ORC5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description origin recognition complex, subunit 5|The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010] (NCBI Entrez Gene Database, 5001)
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Genes

359 genes differentially expressed following the ORC5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KLHL30 kelch-like family member 30 2.92685
GLYAT glycine-N-acyltransferase 2.92685
HORMAD2 HORMA domain containing 2 2.92685
CCNB3 cyclin B3 2.92685
NOD2 nucleotide-binding oligomerization domain containing 2 2.92685
DRICH1 aspartate-rich 1 2.92685
VSTM2A V-set and transmembrane domain containing 2A 2.92685
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.92685
TAS2R1 taste receptor, type 2, member 1 2.92685
SHCBP1L SHC SH2-domain binding protein 1-like 2.92685
GPR22 G protein-coupled receptor 22 2.92685
ADAD2 adenosine deaminase domain containing 2 2.92685
FOXA2 forkhead box A2 2.92685
ADRB2 adrenoceptor beta 2, surface 2.92685
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.92685
PCDHA8 protocadherin alpha 8 2.92685
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.92685
FAM3D family with sequence similarity 3, member D 2.92685
SCARA5 scavenger receptor class A, member 5 2.92685
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.92685
MAP3K7CL MAP3K7 C-terminal like 2.92685
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.92685
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.92685
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.92685
PGAM2 phosphoglycerate mutase 2 (muscle) 2.92685
TAL2 T-cell acute lymphocytic leukemia 2 2.92685
C11ORF87 chromosome 11 open reading frame 87 2.92685
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.92685
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.92685
TMC8 transmembrane channel-like 8 2.92685
OVCH1 ovochymase 1 2.92685
SPX spexin hormone 2.92685
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.92685
PODNL1 podocan-like 1 2.92685
FAM110D family with sequence similarity 110, member D 2.92685
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.92685
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.92685
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.92685
TAS2R13 taste receptor, type 2, member 13 2.92685
HBZ hemoglobin, zeta 2.92685
FAM221B family with sequence similarity 221, member B 2.92685
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.92685
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.92685
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.92685
TDRD6 tudor domain containing 6 2.92685
NLRP10 NLR family, pyrin domain containing 10 2.92685
FSCN2 fascin actin-bundling protein 2, retinal 2.92685
EDDM3B epididymal protein 3B 2.92685
ARRDC2 arrestin domain containing 2 2.92685
KIF2B kinesin family member 2B 2.92685
MISP mitotic spindle positioning 2.92685
ZNF804B zinc finger protein 804B 2.92685
LOC114841035 uncharacterized LOC114841035 2.92685
CLDN14 claudin 14 2.92685
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.92685
DNAAF1 dynein, axonemal, assembly factor 1 2.92685
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.92685
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.92685
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.92685
ASB8 ankyrin repeat and SOCS box containing 8 2.92685
TMEM196 transmembrane protein 196 2.92685
FCMR Fc fragment of IgM receptor 2.92685
TSPAN1 tetraspanin 1 2.92685
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.92685
CLDN18 claudin 18 2.92685
RAG2 recombination activating gene 2 2.92685
LIPT2-AS1 LIPT2 antisense RNA 1 2.92685
PVALEF parvalbumin like EF-hand containing 2.92685
AKAIN1 A-kinase anchor inhibitor 1 2.92685
LY6L lymphocyte antigen 6 family member L 2.92685
CFAP206 cilia and flagella associated protein 206 2.92685
TMEM273 transmembrane protein 273 2.92685
GK3 glycerol kinase 3 2.92685
PLAAT4 phospholipase A and acyltransferase 4 2.92685
SMIM38 small integral membrane protein 38 2.92685
ASDURF ASNSD1 upstream open reading frame 2.92685
GBP6 guanylate binding protein family, member 6 2.92685
MRPS33 mitochondrial ribosomal protein S33 2.92685
LGSN lengsin, lens protein with glutamine synthetase domain 2.92685
CCDC92 coiled-coil domain containing 92 2.92685
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 2.92685
C1ORF162 chromosome 1 open reading frame 162 2.92685
