OE-50-VB46_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, 4-hydroxy7-(1-hydroxy-2-{2-[4-(4-phenyl-butoxy)-phenyl]-ethylamino}-ethyl)-3H-benzothiazol-2-one, beta2-Adrenoceptor Agonists targeting ADRB2 (Novartis, 9805095)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9805095
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Genes

43 genes differentially expressed following the OE-50-VB46_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.06522
CIB1 calcium and integrin binding 1 (calmyrin) 1.01111
DDIT4 DNA-damage-inducible transcript 4 0.917791
RPL37 ribosomal protein L37 0.917791
RPL31 ribosomal protein L31 0.894828
MVD mevalonate (diphospho) decarboxylase 0.847392
SH3D19 SH3 domain containing 19 0.697796
PGK1 phosphoglycerate kinase 1 0.687336
FKBP1A FK506 binding protein 1A, 12kDa 0.623242
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.610099
PGP phosphoglycolate phosphatase 0.609901
FDPS farnesyl diphosphate synthase 0.52709
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.491527
NNMT nicotinamide N-methyltransferase 0.491527
SERP1 stress-associated endoplasmic reticulum protein 1 0.446355
ERG28 ergosterol biosynthesis 28 homolog 0.420663
DHCR7 7-dehydrocholesterol reductase 0.417713
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.387081
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.350793
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.330485
LMBR1 limb development membrane protein 1 0.318078
TMEM97 transmembrane protein 97 0.302854
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.285605
C12ORF57 chromosome 12 open reading frame 57 0.267938
TPT1 tumor protein, translationally-controlled 1 0.265591
IL18 interleukin 18 0.255132
SOAT2 sterol O-acyltransferase 2 0.249971
ACSS2 acyl-CoA synthetase short-chain family member 2 0.246313
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.244811
MANBAL mannosidase, beta A, lysosomal-like 0.243489
TPI1 triosephosphate isomerase 1 0.23254
SMYD3 SET and MYND domain containing 3 0.231421
FADS2 fatty acid desaturase 2 0.220917

decreased expression

Symbol Name Standardized Value
TAGLN transgelin -0.418356
DTX3 deltex 3, E3 ubiquitin ligase -0.373629
PDLIM1 PDZ and LIM domain 1 -0.356709
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.287444
SRSF2 serine/arginine-rich splicing factor 2 -0.282936
SNCG synuclein, gamma (breast cancer-specific protein 1) -0.260838
COL1A1 collagen, type I, alpha 1 -0.255626
RPL32 ribosomal protein L32 -0.246313
SPACA6 sperm acrosome associated 6 -0.233882
UBA1 ubiquitin-like modifier activating enzyme 1 -0.231546