OB-78-PA58_10uM Gene Set
Genes
49 genes differentially expressed following the OB-78-PA58_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
MT2A
|
metallothionein 2A
|
2.95998
|
|
MT1E
|
metallothionein 1E
|
2.5152
|
|
MYL2
|
myosin, light chain 2, regulatory, cardiac, slow
|
1.71286
|
|
SCNN1A
|
sodium channel, non voltage gated 1 alpha subunit
|
1.70517
|
|
DDIT4
|
DNA-damage-inducible transcript 4
|
1.52852
|
|
SERPINE1
|
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
|
1.3406
|
|
RPS16
|
ribosomal protein S16
|
0.712863
|
|
SPCS1
|
signal peptidase complex subunit 1 homolog (S. cerevisiae)
|
0.633963
|
|
GMPR
|
guanosine monophosphate reductase
|
0.606327
|
|
BEX2
|
brain expressed X-linked 2
|
0.606327
|
|
MYL6
|
myosin, light chain 6, alkali, smooth muscle and non-muscle
|
0.562144
|
|
RPL37
|
ribosomal protein L37
|
0.470418
|
|
RPS18
|
ribosomal protein S18
|
0.412587
|
|
MT1X
|
metallothionein 1X
|
0.389223
|
|
CAV1
|
caveolin 1, caveolae protein, 22kDa
|
0.36758
|
|
PTPN11
|
protein tyrosine phosphatase, non-receptor type 11
|
0.362595
|
|
HSPB1
|
heat shock 27kDa protein 1
|
0.362595
|
|
PER1
|
period circadian clock 1
|
0.348066
|
|
NFKBIA
|
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
|
0.316815
|
|
CEBPB
|
CCAAT/enhancer binding protein (C/EBP), beta
|
0.310939
|
|
TMSB10
|
thymosin beta 10
|
0.296915
|
|
SMG8
|
SMG8 nonsense mediated mRNA decay factor
|
0.292151
|
|
SAA2
|
serum amyloid A2
|
0.273696
|
|
PPIC
|
peptidylprolyl isomerase C (cyclophilin C)
|
0.267447
|
|
RPL15
|
ribosomal protein L15
|
0.25403
|
|
CRYAB
|
crystallin, alpha B
|
0.228513
|
|
PPDPF
|
pancreatic progenitor cell differentiation and proliferation factor
|
0.224443
|
|
GAPDH
|
glyceraldehyde-3-phosphate dehydrogenase
|
0.212433
|
|
MRPL52
|
mitochondrial ribosomal protein L52
|
0.204902
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
KRT17
|
keratin 17, type I
|
-1.12245
|
|
IER3
|
immediate early response 3
|
-0.75241
|
|
COTL1
|
coactosin-like F-actin binding protein 1
|
-0.62529
|
|
SERTAD4
|
SERTA domain containing 4
|
-0.382872
|
|
LAYN
|
layilin
|
-0.362595
|
|
KRTAP2-3
|
keratin associated protein 2-3
|
-0.34937
|
|
TAGLN
|
transgelin
|
-0.332793
|
|
ACTG1
|
actin gamma 1
|
-0.320793
|
|
FGF1
|
fibroblast growth factor 1 (acidic)
|
-0.292151
|
|
MRPL14
|
mitochondrial ribosomal protein L14
|
-0.27223
|
|
RPL32
|
ribosomal protein L32
|
-0.268083
|
|
BOP1
|
block of proliferation 1
|
-0.25887
|
|
IGFBP5
|
insulin-like growth factor binding protein 5
|
-0.256091
|
|
SELENOF
|
selenoprotein F
|
-0.234318
|
|
PDLIM1
|
PDZ and LIM domain 1
|
-0.231759
|
|
RASGRF1
|
Ras protein-specific guanine nucleotide-releasing factor 1
|
-0.228513
|
|
CNN1
|
calponin 1, basic, smooth muscle
|
-0.207499
|
|
OSBP2
|
oxysterol binding protein 2
|
-0.203895
|
|
BOD1
|
biorientation of chromosomes in cell division 1
|
-0.203895
|
|
DEPP1
|
DEPP autophagy regulator 1
|
-0.203895
|