MSX2 msh homeobox 2 2.92685
MSX1 msh homeobox 1 2.92685
TMEM235 transmembrane protein 235 2.92685
ULBP1 UL16 binding protein 1 2.92685
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.92685
WNT11 wingless-type MMTV integration site family, member 11 2.92685
FAM43B family with sequence similarity 43, member B 2.92685
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.92685
TPTE transmembrane phosphatase with tensin homology 2.92685
SLAMF7 SLAM family member 7 2.92685
FMR1NB fragile X mental retardation 1 neighbor 2.92685
ABHD15 abhydrolase domain containing 15 2.92685
BARX1 BARX homeobox 1 2.92685
GSC goosecoid homeobox 2.92685
PRR4 proline rich 4 (lacrimal) 2.92685
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.92685
KLRF2 killer cell lectin-like receptor subfamily F, member 2 2.92685
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.92685
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.92685
RUNX3 runt-related transcription factor 3 2.92685
ZAN zonadhesin (gene/pseudogene) 2.92685
GGT6 gamma-glutamyltransferase 6 2.92685
ZNF679 zinc finger protein 679 2.92685
GFY golgi-associated, olfactory signaling regulator 2.92685
MSMP microseminoprotein, prostate associated 2.92685
CLDN34 claudin 34 2.92685
SLC25A34 solute carrier family 25, member 34 2.92685
GPR12 G protein-coupled receptor 12 2.92685
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.92685
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.92685
CXCR6 chemokine (C-X-C motif) receptor 6 2.92685
OR10R2 olfactory receptor, family 10, subfamily R, member 2 2.92685
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.92685
TYR tyrosinase 2.92685
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.92685
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.92685
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 2.92685
CXCR4 chemokine (C-X-C motif) receptor 4 2.92685
C10ORF105 chromosome 10 open reading frame 105 2.92685
CCDC154 coiled-coil domain containing 154 2.92685
CCL27 chemokine (C-C motif) ligand 27 2.92685
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.92685
ERICH6 glutamate-rich 6 2.92685
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.92685
RGS8 regulator of G-protein signaling 8 2.92685
EXTL1 exostosin-like glycosyltransferase 1 2.92685
MCCD1 mitochondrial coiled-coil domain 1 2.92685
COX7B2 cytochrome c oxidase subunit VIIb2 2.92685
CLEC9A C-type lectin domain family 9, member A 2.92685
TEKT5 tektin 5 2.92685
LSMEM1 leucine-rich single-pass membrane protein 1 2.92685
LY96 lymphocyte antigen 96 2.92685
EGR2 early growth response 2 2.92685
ASTL astacin-like metallo-endopeptidase (M12 family) 2.92685
DRD2 dopamine receptor D2 2.92685
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.92685
KLF1 Kruppel-like factor 1 (erythroid) 2.92685
BCL2L15 BCL2-like 15 2.92685
OAZ3 ornithine decarboxylase antizyme 3 2.92685
CPA4 carboxypeptidase A4 2.92685
CLEC4C C-type lectin domain family 4, member C 2.92685
PGR progesterone receptor 2.92685
ADGRD1 adhesion G protein-coupled receptor D1 2.92685
MAB21L2 mab-21-like 2 (C. elegans) 2.92685
IRGM immunity-related GTPase family, M 2.92685
OCM oncomodulin 2.92685
PCDHGA11 protocadherin gamma subfamily A, 11 2.92685
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.92685
ADAM29 ADAM metallopeptidase domain 29 2.92685
TGM6 transglutaminase 6 2.92685
TMEM45B transmembrane protein 45B 2.92685
GJC2 gap junction protein, gamma 2, 47kDa 2.92685
IL10RA interleukin 10 receptor, alpha 2.92685
FOXP3 forkhead box P3 2.92685
LAMP3 lysosomal-associated membrane protein 3 2.92685
DNAH8 dynein, axonemal, heavy chain 8 2.92685
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.92685
SCIN scinderin 2.92685
NPR3 natriuretic peptide receptor 3 2.92685
FXYD2 FXYD domain containing ion transport regulator 2 2.92685
AMIGO3 adhesion molecule with Ig-like domain 3 2.92685
PSD2 pleckstrin and Sec7 domain containing 2 2.92685
ANKRD30A ankyrin repeat domain 30A 2.92685
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 2.92685
ASCL5 achaete-scute family bHLH transcription factor 5 2.92685
APOL4 apolipoprotein L, 4 2.92685
C22ORF31 chromosome 22 open reading frame 31 2.92685
MAPK11 mitogen-activated protein kinase 11 2.92685
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.92685
TEX29 testis expressed 29 2.92685
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.92685
ALOX15B arachidonate 15-lipoxygenase, type B 2.92685
