OE-04-VO07_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, 2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-5-((2-(methylsulfinyl)pyridin-3-yl)methyl)-4-(trifluoromethyl)-1H-benzo[d]imidazole, Calcium-Sensing Receptor (CaSR) Antagonists targeting CASR (Novartis, 24753707)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/24753707
Similar Terms
Downloads & Tools

Genes

46 genes differentially expressed following the OE-04-VO07_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
RPL8 ribosomal protein L8 0.914337
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.765445
LDHB lactate dehydrogenase B 0.734006
FTL ferritin, light polypeptide 0.559659
APRT adenine phosphoribosyltransferase 0.53005
RPS16 ribosomal protein S16 0.430224
RPS18 ribosomal protein S18 0.400917
RPS11 ribosomal protein S11 0.393042
SSR4 signal sequence receptor, delta 0.382035
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.381976
RPL27A ribosomal protein L27a 0.377507
UBC ubiquitin C 0.370993
BEST1 bestrophin 1 0.356526
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.328325
RPL13A ribosomal protein L13a 0.32057
RPS27 ribosomal protein S27 0.301726
RPL18A ribosomal protein L18a 0.301389
RPL36 ribosomal protein L36 0.286696
TMSB10 thymosin beta 10 0.280846
ATP5PO ATP synthase peripheral stalk subunit OSCP 0.279836
ELOB elongin B 0.276185
RPS17 ribosomal protein S17 0.273871
UPP1 uridine phosphorylase 1 0.27242
FTH1 ferritin, heavy polypeptide 1 0.268927
BLVRB biliverdin reductase B 0.255566
RPL19 ribosomal protein L19 0.242944
RPS13 ribosomal protein S13 0.238895
RPL15 ribosomal protein L15 0.238534
RPL28 ribosomal protein L28 0.238352
CRYAB crystallin, alpha B 0.237416
RPS5 ribosomal protein S5 0.237416
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.221534
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.221026
ECI1 enoyl-CoA delta isomerase 1 0.215553
PFDN5 prefoldin subunit 5 0.215553
RPS23 ribosomal protein S23 0.21282
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.21282
GSTP1 glutathione S-transferase pi 1 0.212398
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.209579
TIMP1 TIMP metallopeptidase inhibitor 1 0.207689
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 0.20189

decreased expression

Symbol Name Standardized Value
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.53005
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.30969
TAGLN transgelin -0.273871
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.212398
ACTG1 actin gamma 1 -0.206135