
CNFN cornifelin 0.257414
CARHSP1 calcium regulated heat stable protein 1, 24kDa 0.256874
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.256874
TMEM151A transmembrane protein 151A 0.25623
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.254561
TMEM54 transmembrane protein 54 0.252557
TSPAN4 tetraspanin 4 0.252323
UBL4A ubiquitin-like 4A 0.250837
SPNS1 spinster homolog 1 (Drosophila) 0.250591
RHBDD2 rhomboid domain containing 2 0.249562
RBM11 RNA binding motif protein 11 0.24833
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.246936
RHEBL1 Ras homolog enriched in brain like 1 0.24667
IER2 immediate early response 2 0.246043
TSC22D3 TSC22 domain family, member 3 0.244282
KIFC2 kinesin family member C2 0.243285
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 0.241487
RIMKLA ribosomal modification protein rimK-like family member A 0.240655
MSTO1 misato 1, mitochondrial distribution and morphology regulator 0.237497
YBX2 Y box binding protein 2 0.237497
HPCAL4 hippocalcin like 4 0.237497
CARD19 caspase recruitment domain family member 19 0.237497
NFE2L1 nuclear factor, erythroid 2-like 1 0.235672
HES7 hes family bHLH transcription factor 7 0.235378
SH2B3 SH2B adaptor protein 3 0.234157
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 0.233888
FBXW5 F-box and WD repeat domain containing 5 0.233559
UBL7 ubiquitin-like 7 0.2318
RPL4 ribosomal protein L4 0.2318
MILR1 mast cell immunoglobulin-like receptor 1 0.231513
FOSL1 FOS-like antigen 1 0.231038
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.229638
CST3 cystatin C 0.229192
RPN1 ribophorin I 0.228826
GPX4 glutathione peroxidase 4 0.22326
RHOF ras homolog family member F (in filopodia) 0.222546
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.22229
OVGP1 oviductal glycoprotein 1, 120kDa 0.222078
AKR1C3 aldo-keto reductase family 1, member C3 0.221718
ENO3 enolase 3 (beta, muscle) 0.22139
NLRP4 NLR family, pyrin domain containing 4 0.219807
LAMA1 laminin, alpha 1 0.21914
NQO2 NAD(P)H dehydrogenase, quinone 2 0.217518
TRIM25 tripartite motif containing 25 0.217387
PADI4 peptidyl arginine deiminase, type IV 0.217387
RPS19 ribosomal protein S19 0.216569
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 0.21576
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 0.21507
EGFL7 EGF-like-domain, multiple 7 0.213919
FAM107A family with sequence similarity 107, member A 0.211694
HLA-B major histocompatibility complex, class I, B 0.211575
PTPRH protein tyrosine phosphatase, receptor type, H 0.210807
TNNT1 troponin T type 1 (skeletal, slow) 0.209455
TMEM59L transmembrane protein 59-like 0.208089
SPRR2D small proline-rich protein 2D 0.20733
SPX spexin hormone 0.207197
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.205962
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.204399
ARL2 ADP-ribosylation factor-like 2 0.204211
CHPF chondroitin polymerizing factor 0.20357
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 0.203329
AKR1C1 aldo-keto reductase family 1, member C1 0.202626
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.202594
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.202559
PLAT plasminogen activator, tissue 0.202198
INSL4 insulin-like 4 (placenta) 0.201515
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.201497
CIAO2B cytosolic iron-sulfur assembly component 2B 0.201449
CADM3 cell adhesion molecule 3 0.201387
RRAS related RAS viral (r-ras) oncogene homolog 0.20088
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.200801
SERINC2 serine incorporator 2 0.200623
RPS3 ribosomal protein S3 0.200439
PRAF2 PRA1 domain family, member 2 0.200268
HKDC1 hexokinase domain containing 1 0.200071

decreased expression

Symbol Name Standardized Value
CLPTM1L CLPTM1-like -4.14057
TPM1 tropomyosin 1 (alpha) -3.88002
PCLO piccolo presynaptic cytomatrix protein -3.47801
EDN2 endothelin 2 -3.21137
HDGF hepatoma-derived growth factor -2.89303
AP1M2 adaptor-related protein complex 1, mu 2 subunit -2.00925
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 -1.93353
MAGED1 melanoma antigen family D1 -1.77759
BIRC5 baculoviral IAP repeat containing 5 -1.76508
SUMO2 small ubiquitin-like modifier 2 -1.74335
NF2 neurofibromin 2 (merlin) -1.59509
DTYMK deoxythymidylate kinase (thymidylate kinase) -1.57652
BMP4 bone morphogenetic protein 4 -1.57226
STMN1 stathmin 1 -1.49205
ZXDB zinc finger, X-linked, duplicated B -1.48993
HAPLN1 hyaluronan and proteoglycan link protein 1 -1.46826
KRT75 keratin 75, type II -1.44577
TRIP6 thyroid hormone receptor interactor 6 -1.386
CXCL14 chemokine (C-X-C motif) ligand 14 -1.38109
