OB-78-PA58_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM, Teglarinad, Glycerol-3-Phosphate Dehydrogenase (NAD+) Inhibitors;Nicotinamide Phosphoribosyltransferase (NMPRTase) Inhibitors;Signal Transduction Modulators;Inhibitory kappaB Kinase (IKK) Inhibitors targeting GPD1, NAMPT, CHUK (Novartis, 9961435)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9961435
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Genes

303 genes differentially expressed following the OB-78-PA58_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
MRPL52 mitochondrial ribosomal protein L52 2.23537
RPL35 ribosomal protein L35 2.15964
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 1.93063
MT2A metallothionein 2A 1.53015
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.52286
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.48165
MT1E metallothionein 1E 1.16285
RPS15 ribosomal protein S15 1.15036
RPS18 ribosomal protein S18 1.12601
MRPL58 mitochondrial ribosomal protein L58 1.12576
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.984269
GSTP1 glutathione S-transferase pi 1 0.984269
EIF3K eukaryotic translation initiation factor 3, subunit K 0.977642
ELOB elongin B 0.966184
ECI1 enoyl-CoA delta isomerase 1 0.927361
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.847821
RNF181 ring finger protein 181 0.816085
CCNI cyclin I 0.815268
RPL37 ribosomal protein L37 0.789456
ZNF593 zinc finger protein 593 0.767346
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 0.736234
BEX2 brain expressed X-linked 2 0.721741
RPL36 ribosomal protein L36 0.701206
RPL11 ribosomal protein L11 0.701206
ZNRD2 zinc ribbon domain containing 2 0.663148
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.656286
TARDBP TAR DNA binding protein 0.654215
NNMT nicotinamide N-methyltransferase 0.649792
RPL19 ribosomal protein L19 0.638136
HSPB1 heat shock 27kDa protein 1 0.625513
COX5B cytochrome c oxidase subunit Vb 0.624505
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.622401
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.606431
RPL18 ribosomal protein L18 0.600396
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.600155
RSL24D1 ribosomal L24 domain containing 1 0.59374
RUVBL2 RuvB-like AAA ATPase 2 0.579318
RPL8 ribosomal protein L8 0.577352
TUBA3C tubulin, alpha 3c 0.577352
RPL30 ribosomal protein L30 0.572681
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.542786
SNRPC small nuclear ribonucleoprotein polypeptide C 0.529168
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.520315
FES FES proto-oncogene, tyrosine kinase 0.520315
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.515013
DCXR dicarbonyl/L-xylulose reductase 0.512278
SAA2 serum amyloid A2 0.507486
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.501012
MRPL36 mitochondrial ribosomal protein L36 0.499673
UXT ubiquitously-expressed, prefoldin-like chaperone 0.490505
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.488338
RPS26 ribosomal protein S26 0.486942
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa 0.482389
MRPL40 mitochondrial ribosomal protein L40 0.473013
DCTPP1 dCTP pyrophosphatase 1 0.469342
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.468761
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 0.464016
NOL7 nucleolar protein 7, 27kDa 0.459399
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.459399
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.459124
PHACTR3 phosphatase and actin regulator 3 0.453482
ANXA2 annexin A2 0.446742
AUP1 ancient ubiquitous protein 1 0.444864
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 0.443449
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 0.440839
ATP5F1D ATP synthase F1 subunit delta 0.433727
TPM2 tropomyosin 2 (beta) 0.432744
SNU13 small nuclear ribonucleoprotein 13 0.429142
MRPL20 mitochondrial ribosomal protein L20 0.428947
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.422517
PFN1 profilin 1 0.418057
FBL fibrillarin 0.417919
MRPL17 mitochondrial ribosomal protein L17 0.410728
PER1 period circadian clock 1 0.396528
HIRIP3 HIRA interacting protein 3 0.386533
ATP5MC1 ATP synthase membrane subunit c locus 1 0.383034
RPP21 ribonuclease P/MRP 21kDa subunit 0.382331
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) 0.379345
MYL12B myosin, light chain 12B, regulatory 0.377676
RPS28 ribosomal protein S28 0.365415
RPS4X ribosomal protein S4, X-linked 0.362335
CDKN3 cyclin-dependent kinase inhibitor 3 0.36223
EIF3I eukaryotic translation initiation factor 3, subunit I 0.360528
IMP4 IMP4, U3 small nucleolar ribonucleoprotein 0.358547
ATP5ME ATP synthase membrane subunit e 0.355539
CDC20 cell division cycle 20 0.355539
NT5C 5', 3'-nucleotidase, cytosolic 0.353271
RPL4 ribosomal protein L4 0.349793
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.347292
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.342766
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.340564
PHPT1 phosphohistidine phosphatase 1 0.33763
PPME1 protein phosphatase methylesterase 1 0.334093
RPS10 ribosomal protein S10 0.332028
LBHD1 LBH domain containing 1 0.33148
BLVRB biliverdin reductase B 0.328737
DDTL D-dopachrome tautomerase-like 0.327516
