OGDH Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)|This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 4967)
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Genes

312 genes differentially expressed following the OGDH gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM90A26 family with sequence similarity 90, member A26, pseudogene 2.35072
IL5RA interleukin 5 receptor, alpha 2.35072
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.35072
PAX8 paired box 8 2.35072
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.35072
DMRTC1B DMRT-like family C1B 2.35072
ADAD2 adenosine deaminase domain containing 2 2.35072
SLC23A3 solute carrier family 23, member 3 2.35072
LYZL6 lysozyme-like 6 2.35072
MYBPC1 myosin binding protein C, slow type 2.35072
TMEM176B transmembrane protein 176B 2.35072
CD14 CD14 molecule 2.35072
ALB albumin 2.35072
TXLNB taxilin beta 2.35072
VTN vitronectin 2.35072
VWA5B2 von Willebrand factor A domain containing 5B2 2.35072
COLEC10 collectin sub-family member 10 (C-type lectin) 2.35072
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.35072
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.35072
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.35072
FHL5 four and a half LIM domains 5 2.35072
BIRC7 baculoviral IAP repeat containing 7 2.35072
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.35072
S100A3 S100 calcium binding protein A3 2.35072
PNOC prepronociceptin 2.35072
PTCD2 pentatricopeptide repeat domain 2 2.35072
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.35072
BHMT2 betaine--homocysteine S-methyltransferase 2 2.35072
PRDM13 PR domain containing 13 2.35072
HMX3 H6 family homeobox 3 2.35072
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 2.35072
CRH corticotropin releasing hormone 2.35072
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.35072
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.35072
GCKR glucokinase (hexokinase 4) regulator 2.35072
LY6G6F lymphocyte antigen 6 complex, locus G6F 2.35072
BSX brain-specific homeobox 2.35072
GUCY2F guanylate cyclase 2F, retinal 2.35072
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 2.35072
ASPDH aspartate dehydrogenase domain containing 2.35072
RGPD3 RANBP2-like and GRIP domain containing 3 2.35072
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.35072
SPATA31H1 SPATA31 subfamily H member 1 2.35072
ROPN1L rhophilin associated tail protein 1-like 2.35072
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.35072
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 2.35072
SPRR2A small proline-rich protein 2A 2.35072
FMOD fibromodulin 2.35072
TREX2 three prime repair exonuclease 2 2.35072
FOXC1 forkhead box C1 2.35072
GC group-specific component (vitamin D binding protein) 2.35072
OTOS otospiralin 2.35072
TMEM271 transmembrane protein 271 2.35072
JAML junction adhesion molecule like 2.35072
OR2I1 olfactory receptor family 2 subfamily I member 1 (gene/pseudogene) 2.35072
ERLN endoregulin 2.35072
EXOC1L exocyst complex component 1 like 2.35072
ZNF593OS ZNF593 opposite strand 2.35072
H4C14 H4 clustered histone 14 2.35072
CFAP299 cilia and flagella associated protein 299 2.35072
DNAAF6 dynein axonemal assembly factor 6 2.35072
CFAP97D1 CFAP97 domain containing 1 2.35072
MYL10 myosin, light chain 10, regulatory 2.35072
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 2.35072
TLR8 toll-like receptor 8 2.35072
KRABD1 KRAB domain containing 1 2.35072
HOXC4 homeobox C4 2.35072
OR2J1 olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene) 2.35072
ITK IL2-inducible T-cell kinase 2.35072
TMEM95 transmembrane protein 95 2.35072
HDC histidine decarboxylase 2.35072
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.35072
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.35072
