ORC1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description origin recognition complex, subunit 1|The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 4998)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_ORC1L
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Genes

69 co-expressed genes for ORC1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ANKRD12 ankyrin repeat domain 12
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARSE arylsulfatase E (chondrodysplasia punctata 1)
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP2 caspase 2, apoptosis-related cysteine peptidase
CELA2A chymotrypsin-like elastase family, member 2A
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNTN1 contactin 1
COPS2 COP9 signalosome subunit 2
CRYBA4 crystallin, beta A4
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DRG2 developmentally regulated GTP binding protein 2
FAM189B family with sequence similarity 189, member B
FCHO1 FCH domain only 1
GHITM growth hormone inducible transmembrane protein
GPR161 G protein-coupled receptor 161
GPR35 G protein-coupled receptor 35
GRK6 G protein-coupled receptor kinase 6
GSK3A glycogen synthase kinase 3 alpha
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
HMGB1 high mobility group box 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
IGHMBP2 immunoglobulin mu binding protein 2
IGSF9B immunoglobulin superfamily, member 9B
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRF2BP1 interferon regulatory factor 2 binding protein 1
KAT7 K(lysine) acetyltransferase 7
LSM12 LSM12 homolog (S. cerevisiae)
M6PR mannose-6-phosphate receptor (cation dependent)
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MVK mevalonate kinase
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
ORC1 origin recognition complex, subunit 1
PAIP2B poly(A) binding protein interacting protein 2B
PAX8 paired box 8
PCBP3 poly(rC) binding protein 3
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLIN3 perilipin 3
PNMT phenylethanolamine N-methyltransferase
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PRKCSH protein kinase C substrate 80K-H
PRPF8 pre-mRNA processing factor 8
PSD4 pleckstrin and Sec7 domain containing 4
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAP1GAP2 RAP1 GTPase activating protein 2
RFC1 replication factor C (activator 1) 1, 145kDa
RPA2 replication protein A2, 32kDa
SIK3 SIK family kinase 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SUMO4 small ubiquitin-like modifier 4
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAZ tafazzin
TCOF1 Treacher Collins-Franceschetti syndrome 1
TNK2 tyrosine kinase, non-receptor, 2
TOMM34 translocase of outer mitochondrial membrane 34
TSPO2 translocator protein 2
TUB tubby bipartite transcription factor
TXLNA taxilin alpha
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBED1 zinc finger, BED-type containing 1
ZFPL1 zinc finger protein-like 1
ZNF337 zinc finger protein 337