TUBB tubulin, beta class I -1.3111
GUK1 guanylate kinase 1 -1.29458
CENPX centromere protein X -1.27662
GLS2 glutaminase 2 (liver, mitochondrial) -1.21429
TNNT2 troponin T type 2 (cardiac) -1.20347
DCTN3 dynactin 3 (p22) -1.1819
CALM2 calmodulin 2 (phosphorylase kinase, delta) -1.14457
CPA4 carboxypeptidase A4 -1.13492
MXD3 MAX dimerization protein 3 -1.10748
SERTAD4 SERTA domain containing 4 -1.10607
MARCKSL1 MARCKS-like 1 -1.09522
CENPM centromere protein M -1.05467
RRM2 ribonucleotide reductase M2 -1.03682
PDLIM1 PDZ and LIM domain 1 -0.999303
PEBP1 phosphatidylethanolamine binding protein 1 -0.992284
WNT5B wingless-type MMTV integration site family, member 5B -0.982255
SMIM29 small integral membrane protein 29 -0.940777
PHF19 PHD finger protein 19 -0.940777
GPC1 glypican 1 -0.922083
COMMD4 COMM domain containing 4 -0.909771
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.900406
ZNHIT1 zinc finger, HIT-type containing 1 -0.88449
FSTL1 follistatin-like 1 -0.880942
CDK4 cyclin-dependent kinase 4 -0.873864
MAB21L4 mab-21 like 4 -0.871557
TPI1 triosephosphate isomerase 1 -0.857321
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.856003
AP2M1 adaptor-related protein complex 2, mu 1 subunit -0.854939
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.849668
TYMS thymidylate synthetase -0.844239
CAV1 caveolin 1, caveolae protein, 22kDa -0.844069
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.836872
PCLAF PCNA clamp associated factor -0.806662
ANXA2 annexin A2 -0.786386
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 -0.786068
COA3 cytochrome c oxidase assembly factor 3 -0.759796
RPS27L ribosomal protein S27-like -0.759031
HIGD2A HIG1 hypoxia inducible domain family, member 2A -0.757972
ELAVL1 ELAV like RNA binding protein 1 -0.742548
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -0.720962
PDLIM2 PDZ and LIM domain 2 (mystique) -0.717347
TXNRD2 thioredoxin reductase 2 -0.707091
WNT11 wingless-type MMTV integration site family, member 11 -0.694396
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin -0.69142
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -0.69084
SKA2 spindle and kinetochore associated complex subunit 2 -0.678203
PLK2 polo-like kinase 2 -0.676595
SELENOH selenoprotein H -0.676595
S100A2 S100 calcium binding protein A2 -0.668669
CNN3 calponin 3, acidic -0.667367
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -0.64872
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) -0.631395
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -0.608246
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog -0.606587
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.605964
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.605135
DCTN2 dynactin 2 (p50) -0.605055
ADI1 acireductone dioxygenase 1 -0.589398
PHPT1 phosphohistidine phosphatase 1 -0.586667
DYNLL1 dynein, light chain, LC8-type 1 -0.579287
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa -0.568267
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -0.567767
TNS3 tensin 3 -0.565629
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.559492
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.558744
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -0.55766
DEF8 differentially expressed in FDCP 8 homolog (mouse) -0.549176
SEPHS1 selenophosphate synthetase 1 -0.539273
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -0.524854
WASHC2A WASH complex subunit 2A -0.523488
IRS1 insulin receptor substrate 1 -0.51962
C1ORF198 chromosome 1 open reading frame 198 -0.51962
GLI3 GLI family zinc finger 3 -0.516662
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.514823
PTMA prothymosin, alpha -0.507358
HRNR hornerin -0.500926
SYNPO synaptopodin -0.497343
PFKL phosphofructokinase, liver -0.495993
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 -0.495004
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -0.489509
SIVA1 SIVA1, apoptosis-inducing factor -0.476505
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -0.472212
GNAS GNAS complex locus -0.470776
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -0.467504
TAGLN transgelin -0.465295
LRRN1 leucine rich repeat neuronal 1 -0.463565
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.456633
ERG28 ergosterol biosynthesis 28 homolog -0.456017
PMF1-BGLAP PMF1-BGLAP readthrough -0.454648
RPS20 ribosomal protein S20 -0.454071
PCBP1 poly(rC) binding protein 1 -0.453882
ATP5MC1 ATP synthase membrane subunit c locus 1 -0.44925
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.448333
SRSF2 serine/arginine-rich splicing factor 2 -0.447097