TMEM255A transmembrane protein 255A 2.92685
ACKR2 atypical chemokine receptor 2 2.92685
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.92685
NUTM2D NUT family member 2D 2.92685
ACTB actin, beta 2.92685
STRC stereocilin 2.92685
ROM1 retinal outer segment membrane protein 1 2.92685
NAT10 N-acetyltransferase 10 (GCN5-related) 2.68202
BUB1B-PAK6 BUB1B-PAK6 readthrough 2.65687
ESRRB estrogen-related receptor beta 2.63332
UBC ubiquitin C 2.6254
BTN2A1 butyrophilin, subfamily 2, member A1 2.60768
OIP5 Opa interacting protein 5 2.59926
CFAP157 cilia and flagella associated protein 157 2.54769
C2 complement component 2 2.54769
LPXN leupaxin 2.47619
TESK1 testis-specific kinase 1 2.45981
TPM1 tropomyosin 1 (alpha) 2.45593
PHEX phosphate regulating endopeptidase homolog, X-linked 2.45453
XTBD1 XRN2 binding domain containing 1 2.45041
RNF227 ring finger protein 227 2.44275
ALX4 ALX homeobox 4 2.44275
TLR2 toll-like receptor 2 2.44275
TM7SF3 transmembrane 7 superfamily member 3 2.44275
RASA4 RAS p21 protein activator 4 2.44275
MROH9 maestro heat-like repeat family member 9 2.44005
TMEM245 transmembrane protein 245 2.42733
HAUS2 HAUS augmin-like complex, subunit 2 2.40416
PRSS23 protease, serine, 23 2.38905
ZXDC ZXD family zinc finger C 2.37377
PNPLA2 patatin-like phospholipase domain containing 2 2.34128
ANO4 anoctamin 4 2.33556
SCYL2 SCY1-like 2 (S. cerevisiae) 2.33368
RBM4 RNA binding motif protein 4 2.33318
FBXO46 F-box protein 46 2.30089
TIGD7 tigger transposable element derived 7 2.27725
HMGB3 high mobility group box 3 2.26411
MYSM1 Myb-like, SWIRM and MPN domains 1 2.22389
ANXA4 annexin A4 2.21502
HDAC9 histone deacetylase 9 2.21453
BLCAP bladder cancer associated protein 2.18976
CKS1B CDC28 protein kinase regulatory subunit 1B 2.17804
ERP29 endoplasmic reticulum protein 29 2.17614
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.1673
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 2.13698
MTFMT mitochondrial methionyl-tRNA formyltransferase 2.13675
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 2.13354
CSMD2 CUB and Sushi multiple domains 2 2.12519
PKN2 protein kinase N2 2.10804
SNX10 sorting nexin 10 2.09133
MATN2 matrilin 2 2.08652
USP20 ubiquitin specific peptidase 20 2.05126
LSAMP limbic system-associated membrane protein 2.02364
ZBTB20 zinc finger and BTB domain containing 20 2.02364
CHSY1 chondroitin sulfate synthase 1 2.01833
EDF1 endothelial differentiation-related factor 1 2.01303
SPAG17 sperm associated antigen 17 2.01171
TMEM60 transmembrane protein 60 2.00916
UGP2 UDP-glucose pyrophosphorylase 2 2.00916
ABHD4 abhydrolase domain containing 4 2.00237

decreased expression

Symbol Name Standardized Value
PARP3 poly (ADP-ribose) polymerase family, member 3 -2.92685
SOST sclerostin -2.92685
GRM6 glutamate receptor, metabotropic 6 -2.92685
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.92685
PLXND1 plexin D1 -2.92685
ORC5 origin recognition complex, subunit 5 -2.92685
CPZ carboxypeptidase Z -2.92685
MPZL2 myelin protein zero-like 2 -2.92685
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -2.92685
ARHGAP20 Rho GTPase activating protein 20 -2.92685
IMPG2 interphotoreceptor matrix proteoglycan 2 -2.92685
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 -2.92685
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -2.92685
IDUA iduronidase, alpha-L- -2.92685
IZUMO3 IZUMO family member 3 -2.92685
PLXDC1 plexin domain containing 1 -2.92685
MED7 mediator complex subunit 7 -2.92685
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -2.92685
CA1 carbonic anhydrase I -2.92685
SFTPB surfactant protein B -2.92685
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -2.92685
CES3 carboxylesterase 3 -2.92685
SAP30L SAP30-like -2.92685
TAS2R30 taste receptor, type 2, member 30 -2.92685
AMIGO1 adhesion molecule with Ig-like domain 1 -2.92685
HPD 4-hydroxyphenylpyruvate dioxygenase -2.92685
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase -2.92685
PCDHAC1 protocadherin alpha subfamily C, 1 -2.92685
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.92685
RIN1 Ras and Rab interactor 1 -2.92685
KDM2A lysine (K)-specific demethylase 2A -2.92685
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -2.92685
CCDC194 coiled-coil domain containing 194 -2.92685
LOC124904542 uncharacterized LOC124904542 -2.92685
NPIPB12 nuclear pore complex interacting protein family member B12 -2.92685
