OGDH Gene Set

Dataset NURSA Protein-Protein Interactions
Category proteomics
Type interacting protein
Description oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)|This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 4967)
External Link http://www.ncbi.nlm.nih.gov/gene/4967
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Genes

10 interacting proteins for OGDH from the NURSA Protein-Protein Interactions dataset.

Symbol Name Standardized Value
DLD dihydrolipoamide dehydrogenase 2.29824
MRPS36 mitochondrial ribosomal protein S36 1.58888
OGDHL oxoglutarate dehydrogenase-like 1.51459
ACACA acetyl-CoA carboxylase alpha 1.26601
PDHB pyruvate dehydrogenase (lipoamide) beta 0.902704
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.902704
DLAT dihydrolipoamide S-acetyltransferase 0.538058
FAM161A family with sequence similarity 161, member A 0.527119
DBT dihydrolipoamide branched chain transacylase E2 0.069822
SIAH1 siah E3 ubiquitin protein ligase 1 0.022953