ANXA10 annexin A10 -0.446422
SPAG5 sperm associated antigen 5 -0.442839
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa -0.441304
RUNX1 runt-related transcription factor 1 -0.439964
GTSE1 G-2 and S-phase expressed 1 -0.435313
TOP2A topoisomerase (DNA) II alpha 170kDa -0.43326
RAP2B RAP2B, member of RAS oncogene family -0.432453
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -0.432327
RIPOR2 RHO family interacting cell polarization regulator 2 -0.429237
YBX1 Y box binding protein 1 -0.428176
RBP1 retinol binding protein 1, cellular -0.417914
CAPN2 calpain 2, (m/II) large subunit -0.417432
ANXA8L1 annexin A8-like 1 -0.416615
BIRC7 baculoviral IAP repeat containing 7 -0.415494
SELENOW selenoprotein W -0.41323
SRSF3 serine/arginine-rich splicing factor 3 -0.411069
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -0.40927
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 -0.407131
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -0.406572
MFAP2 microfibrillar-associated protein 2 -0.401121
PBX3 pre-B-cell leukemia homeobox 3 -0.400963
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.394987
FHL2 four and a half LIM domains 2 -0.392432
TFDP1 transcription factor Dp-1 -0.387995
RAB34 RAB34, member RAS oncogene family -0.380512
FANCG Fanconi anemia, complementation group G -0.379739
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -0.377784
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.377508
NDN necdin, melanoma antigen (MAGE) family member -0.375664
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.371194
CSDE1 cold shock domain containing E1, RNA-binding -0.370834
TP53INP1 tumor protein p53 inducible nuclear protein 1 -0.370447
LOXL4 lysyl oxidase-like 4 -0.36259
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -0.36139
MED24 mediator complex subunit 24 -0.358625
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.356939
SNRPG small nuclear ribonucleoprotein polypeptide G -0.355612
GAS6 growth arrest-specific 6 -0.352042
RIN1 Ras and Rab interactor 1 -0.348495
LIMK2 LIM domain kinase 2 -0.346633
PXMP2 peroxisomal membrane protein 2, 22kDa -0.34578
GINS2 GINS complex subunit 2 (Psf2 homolog) -0.344235
EIF4A3 eukaryotic translation initiation factor 4A3 -0.342282
RAN RAN, member RAS oncogene family -0.341461
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -0.336823
TUBG1 tubulin, gamma 1 -0.333003
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -0.333003
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -0.332036
WDR33 WD repeat domain 33 -0.329581
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.328308
STOML2 stomatin (EPB72)-like 2 -0.325552
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -0.325396
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.32466
PARVA parvin, alpha -0.322158
GPX1 glutathione peroxidase 1 -0.32162
GOPC golgi-associated PDZ and coiled-coil motif containing -0.314864
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.313366
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -0.309995
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa -0.307613
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -0.307399
FAM136A family with sequence similarity 136, member A -0.307092
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.303799
EIF4E2 eukaryotic translation initiation factor 4E family member 2 -0.301496
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -0.301219
ARL4C ADP-ribosylation factor-like 4C -0.300234
C22ORF39 chromosome 22 open reading frame 39 -0.300234
EID1 EP300 interacting inhibitor of differentiation 1 -0.29961
RHOA ras homolog family member A -0.299464
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.299145
ERH enhancer of rudimentary homolog (Drosophila) -0.29261
LCTL lactase-like -0.291372
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.291372
AXL AXL receptor tyrosine kinase -0.286769
PRDX2 peroxiredoxin 2 -0.285868
ANKRD13A ankyrin repeat domain 13A -0.285119
PTPN21 protein tyrosine phosphatase, non-receptor type 21 -0.284814
RAVER1 ribonucleoprotein, PTB-binding 1 -0.283527
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -0.283069
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -0.281917
CCDC80 coiled-coil domain containing 80 -0.280082
FEN1 flap structure-specific endonuclease 1 -0.27906
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -0.277602
HCCS holocytochrome c synthase -0.277182
IRAK1 interleukin-1 receptor-associated kinase 1 -0.274056
FBXO9 F-box protein 9 -0.272997
CPT2 carnitine palmitoyltransferase 2 -0.272997
