ORC1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description origin recognition complex, subunit 1|The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 4998)
External Link http://www.ncbi.nlm.nih.gov/gene/4998
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Genes

51 interacting proteins for ORC1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
CBX5 chromobox homolog 5
CCNA1 cyclin A1
CCNA2 cyclin A2
CDC45 cell division cycle 45
CDC5L cell division cycle 5-like
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDT1 chromatin licensing and DNA replication factor 1
DBF4 DBF4 zinc finger
FYN FYN proto-oncogene, Src family tyrosine kinase
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HMGA1 high mobility group AT-hook 1
HNF4A hepatocyte nuclear factor 4, alpha
JMY junction mediating and regulatory protein, p53 cofactor
KAT7 K(lysine) acetyltransferase 7
LRWD1 leucine-rich repeats and WD repeat domain containing 1
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MCM8 minichromosome maintenance complex component 8
MGMT O-6-methylguanine-DNA methyltransferase
ONECUT1 one cut homeobox 1
ORC2 origin recognition complex, subunit 2
ORC3 origin recognition complex, subunit 3
ORC4 origin recognition complex, subunit 4
ORC5 origin recognition complex, subunit 5
ORC6 origin recognition complex, subunit 6
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRIM2 primase, DNA, polypeptide 2 (58kDa)
RB1 retinoblastoma 1
RPA2 replication protein A2, 32kDa
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TERF2 telomeric repeat binding factor 2
TSG101 tumor susceptibility 101
UBB ubiquitin B
UBC ubiquitin C
XPO1 exportin 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)