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 0.324905
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.315964
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.315934
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.315934
PEX39 peroxisomal biogenesis factor 39 0.315934
EDF1 endothelial differentiation-related factor 1 0.31546
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.31401
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 0.313699
TRAPPC2L trafficking protein particle complex 2-like 0.308463
NOL12 nucleolar protein 12 0.30609
C19ORF53 chromosome 19 open reading frame 53 0.304967
CAV1 caveolin 1, caveolae protein, 22kDa 0.300919
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 0.300612
NHP2 NHP2 ribonucleoprotein 0.300294
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.297492
SCAND1 SCAN domain containing 1 0.293256
RPL15 ribosomal protein L15 0.292566
RPL7A ribosomal protein L7a 0.291083
RPS16 ribosomal protein S16 0.287042
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.285456
ATP5IF1 ATP synthase inhibitory factor subunit 1 0.281076
C19ORF33 chromosome 19 open reading frame 33 0.278951
MRPL12 mitochondrial ribosomal protein L12 0.278951
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.275145
TMEM205 transmembrane protein 205 0.275145
GTF2A2 general transcription factor IIA, 2, 12kDa 0.273633
RUVBL1 RuvB-like AAA ATPase 1 0.271378
ALG3 ALG3, alpha-1,3- mannosyltransferase 0.271378
UBC ubiquitin C 0.270603
ATP5MF ATP synthase membrane subunit f 0.268655
MRPS21 mitochondrial ribosomal protein S21 0.268067
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 0.263613
AK2 adenylate kinase 2 0.256759
TXNDC17 thioredoxin domain containing 17 0.254385
CORO7-PAM16 CORO7-PAM16 readthrough 0.2539
EIF6 eukaryotic translation initiation factor 6 0.253044
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 0.252309
PFDN5 prefoldin subunit 5 0.250846
EIF3L eukaryotic translation initiation factor 3, subunit L 0.25058
EXOSC8 exosome component 8 0.250298
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.2494
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.248739
PTRH2 peptidyl-tRNA hydrolase 2 0.247851
ATP5F1A ATP synthase F1 subunit alpha 0.247851
YDJC YdjC homolog (bacterial) 0.247661
ATF4 activating transcription factor 4 0.246573
VSTM1 V-set and transmembrane domain containing 1 0.246329
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.246329
RPL27 ribosomal protein L27 0.246156
DYNLL1 dynein, light chain, LC8-type 1 0.24453
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 0.243909
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.240885
GRHPR glyoxylate reductase/hydroxypyruvate reductase 0.240786
NME1-NME2 NME1-NME2 readthrough 0.239753
RPL7 ribosomal protein L7 0.239646
GFER growth factor, augmenter of liver regeneration 0.239163
MRPL13 mitochondrial ribosomal protein L13 0.239084
LGALS1 lectin, galactoside-binding, soluble, 1 0.238591
ALPP alkaline phosphatase, placental 0.237732
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.236174
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.233779
HINT2 histidine triad nucleotide binding protein 2 0.233542
MRPL41 mitochondrial ribosomal protein L41 0.226756
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.224773
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.224153
NOP56 NOP56 ribonucleoprotein 0.223668
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.222542
PFDN2 prefoldin subunit 2 0.219217
PPIH peptidylprolyl isomerase H (cyclophilin H) 0.218918
RPL26 ribosomal protein L26 0.215851
EXOSC1 exosome component 1 0.21584
PHF5A PHD finger protein 5A 0.213161
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.211783
TMSB10 thymosin beta 10 0.210989
NACA nascent polypeptide-associated complex alpha subunit 0.210989
COA3 cytochrome c oxidase assembly factor 3 0.210282
AURKAIP1 aurora kinase A interacting protein 1 0.210136
RPL29 ribosomal protein L29 0.208728
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 0.208215
RPL10L ribosomal protein L10-like 0.207953
SAP30BP SAP30 binding protein 0.207953
LEPROTL1 leptin receptor overlapping transcript-like 1 0.207068
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.204343
RAB11A RAB11A, member RAS oncogene family 0.203454
MRPS15 mitochondrial ribosomal protein S15 0.203183
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.202785
ETFB electron-transfer-flavoprotein, beta polypeptide 0.202339
RSL1D1 ribosomal L1 domain containing 1 0.201998
RPS17 ribosomal protein S17 0.20104
CD63 CD63 molecule 0.200971

decreased expression

Symbol Name Standardized Value
IER3 immediate early response 3 -2.14103
TMSB4X thymosin beta 4, X-linked -1.35607
HAPLN1 hyaluronan and proteoglycan link protein 1 -1.34758
METRNL meteorin, glial cell differentiation regulator-like -1.3255
KRT17 keratin 17, type I -1.13766
ERG28 ergosterol biosynthesis 28 homolog -1.0978
PDLIM1 PDZ and LIM domain 1 -1.01099
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.989931
IGFBP5 insulin-like growth factor binding protein 5 -0.989529
CPA4 carboxypeptidase A4 -0.977642
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.961074
TGFBI transforming growth factor, beta-induced, 68kDa -0.918991
