OE-75-WF43_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM, 8-(2-(3,5-Dimethylpiperazin-1-yl)-4- targeting EED (Novartis, 139346228)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/139346228
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Genes

30 genes differentially expressed following the OE-75-WF43_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.663766
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.663766
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.633552
RPS15 ribosomal protein S15 0.611341
CRYAB crystallin, alpha B 0.530881
RHOG ras homolog family member G 0.478675
C19ORF33 chromosome 19 open reading frame 33 0.366121
RPL31 ribosomal protein L31 0.353265
TMEM258 transmembrane protein 258 0.348122
LGALS1 lectin, galactoside-binding, soluble, 1 0.344916
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.326597
TNNI3 troponin I type 3 (cardiac) 0.31973
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 0.311151
TRAPPC1 trafficking protein particle complex 1 0.271378
PHPT1 phosphohistidine phosphatase 1 0.271378
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.26016
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.240727
MZT2B mitotic spindle organizing protein 2B 0.220391
ELOB elongin B 0.220391
RPL28 ribosomal protein L28 0.217019
HMOX2 heme oxygenase 2 0.216354
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.209267
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 0.207169

decreased expression

Symbol Name Standardized Value
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -0.348122
GOLGA4 golgin A4 -0.26016
CPA4 carboxypeptidase A4 -0.220391
LRRC37B leucine rich repeat containing 37B -0.220391
ISCU iron-sulfur cluster assembly enzyme -0.213378
PHF20L1 PHD finger protein 20-like 1 -0.211791
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.209267