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.35072
IFNL2 interferon, lambda 2 2.35072
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.35072
CNTN6 contactin 6 2.35072
GPR85 G protein-coupled receptor 85 2.35072
PNPLA1 patatin-like phospholipase domain containing 1 2.35072
TRIP11 thyroid hormone receptor interactor 11 2.35072
EXOC3L4 exocyst complex component 3-like 4 2.35072
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.35072
PRR4 proline rich 4 (lacrimal) 2.35072
TPBGL trophoblast glycoprotein-like 2.35072
PRR22 proline rich 22 2.35072
ART1 ADP-ribosyltransferase 1 2.35072
TCP11X2 t-complex 11 family, X-linked 2 2.35072
NPFFR1 neuropeptide FF receptor 1 2.35072
TPSB2 tryptase beta 2 (gene/pseudogene) 2.35072
PLET1 placenta expressed transcript 1 2.35072
ERICH6B glutamate-rich 6B 2.35072
PRM1 protamine 1 2.35072
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.35072
DUOX2 dual oxidase 2 2.35072
CYSLTR1 cysteinyl leukotriene receptor 1 2.35072
CXCR6 chemokine (C-X-C motif) receptor 6 2.35072
LRTM2 leucine-rich repeats and transmembrane domains 2 2.35072
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.35072
CT55 cancer/testis antigen 55 2.35072
FIGNL2 fidgetin-like 2 2.35072
BRD4 bromodomain containing 4 2.35072
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 2.35072
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.35072
ODF4 outer dense fiber of sperm tails 4 2.35072
DRD2 dopamine receptor D2 2.35072
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.35072
OTP orthopedia homeobox 2.35072
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.35072
FAIM2 Fas apoptotic inhibitory molecule 2 2.35072
FECH ferrochelatase 2.35072
MYADML2 myeloid-associated differentiation marker-like 2 2.35072
LEUTX leucine twenty homeobox 2.35072
MOBP myelin-associated oligodendrocyte basic protein 2.35072
TMPPE transmembrane protein with metallophosphoesterase domain 2.35072
HAND2 heart and neural crest derivatives expressed 2 2.35072
TSPYL6 TSPY-like 6 2.35072
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.35072
CLEC9A C-type lectin domain family 9, member A 2.35072
NT5DC4 5'-nucleotidase domain containing 4 2.35072
ZNF80 zinc finger protein 80 2.35072
RAB29 RAB29, member RAS oncogene family 2.35072
PCDHGA2 protocadherin gamma subfamily A, 2 2.35072
ZMYND10 zinc finger, MYND-type containing 10 2.35072
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 2.35072
GH1 growth hormone 1 2.35072
NPC1L1 NPC1-like 1 2.35072
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 2.35072
IRX1 iroquois homeobox 1 2.35072
MAGEC3 melanoma antigen family C3 2.35072
APOL3 apolipoprotein L, 3 2.35072
FAN1 FANCD2/FANCI-associated nuclease 1 2.35072
CD80 CD80 molecule 2.35072
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.35072
C5ORF46 chromosome 5 open reading frame 46 2.35072
ADRA1B adrenoceptor alpha 1B 2.35072
MYOZ2 myozenin 2 2.35072
TGM1 transglutaminase 1 2.35072
R3HDML R3H domain containing-like 2.35072
USP17L2 ubiquitin specific peptidase 17-like family member 2 2.35072
PLGLB2 plasminogen-like B2 2.35072
HRG histidine-rich glycoprotein 2.35072
HOXB3 homeobox B3 2.35072
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.35072
RBP3 retinol binding protein 3, interstitial 2.35072
GPA33 glycoprotein A33 (transmembrane) 2.35072
SPAG8 sperm associated antigen 8 2.35072
ZC2HC1B zinc finger, C2HC-type containing 1B 2.35072
ADGRF5 adhesion G protein-coupled receptor F5 2.35072
POU3F2 POU class 3 homeobox 2 2.35072
ZNF415 zinc finger protein 415 2.34592
WDR93 WD repeat domain 93 2.3092
TOE1 target of EGR1, member 1 (nuclear) 2.3092
CCDC192 coiled-coil domain containing 192 2.3092
FCRLB Fc receptor-like B 2.3092
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.3092
OVOL3 ovo-like zinc finger 3 2.3092