ARL4C ADP-ribosylation factor-like 4C -0.85249
SMIM29 small integral membrane protein 29 -0.85249
CNN3 calponin 3, acidic -0.847821
KRTAP2-3 keratin associated protein 2-3 -0.847821
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.838724
TPM1 tropomyosin 1 (alpha) -0.838724
GLS2 glutaminase 2 (liver, mitochondrial) -0.80958
SDF2L1 stromal cell-derived factor 2-like 1 -0.803421
CXCL14 chemokine (C-X-C motif) ligand 14 -0.759492
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.734798
ACTG1 actin gamma 1 -0.726242
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.701206
AMIGO2 adhesion molecule with Ig-like domain 2 -0.699108
GSN gelsolin -0.691976
MAGED1 melanoma antigen family D1 -0.691976
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -0.657074
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.638136
FHL2 four and a half LIM domains 2 -0.600958
NREP neuronal regeneration related protein -0.566218
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.557319
TMED9 transmembrane emp24 protein transport domain containing 9 -0.551611
MFAP2 microfibrillar-associated protein 2 -0.537927
TIMP3 TIMP metallopeptidase inhibitor 3 -0.499673
CALB2 calbindin 2 -0.496303
CCL26 chemokine (C-C motif) ligand 26 -0.462778
LARP6 La ribonucleoprotein domain family, member 6 -0.459418
PER3 period circadian clock 3 -0.443449
CRELD1 cysteine-rich with EGF-like domains 1 -0.433651
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.42548
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -0.401575
HDAC5 histone deacetylase 5 -0.396942
MAB21L4 mab-21 like 4 -0.394839
WNT5B wingless-type MMTV integration site family, member 5B -0.391429
DHCR7 7-dehydrocholesterol reductase -0.391429
LOC112694756 uncharaterized LOC112694756 -0.38778
SCX scleraxis basic helix-loop-helix transcription factor -0.382331
WNT11 wingless-type MMTV integration site family, member 11 -0.368598
FAM171A1 family with sequence similarity 171, member A1 -0.365415
TMEM37 transmembrane protein 37 -0.355837
ULK1 unc-51 like autophagy activating kinase 1 -0.353343
MICA MHC class I polypeptide-related sequence A -0.352556
FOXD1 forkhead box D1 -0.351128
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.342312
KRT15 keratin 15, type I -0.342312
GLI3 GLI family zinc finger 3 -0.338883
MMP2 matrix metallopeptidase 2 -0.330592
VMP1 vacuole membrane protein 1 -0.327516
PGK1 phosphoglycerate kinase 1 -0.322224
GLRX glutaredoxin (thioltransferase) -0.319371
VGLL4 vestigial-like family member 4 -0.318646
ANXA6 annexin A6 -0.310752
EIF4E2 eukaryotic translation initiation factor 4E family member 2 -0.30378
IL18 interleukin 18 -0.300919
PLPP4 phospholipid phosphatase 4 -0.298059
RUNX1 runt-related transcription factor 1 -0.29375
CDK4 cyclin-dependent kinase 4 -0.289602
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -0.278951
P3H1 prolyl 3-hydroxylase 1 -0.278698
JUND jun D proto-oncogene -0.273633
CEMIP2 cell migration inducing hyaluronidase 2 -0.27332
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.268893
DEPP1 DEPP autophagy regulator 1 -0.266748
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -0.259843
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.252309
GID8 GID complex subunit 8 -0.252041
RAB11FIP4 RAB11 family interacting protein 4 (class II) -0.251519
DHCR24 24-dehydrocholesterol reductase -0.250846
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.250701
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.250624
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.247851
MARCKSL1 MARCKS-like 1 -0.245274
LYPD1 LY6/PLAUR domain containing 1 -0.239622
ZCCHC24 zinc finger, CCHC domain containing 24 -0.234951
MCM7 minichromosome maintenance complex component 7 -0.234877
PSPH phosphoserine phosphatase -0.233584
RIMS3 regulating synaptic membrane exocytosis 3 -0.230541
METTL9 methyltransferase like 9 -0.225721
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -0.225348
CALR calreticulin -0.224773
SMCO4 single-pass membrane protein with coiled-coil domains 4 -0.224773
ACOT7 acyl-CoA thioesterase 7 -0.224698
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.222705
RTL8C retrotransposon Gag like 8C -0.222542
CD81 CD81 molecule -0.222542
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.221067
SOX9 SRY (sex determining region Y)-box 9 -0.2202
TMSB15B thymosin beta 15B -0.219228
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.214421
F2R coagulation factor II (thrombin) receptor -0.213409
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -0.210989
RNF24 ring finger protein 24 -0.210282
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 -0.209561
RRM2 ribonucleotide reductase M2 -0.209099
HES6 hes family bHLH transcription factor 6 -0.206861
CCN2 cellular communication network factor 2 -0.206314
LDHA lactate dehydrogenase A -0.206314
LRRN1 leucine rich repeat neuronal 1 -0.206151
KIF20B kinesin family member 20B -0.204343
NF2 neurofibromin 2 (merlin) -0.20371
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.20371
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.203183
E2F7 E2F transcription factor 7 -0.20208
CXXC5 CXXC finger protein 5 -0.202074
TRIB3 tribbles pseudokinase 3 -0.200415