OE-50-VB46_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM, 4-hydroxy7-(1-hydroxy-2-{2-[4-(4-phenyl-butoxy)-phenyl]-ethylamino}-ethyl)-3H-benzothiazol-2-one, beta2-Adrenoceptor Agonists targeting ADRB2 (Novartis, 9805095)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9805095
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Genes

20 genes differentially expressed following the OE-50-VB46_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
FKBP1A FK506 binding protein 1A, 12kDa 0.929261
RPL37 ribosomal protein L37 0.397412
RPL30 ribosomal protein L30 0.397412
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.388914
CIB1 calcium and integrin binding 1 (calmyrin) 0.296416
BEX2 brain expressed X-linked 2 0.265366
RPL31 ribosomal protein L31 0.213924
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.213924
RPL35 ribosomal protein L35 0.21133

decreased expression

Symbol Name Standardized Value
MAGEB2 melanoma antigen family B2 -0.411105
CXCL14 chemokine (C-X-C motif) ligand 14 -0.406579
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.353541
WDR45 WD repeat domain 45 -0.258559
NGLY1 N-glycanase 1 -0.253105
LETM2 leucine zipper-EF-hand containing transmembrane protein 2 -0.252441
PHKB phosphorylase kinase, beta -0.252441
HELZ helicase with zinc finger -0.234984
FAR1 fatty acyl CoA reductase 1 -0.233693
NBR1 neighbor of BRCA1 gene 1 -0.233488
DLAT dihydrolipoamide S-acetyltransferase -0.217566