COMMD6 COMM domain containing 6 2.3092
MTX2 metaxin 2 2.3092
CRYZL2P-SEC16B CRYZL2P-SEC16B readthrough 2.3092
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2.3092
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.3092
LCN2 lipocalin 2 2.3092
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 2.3092
TPTE transmembrane phosphatase with tensin homology 2.3092
KIFC3 kinesin family member C3 2.29011
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.2856
DPY19L1 dpy-19-like 1 (C. elegans) 2.2856
CDKL3 cyclin-dependent kinase-like 3 2.27866
MRC2 mannose receptor, C type 2 2.27769
KRIT1 KRIT1, ankyrin repeat containing 2.26339
SEC61G Sec61 gamma subunit 2.26316
ACRV1 acrosomal vesicle protein 1 2.24038
FBXW12 F-box and WD repeat domain containing 12 2.23776
CDH8 cadherin 8, type 2 2.22898
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.22687
ZSWIM3 zinc finger, SWIM-type containing 3 2.18136
ZNF616 zinc finger protein 616 2.18092
CD46 CD46 molecule, complement regulatory protein 2.18048
STX1A syntaxin 1A (brain) 2.17335
PIKFYVE phosphoinositide kinase, FYVE finger containing 2.16758
NQO1 NAD(P)H dehydrogenase, quinone 1 2.16556
USP2 ubiquitin specific peptidase 2 2.15934
GUCA1B guanylate cyclase activator 1B (retina) 2.15634
ATRAID all-trans retinoic acid-induced differentiation factor 2.14269
PDCD11 programmed cell death 11 2.13655
TMX1 thioredoxin-related transmembrane protein 1 2.13655
FOXO3B forkhead box O3B pseudogene 2.12853
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 2.12853
THNSL1 threonine synthase-like 1 (S. cerevisiae) 2.11743
TSPAN11 tetraspanin 11 2.09574
RPL34 ribosomal protein L34 2.09492
USP6NL USP6 N-terminal like 2.09284
OXSR1 oxidative stress responsive 1 2.06994
RPL22 ribosomal protein L22 2.04777
TMEM91 transmembrane protein 91 2.04777
PCTP phosphatidylcholine transfer protein 2.0461
PARM1 prostate androgen-regulated mucin-like protein 1 2.03514
CCDC117 coiled-coil domain containing 117 2.02949
MT1X metallothionein 1X 2.02837
ZC3H13 zinc finger CCCH-type containing 13 2.02292
SLC25A40 solute carrier family 25, member 40 2.01823
NGFR nerve growth factor receptor 2.00832

decreased expression

Symbol Name Standardized Value
ALG11 ALG11, alpha-1,2-mannosyltransferase -2.35072
TRIM54 tripartite motif containing 54 -2.35072
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -2.35072
INHA inhibin, alpha -2.35072
CTNNBIP1 catenin, beta interacting protein 1 -2.35072
MSC musculin -2.35072
MFSD6L major facilitator superfamily domain containing 6-like -2.35072
S100A2 S100 calcium binding protein A2 -2.35072
MPV17 MpV17 mitochondrial inner membrane protein -2.35072
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.35072
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like -2.35072
UBE2S ubiquitin-conjugating enzyme E2S -2.35072
JMJD1C jumonji domain containing 1C -2.35072
C1ORF94 chromosome 1 open reading frame 94 -2.35072
BHLHE41 basic helix-loop-helix family, member e41 -2.35072
TIPRL TOR signaling pathway regulator -2.35072
BLTP3B bridge-like lipid transfer protein family member 3B -2.35072
BCL2L11 BCL2-like 11 (apoptosis facilitator) -2.35072
SCIN scinderin -2.35072
LHX1 LIM homeobox 1 -2.35072
WDR5 WD repeat domain 5 -2.32816
TPH1 tryptophan hydroxylase 1 -2.3092
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa -2.3092
CSNK2A3 casein kinase 2, alpha 3 polypeptide -2.3092
HASPIN histone H3 associated protein kinase -2.3092
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.3092
COPS4 COP9 signalosome subunit 4 -2.3092
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 -2.3092
PRSS22 protease, serine, 22 -2.3092
SPATS1 spermatogenesis associated, serine-rich 1 -2.3092
SLX9 SLX9 ribosome biogenesis factor -2.3092
SPMIP3 sperm microtubule inner protein 3 -2.3092
