OB-78-PA58_0.01uM Gene Set

Dataset	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category	transcriptomics
Type	drug perturbation
Description	Dose=0.01uM, Teglarinad, Glycerol-3-Phosphate Dehydrogenase (NAD+) Inhibitors;Nicotinamide Phosphoribosyltransferase (NMPRTase) Inhibitors;Signal Transduction Modulators;Inhibitory kappaB Kinase (IKK) Inhibitors targeting GPD1, NAMPT, CHUK (Novartis, 9961435)
External Link	https://pubchem.ncbi.nlm.nih.gov/compound/9961435
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Genes

13 genes differentially expressed following the OB-78-PA58_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol	Name	Standardized Value
RPS16	ribosomal protein S16	0.698766
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.552685
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.337366
PPIC	peptidylprolyl isomerase C (cyclophilin C)	0.307267
FKBP1A	FK506 binding protein 1A, 12kDa	0.261607
TIMM8B	translocase of inner mitochondrial membrane 8 homolog B (yeast)	0.207064
ZNF90	zinc finger protein 90	0.204116

decreased expression

Symbol	Name	Standardized Value
CDK6	cyclin-dependent kinase 6	-0.403028
TMEM245	transmembrane protein 245	-0.304108
RNF34	ring finger protein 34, E3 ubiquitin protein ligase	-0.210593
ANKRD10	ankyrin repeat domain 10	-0.210593
INTS10	integrator complex subunit 10	-0.204116
CERK	ceramide kinase	-0.201895