ABLIM1 actin binding LIM protein 1 -0.272512
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 -0.272067
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.269803
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.2698
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -0.26821
RUSC1 RUN and SH3 domain containing 1 -0.267205
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.267205
TUBB4B tubulin, beta 4B class IVb -0.266627
RHOBTB3 Rho-related BTB domain containing 3 -0.266195
RPL26L1 ribosomal protein L26-like 1 -0.265935
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.265935
THOP1 thimet oligopeptidase 1 -0.26512
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.264209
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -0.260031
SRSF9 serine/arginine-rich splicing factor 9 -0.260031
FAM210B family with sequence similarity 210, member B -0.259743
SET SET nuclear proto-oncogene -0.259525
TPGS2 tubulin polyglutamylase complex subunit 2 -0.257714
PRDX3 peroxiredoxin 3 -0.257681
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.255147
TTF2 transcription termination factor, RNA polymerase II -0.254561
HOXC11 homeobox C11 -0.254147
TMSB4X thymosin beta 4, X-linked -0.253968
COPS9 COP9 signalosome subunit 9 -0.253896
CDCA3 cell division cycle associated 3 -0.25387
KRT80 keratin 80, type II -0.253233
HMGB2 high mobility group box 2 -0.250591
ZRANB1 zinc finger, RAN-binding domain containing 1 -0.249009
CHML choroideremia-like (Rab escort protein 2) -0.248133
AURKA aurora kinase A -0.248077
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -0.247768
LDHA lactate dehydrogenase A -0.247277
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -0.247179
NIPSNAP3A nipsnap homolog 3A (C. elegans) -0.246936
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.244128
PRKD3 protein kinase D3 -0.243498
SYCP2 synaptonemal complex protein 2 -0.242554
MED28 mediator complex subunit 28 -0.240655
MCM4 minichromosome maintenance complex component 4 -0.239791
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa -0.238406
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -0.237175
UCK1 uridine-cytidine kinase 1 -0.236087
FST follistatin -0.2318
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.2318
TARBP2 TAR (HIV-1) RNA binding protein 2 -0.231466
LAMA5 laminin, alpha 5 -0.231288
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -0.230591
C6ORF15 chromosome 6 open reading frame 15 -0.229638
MOB3B MOB kinase activator 3B -0.228685
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -0.228135
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -0.228135
TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) -0.227345
C8ORF58 chromosome 8 open reading frame 58 -0.227082
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.226715
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.226715
TUBB6 tubulin, beta 6 class V -0.223498
RGCC regulator of cell cycle -0.221719
MRPL20 mitochondrial ribosomal protein L20 -0.221098
LYPD1 LY6/PLAUR domain containing 1 -0.220134
SPAG7 sperm associated antigen 7 -0.217518
CDCA8 cell division cycle associated 8 -0.217387
CLTA clathrin, light chain A -0.217083
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.216736
CHD1L chromodomain helicase DNA binding protein 1-like -0.216569
UHRF1 ubiquitin-like with PHD and ring finger domains 1 -0.21507
ILF2 interleukin enhancer binding factor 2 -0.214225
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.212235
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -0.212167
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.211921
MSI2 musashi RNA-binding protein 2 -0.210807
PPP1R7 protein phosphatase 1, regulatory subunit 7 -0.210807
HRCT1 histidine rich carboxyl terminus 1 -0.209579
MICALL2 MICAL-like 2 -0.209484
CS citrate synthase -0.209424
SND1 staphylococcal nuclease and tudor domain containing 1 -0.209381
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.208908
CENPS-CORT CENPS-CORT readthrough -0.208581
RTF2 replication termination factor 2 -0.20813
CCDC9B coiled-coil domain containing 9B -0.2063
PTBP1 polypyrimidine tract binding protein 1 -0.206239
DPYSL2 dihydropyrimidinase-like 2 -0.205689
KTN1 kinectin 1 (kinesin receptor) -0.205404
RPL23A ribosomal protein L23a -0.205404
PHF12 PHD finger protein 12 -0.204399
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -0.204399
ATP5PF ATP synthase peripheral stalk subunit F6 -0.203478
PEF1 penta-EF-hand domain containing 1 -0.20342
MELK maternal embryonic leucine zipper kinase -0.202666
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.202198