DUSP8 dual specificity phosphatase 8 -2.3092
C8ORF74 chromosome 8 open reading frame 74 -2.3092
IMPG1 interphotoreceptor matrix proteoglycan 1 -2.3092
COX8C cytochrome c oxidase subunit VIIIC -2.3092
ASB4 ankyrin repeat and SOCS box containing 4 -2.3092
OR1C1 olfactory receptor, family 1, subfamily C, member 1 -2.3092
GPR180 G protein-coupled receptor 180 -2.3092
CUL1 cullin 1 -2.3092
TRIM38 tripartite motif containing 38 -2.3092
ASB12 ankyrin repeat and SOCS box containing 12 -2.3092
OSTF1 osteoclast stimulating factor 1 -2.3092
CATSPERD catsper channel auxiliary subunit delta -2.3092
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.3092
TMPRSS2 transmembrane protease, serine 2 -2.3092
OR7D2 olfactory receptor, family 7, subfamily D, member 2 -2.3092
RBBP8NL RBBP8 N-terminal like -2.3092
EFCAB12 EF-hand calcium binding domain 12 -2.3092
SLC38A8 solute carrier family 38, member 8 -2.3092
TMEM150B transmembrane protein 150B -2.3092
CDH10 cadherin 10, type 2 (T2-cadherin) -2.3092
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -2.3092
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.3092
GOLGA8K golgin A8 family, member K -2.3092
MYF6 myogenic factor 6 (herculin) -2.3092
EPX eosinophil peroxidase -2.3092
ANGPTL6 angiopoietin-like 6 -2.3092
HPX hemopexin -2.3092
ADAM29 ADAM metallopeptidase domain 29 -2.3092
SDSL serine dehydratase-like -2.3092
BIN2 bridging integrator 2 -2.3092
S100Z S100 calcium binding protein Z -2.3092
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.2856
RMDN2 regulator of microtubule dynamics 2 -2.27866
MAT2A methionine adenosyltransferase II, alpha -2.27769
ZNF568 zinc finger protein 568 -2.26954
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 -2.26879
PCP4L1 Purkinje cell protein 4 like 1 -2.26509
RILPL2 Rab interacting lysosomal protein-like 2 -2.26039
SLC44A5 solute carrier family 44, member 5 -2.25575
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.25575
CALN1 calneuron 1 -2.2467
MAEA macrophage erythroblast attacher -2.23209
ZNF528 zinc finger protein 528 -2.23205
TTC26 tetratricopeptide repeat domain 26 -2.22898
ZNF835 zinc finger protein 835 -2.22151
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -2.22017
ARTN artemin -2.18136
RNMT RNA (guanine-7-) methyltransferase -2.18136
TIMM29 translocase of inner mitochondrial membrane 29 -2.17699
SYT16 synaptotagmin XVI -2.16758
EDRF1 erythroid differentiation regulatory factor 1 -2.15634
SERTAD1 SERTA domain containing 1 -2.15634
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -2.13899
FBL fibrillarin -2.13794
RETREG2 reticulophagy regulator family member 2 -2.12853
SPC24 SPC24, NDC80 kinetochore complex component -2.12752
FABP7 fatty acid binding protein 7, brain -2.12752
DRC9 dynein regulatory complex subunit 9 -2.09574
PGLYRP1 peptidoglycan recognition protein 1 -2.09284
CCND3 cyclin D3 -2.09284
PNPLA6 patatin-like phospholipase domain containing 6 -2.09164
G0S2 G0/G1 switch 2 -2.06054
RNF144B ring finger protein 144B -2.05046
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -2.04855
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -2.04777
LONRF2 LON peptidase N-terminal domain and ring finger 2 -2.03071
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.02632
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.02632
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 -2.02632
PDCD6IP programmed cell death 6 interacting protein -2.02632
C11ORF98 chromosome 11 open reading frame 98 -2.01823
JAG1 jagged 1 -2.01823
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase -2.01818
HDDC3 HD domain containing 3 -2.01818
FGFR3 fibroblast growth factor receptor 3 -2.01454
ANKRD31 ankyrin repeat domain 31 -2.01328
DNAH6 dynein, axonemal, heavy chain 6 -2.0132
DISC1 disrupted in schizophrenia 1 -2.00434