OE-04-VO07_0.01uM Gene Set

Dataset	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category	transcriptomics
Type	drug perturbation
Description	Dose=0.01uM, 2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-5-((2-(methylsulfinyl)pyridin-3-yl)methyl)-4-(trifluoromethyl)-1H-benzo[d]imidazole, Calcium-Sensing Receptor (CaSR) Antagonists targeting CASR (Novartis, 24753707)
External Link	https://pubchem.ncbi.nlm.nih.gov/compound/24753707
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Genes

12 genes differentially expressed following the OE-04-VO07_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol	Name	Standardized Value
LDHB	lactate dehydrogenase B	0.608103
UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1	0.53993
UBD	ubiquitin D	0.439616
ENAM	enamelin	0.322739
ANAPC16	anaphase promoting complex subunit 16	0.25512
RPL27A	ribosomal protein L27a	0.250187
UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.250187
CRYAB	crystallin, alpha B	0.247187
RPS16	ribosomal protein S16	0.239358

decreased expression

Symbol	Name	Standardized Value
ACOT9	acyl-CoA thioesterase 9	-0.222053
ING4	inhibitor of growth family, member 4	-0.222053
TRAF3IP2	TRAF3 interacting protein 2	-0.202391