CTSF cathepsin F -2.92685
SLC45A1 solute carrier family 45, member 1 -2.92685
DNAAF19 dynein axonemal assembly factor 19 -2.92685
CFAP73 cilia and flagella associated protein 73 -2.92685
LCT lactase -2.92685
STYXL2 serine/threonine/tyrosine interacting like 2 -2.92685
GRAMD2A GRAM domain containing 2A -2.92685
MIEN1 migration and invasion enhancer 1 -2.92685
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.92685
PXMP4 peroxisomal membrane protein 4, 24kDa -2.92525
NPC1 Niemann-Pick disease, type C1 -2.89506
H2BC14 H2B clustered histone 14 -2.87449
SH3GL2 SH3-domain GRB2-like 2 -2.81451
ASIP agouti signaling protein -2.80234
INKA1 inka box actin regulator 1 -2.76736
C17ORF78 chromosome 17 open reading frame 78 -2.76736
LRP12 low density lipoprotein receptor-related protein 12 -2.68795
SMIM24 small integral membrane protein 24 -2.68196
GJA5 gap junction protein, alpha 5, 40kDa -2.68196
ZNF230 zinc finger protein 230 -2.68196
TBC1D31 TBC1 domain family, member 31 -2.6696
JRKL JRK-like -2.64057
RAB25 RAB25, member RAS oncogene family -2.61411
ZNF772 zinc finger protein 772 -2.52802
PTK7 protein tyrosine kinase 7 (inactive) -2.51534
CALCR calcitonin receptor -2.49812
C1QTNF2 C1q and tumor necrosis factor related protein 2 -2.46867
OAF OAF homolog (Drosophila) -2.46867
FLYWCH2 FLYWCH family member 2 -2.45593
SLC25A53 solute carrier family 25, member 53 -2.4383
TMEM70 transmembrane protein 70 -2.4383
CHD4 chromodomain helicase DNA binding protein 4 -2.42358
SNX7 sorting nexin 7 -2.40318
KIRREL2 kin of IRRE like 2 (Drosophila) -2.35268
RGPD1 RANBP2-like and GRIP domain containing 1 -2.35268
ECT2L epithelial cell transforming 2 like -2.35268
NTNG2 netrin G2 -2.35268
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa -2.34216
ZC3H12B zinc finger CCCH-type containing 12B -2.33531
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit -2.30333
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 -2.30306
ZNF17 zinc finger protein 17 -2.30306
FIG4 FIG4 phosphoinositide 5-phosphatase -2.30156
HDAC2 histone deacetylase 2 -2.30156
GOSR1 golgi SNAP receptor complex member 1 -2.29976
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -2.29799
TPP1 tripeptidyl peptidase I -2.29656
SAXO6 stabilizer of axonemal microtubules 6 -2.29192
RAB6B RAB6B, member RAS oncogene family -2.24322
TTC4 tetratricopeptide repeat domain 4 -2.23867
YIPF4 Yip1 domain family, member 4 -2.23867
MRPL11 mitochondrial ribosomal protein L11 -2.23867
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -2.23669
AK2 adenylate kinase 2 -2.23669
ZNF829 zinc finger protein 829 -2.23669
ADAT2 adenosine deaminase, tRNA-specific 2 -2.23669
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -2.23137
RBMS1 RNA binding motif, single stranded interacting protein 1 -2.22767
SYT2 synaptotagmin II -2.22667
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.22568
TTC13 tetratricopeptide repeat domain 13 -2.21502
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.21502
AEBP1 AE binding protein 1 -2.21502
BRD9 bromodomain containing 9 -2.18976
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -2.18976
NAP1L5 nucleosome assembly protein 1-like 5 -2.18304
MRTFB myocardin related transcription factor B -2.17804
HDAC3 histone deacetylase 3 -2.17614
SLC35B1 solute carrier family 35, member B1 -2.17238
SHROOM3 shroom family member 3 -2.17167
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.1571
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.12744
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta -2.11389
UPK3BL1 uroplakin 3B like 1 -2.11389
POR P450 (cytochrome) oxidoreductase -2.10953
VANGL2 VANGL planar cell polarity protein 2 -2.09801
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 -2.09801
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -2.08652
CXXC1 CXXC finger protein 1 -2.08524
HOOK3 hook microtubule-tethering protein 3 -2.07295
ABHD14B abhydrolase domain containing 14B -2.06592
THSD7A thrombospondin, type I, domain containing 7A -2.0405
GLDN gliomedin -2.0405
MYRIP myosin VIIA and Rab interacting protein -2.03996
KRT8 keratin 8, type II -2.02677
SCML1 sex comb on midleg-like 1 (Drosophila) -2.02334
IGSF21 immunoglobin superfamily, member 21 -2.01833
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.01171
GRK2 G protein-coupled receptor kinase 2 -2.01129
LINC02610 long intergenic non-protein coding RNA 2610 -2.00237